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Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke

Background and aims - Matrix metalloproteinase (MMP)-8 and myeloperoxidase (MPO) may contribute to cerebral damage in acute ischemic stroke. We tested the hypothesis that levels of MPO, MMP-8 and the ratio between MMP-8 and its regulator, tissue inhibitor of metalloproteinase (TIMP-1), are increased...

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Main Authors: Palm, Frederick (Author) , Pussinen, Pirkko J. (Author) , Safer, Anton (Author) , Tervahartiala, Taina (Author) , Sorsa, Timo (Author) , Urbanek, Christian (Author) , Becher, Heiko (Author) , Grau, Armin J. (Author)
Format: Article (Journal)
Language:English
Published: 8 February 2018
In: Atherosclerosis
Year: 2018, Volume: 271, Pages: 9-14
ISSN:1879-1484
DOI:10.1016/j.atherosclerosis.2018.02.012
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.atherosclerosis.2018.02.012
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0021915018300753
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Author Notes:Frederick Palm, Pirkko J. Pussinen, Anton Safer, Taina Tervahartiala, Timo Sorsa, Christian Urbanek, Heiko Becher, Armin J. Grau

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520 |a Background and aims - Matrix metalloproteinase (MMP)-8 and myeloperoxidase (MPO) may contribute to cerebral damage in acute ischemic stroke. We tested the hypothesis that levels of MPO, MMP-8 and the ratio between MMP-8 and its regulator, tissue inhibitor of metalloproteinase (TIMP-1), are increased in acute ischemic stroke and its etiologic subgroups and they correlate with stroke severity. - Methods - In a cross-sectional case-control study, serum concentrations of MMP-8, MPO and TIMP-1 were assessed within 24h after admission in 470 first-ever ischemic stroke patients and 809 age- and sex-matched controls, randomly selected from the population. Odds ratios (OR) per decade of log transformed dependent variables were calculated and adjusted for age, sex and vascular risk factors. - Results - Levels of MMP-8 (OR 4.9; 95% CI 3.4-7.2), MMP-8/TIMP-1 ratio (3.0; 2.2-4.1) and MPO (6.6; 4.0-11.0) were independently associated with ischemic stroke. MMP-8 levels differed between etiologic stroke subgroups (p=0.019, ANOVA), with higher levels in cardioembolic stroke and stroke due to large vessel disease, and lower levels in microangiopathic stroke. MMP-8, MMP-8/TIMP-1 ratio and MPO (p < 0.001) concentrations showed positive associations with stroke severity independent of stroke etiology. - Conclusions - Concentrations of serum neutrophil markers are increased after ischemic stroke and associate with stroke severity and etiology. The value of these biomarkers in diagnostics and prognostics is worth being evaluated. 
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