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Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc

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The coagulation protease activated protein C (aPC) confers cytoprotective effects in various in vitro and in vivo disease models, including diabetic nephropathy. The nephroprotective effect may be related to antioxidant effects of aPC. However, the mechanism through which aPC may convey these antiox...

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Main Authors: Bock, Fabian (Author) , Shahzad Hussain, Khurrum (Author) , Wang, Hongjie (Author) , Stoyanov, Stoyan Borislavov (Author) , Wolter, Juliane (Author) , Dong, Wei (Author) , Pelicci, Pier Giuseppe (Author) , Kashif, Muhammed (Author) , Ranjan, Satish (Author) , Schmidt, Simone (Author) , Ritzel, Robert (Author) , Schwenger, Vedat (Author) , Reymann, Klaus G. (Author) , Esmon, Charles T. (Author) , Madhusudhan, Thati (Author) , Nawroth, Peter Paul (Author) , Isermann, Berend (Author)
Format: Article (Journal)
Language:English
Published: January 8, 2013
In: Proceedings of the National Academy of Sciences of the United States of America
Year: 2013, Volume: 110, Issue: 2, Pages: 648-653
ISSN:1091-6490
DOI:10.1073/pnas.1218667110
Online Access:Verlag, Volltext: https://doi.org/10.1073/pnas.1218667110
Verlag, Volltext: https://www.pnas.org/content/110/2/648
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Author Notes:Fabian Bock, Khurrum Shahzad, Hongjie Wang, Stoyan Stoyanov, Juliane Wolter, Wei Dong, Pier Giuseppe Pelicci, Muhammed Kashif, Satish Ranjan, Simone Schmidt, Robert Ritzel, Vedat Schwenger, Klaus G. Reymann, Charles T. Esmon, Thati Madhusudhan, Peter P. Nawroth, and Berend Isermann
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Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc by Bock, Fabian (Author) , Shahzad Hussain, Khurrum (Author) , Wang, Hongjie (Author) , Stoyanov, Stoyan Borislavov (Author) , Wolter, Juliane (Author) , Dong, Wei (Author) , Pelicci, Pier Giuseppe (Author) , Kashif, Muhammed (Author) , Ranjan, Satish (Author) , Schmidt, Simone (Author) , Ritzel, Robert (Author) , Schwenger, Vedat (Author) , Reymann, Klaus G. (Author) , Esmon, Charles T. (Author) , Madhusudhan, Thati (Author) , Nawroth, Peter Paul (Author) , Isermann, Berend (Author) ,


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