Oncogene-induced senescence: a potential breakpoint mechanism against malignant transformation in plasma cell disorders
Oncogene-induced senescence (OIS) is a cellular tumor-suppressive mechanism present in several premalignant conditions. Here, we analyze the possible impact of OIS on malignant transformation in plasma cell disorders. Tumor samples from 125 patients with different disease stages were analyzed immuno...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
04 Apr 2018
|
| In: |
Leukemia and lymphoma
Year: 2018, Jahrgang: 59, Heft: 11, Pages: 2660-2669 |
| ISSN: | 1029-2403 |
| DOI: | 10.1080/10428194.2018.1443450 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1080/10428194.2018.1443450
|
| Verfasserangaben: | Nicola Lehners, Elena Ellert, Jing Xu, Jens Hillengass, Jonas Leichsenring, Albrecht Stenzinger, Hartmut Goldschmidt, Mindaugas Andrulis, Marc S. Raab |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1691027677 | ||
| 003 | DE-627 | ||
| 005 | 20220818000954.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200226s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/10428194.2018.1443450 |2 doi | |
| 035 | |a (DE-627)1691027677 | ||
| 035 | |a (DE-599)KXP1691027677 | ||
| 035 | |a (OCoLC)1341308088 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Giesen, Nicola |d 1983- |e VerfasserIn |0 (DE-588)141844272 |0 (DE-627)631828524 |0 (DE-576)32643657X |4 aut | |
| 245 | 1 | 0 | |a Oncogene-induced senescence |b a potential breakpoint mechanism against malignant transformation in plasma cell disorders |c Nicola Lehners, Elena Ellert, Jing Xu, Jens Hillengass, Jonas Leichsenring, Albrecht Stenzinger, Hartmut Goldschmidt, Mindaugas Andrulis, Marc S. Raab |
| 264 | 1 | |c 04 Apr 2018 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.02.2020 | ||
| 520 | |a Oncogene-induced senescence (OIS) is a cellular tumor-suppressive mechanism present in several premalignant conditions. Here, we analyze the possible impact of OIS on malignant transformation in plasma cell disorders. Tumor samples from 125 patients with different disease stages were analyzed immunohistochemically for expression of senescence markers. Protein expression of cyclin-dependent kinase inhibitor p21Cip1/Waf1 was significantly higher in smoldering multiple myeloma (SMM) compared to monoclonal gammopathy of undetermined significance (MGUS) (p = .02) or symptomatic multiple myeloma (MM) (p = .005). SMM plasma cells expressing p21Cip1/Waf1 were negative for Ki67, consistent with senescence. While p27Kip1 was highly expressed in healthy controls, MGUS and SMM, expression decreased significantly in MM (p = .02). SMM plasma cells displayed a mutually exclusive expression of p21Cip1/Waf1/p27Kip1 suggesting compensatory mechanisms of senescence. In conclusion, we found markers of cellular senescence differentially expressed in SMM compared to MGUS and MM supporting the hypothesis of OIS as a breakpoint mechanism against malignant transformation in plasma cell disorders. | ||
| 650 | 4 | |a Hematological malignancy | |
| 650 | 4 | |a MGUS | |
| 650 | 4 | |a multiple myeloma | |
| 650 | 4 | |a senescence | |
| 650 | 4 | |a tumor suppression | |
| 700 | 1 | |a Ellert, Elena |d 1985- |e VerfasserIn |0 (DE-588)1073653927 |0 (DE-627)829304797 |0 (DE-576)435232428 |4 aut | |
| 700 | 1 | |a Xu, Jing |e VerfasserIn |0 (DE-588)1155026799 |0 (DE-627)1016328982 |0 (DE-576)501390545 |4 aut | |
| 700 | 1 | |a Hillengaß, Jens |d 1974- |e VerfasserIn |0 (DE-588)124918549 |0 (DE-627)368073823 |0 (DE-576)294568298 |4 aut | |
| 700 | 1 | |a Leichsenring, Jonas |d 1985- |e VerfasserIn |0 (DE-588)112053464X |0 (DE-627)873481879 |0 (DE-576)480419272 |4 aut | |
| 700 | 1 | |a Stenzinger, Albrecht |e VerfasserIn |0 (DE-588)139606106 |0 (DE-627)703395238 |0 (DE-576)312432755 |4 aut | |
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 700 | 1 | |a Andrulis, Mindaugas |d 1972- |e VerfasserIn |0 (DE-588)131682172 |0 (DE-627)512716587 |0 (DE-576)298670534 |4 aut | |
| 700 | 1 | |a Raab, Marc-Steffen |d 1973- |e VerfasserIn |0 (DE-588)124052460 |0 (DE-627)706520998 |0 (DE-576)293998027 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Leukemia and lymphoma |d London [u.a.] : Taylor & Francis Group, 1989 |g 59(2018), 11, Seite 2660-2669 |h Online-Ressource |w (DE-627)324746237 |w (DE-600)2030637-4 |w (DE-576)099718170 |x 1029-2403 |7 nnas |a Oncogene-induced senescence a potential breakpoint mechanism against malignant transformation in plasma cell disorders |
| 773 | 1 | 8 | |g volume:59 |g year:2018 |g number:11 |g pages:2660-2669 |g extent:10 |a Oncogene-induced senescence a potential breakpoint mechanism against malignant transformation in plasma cell disorders |
| 856 | 4 | 0 | |u https://doi.org/10.1080/10428194.2018.1443450 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200226 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 124052460 |a Raab, Marc-Steffen |m 124052460:Raab, Marc-Steffen |d 910000 |d 910100 |e 910000PR124052460 |e 910100PR124052460 |k 0/910000/ |k 1/910000/910100/ |p 9 |y j | ||
| 998 | |g 131682172 |a Andrulis, Mindaugas |m 131682172:Andrulis, Mindaugas |p 8 | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |d 910100 |e 910000PG102258023X |e 910100PG102258023X |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 139606106 |a Stenzinger, Albrecht |m 139606106:Stenzinger, Albrecht |d 910000 |d 912000 |e 910000PS139606106 |e 912000PS139606106 |k 0/910000/ |k 1/910000/912000/ |p 6 | ||
| 998 | |g 112053464X |a Leichsenring, Jonas |m 112053464X:Leichsenring, Jonas |d 910000 |d 912000 |e 910000PL112053464X |e 912000PL112053464X |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 998 | |g 124918549 |a Hillengaß, Jens |m 124918549:Hillengaß, Jens |d 910000 |d 910100 |e 910000PH124918549 |e 910100PH124918549 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1155026799 |a Xu, Jing |m 1155026799:Xu, Jing |d 910000 |d 910100 |e 910000PX1155026799 |e 910100PX1155026799 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1073653927 |a Ellert, Elena |m 1073653927:Ellert, Elena |p 2 | ||
| 998 | |g 141844272 |a Giesen, Nicola |m 141844272:Giesen, Nicola |d 910000 |d 910100 |e 910000PG141844272 |e 910100PG141844272 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1691027677 |e 3598460171 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"subtitle":"a potential breakpoint mechanism against malignant transformation in plasma cell disorders","title_sort":"Oncogene-induced senescence","title":"Oncogene-induced senescence"}],"person":[{"role":"aut","display":"Giesen, Nicola","family":"Giesen","given":"Nicola"},{"display":"Ellert, Elena","family":"Ellert","given":"Elena","role":"aut"},{"display":"Xu, Jing","given":"Jing","family":"Xu","role":"aut"},{"family":"Hillengaß","given":"Jens","display":"Hillengaß, Jens","role":"aut"},{"role":"aut","family":"Leichsenring","given":"Jonas","display":"Leichsenring, Jonas"},{"role":"aut","family":"Stenzinger","given":"Albrecht","display":"Stenzinger, Albrecht"},{"display":"Goldschmidt, Hartmut","family":"Goldschmidt","given":"Hartmut","role":"aut"},{"role":"aut","family":"Andrulis","given":"Mindaugas","display":"Andrulis, Mindaugas"},{"role":"aut","given":"Marc-Steffen","family":"Raab","display":"Raab, Marc-Steffen"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"04 Apr 2018","dateIssuedKey":"2018"}],"note":["Gesehen am 26.02.2020"],"id":{"eki":["1691027677"],"doi":["10.1080/10428194.2018.1443450"]},"recId":"1691027677","relHost":[{"note":["Gesehen am 08.09.15"],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisher":"Taylor & Francis Group ; Informa Healthcare","dateIssuedDisp":"1989-","publisherPlace":"London [u.a.] ; London [u.a.]","dateIssuedKey":"1989"}],"title":[{"title_sort":"Leukemia and lymphoma","title":"Leukemia and lymphoma"}],"pubHistory":["1.1989/90 -"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Oncogene-induced senescence a potential breakpoint mechanism against malignant transformation in plasma cell disordersLeukemia and lymphoma","part":{"year":"2018","issue":"11","text":"59(2018), 11, Seite 2660-2669","volume":"59","pages":"2660-2669","extent":"10"},"recId":"324746237","id":{"eki":["324746237"],"issn":["1029-2403"],"zdb":["2030637-4"]}}],"name":{"displayForm":["Nicola Lehners, Elena Ellert, Jing Xu, Jens Hillengass, Jonas Leichsenring, Albrecht Stenzinger, Hartmut Goldschmidt, Mindaugas Andrulis, Marc S. Raab"]},"physDesc":[{"extent":"10 S."}],"language":["eng"]} | ||
| SRT | |a GIESENNICOONCOGENEIN0420 | ||