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Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

There are several classes of sensory neuron that contribute to pain states. Here, the authors demonstrate that TrkB+ sensory neurons detect light touch under normal conditions in mice but contribute to hypersensitivity in models of chronic pain, and that ligand-guided laser ablation of TrkB+ sensory...

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Main Authors: Dhandapani, Rahul (Author) , Arokiaraj, Cynthia Mary (Author) , Taberner, Francisco J. (Author) , Hussain, Ahmad Fawzi (Author) , Barth, Stefan (Author) , Johnsson, Kai (Author) , Lechner, Stefan (Author) , Heppenstall, Paul A. (Author)
Format: Article (Journal)
Language:English
Published: 24 April 2018
In: Nature Communications
Year: 2018, Volume: 9
ISSN:2041-1723
DOI:10.1038/s41467-018-04049-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-018-04049-3
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-018-04049-3
Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915601
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Author Notes:Rahul Dhandapani, Cynthia Mary Arokiaraj, Francisco J. Taberner, Paola Pacifico, Sruthi Raja, Linda Nocchi, Carla Portulano, Federica Franciosa, Mariano Maffei, Ahmad Fawzi Hussain, Fernanda de Castro Reis, Luc Reymond, Emerald Perlas, Simone Garcovich, Stefan Barth, Kai Johnsson, Stefan G. Lechner, Paul A. Heppenstall
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Summary:There are several classes of sensory neuron that contribute to pain states. Here, the authors demonstrate that TrkB+ sensory neurons detect light touch under normal conditions in mice but contribute to hypersensitivity in models of chronic pain, and that ligand-guided laser ablation of TrkB+ sensory neurons in the mouse skin attenuates this hypersensitivity.
Item Description:Gesehen am 27.02.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-018-04049-3

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