Prognostic factors and long-term survival in surgically treated brain metastases from non-small cell lung cancer
Objective - Brain metastases (BMs) are the most common malignant brain tumors in adults. Despite multimodal treatment options such as microsurgery, radiotherapy and chemotherapy, prognosis still remains very poor. Non-small cell lung cancer (NSCLC) constitutes the most common source of brain metasta...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 January 2016
|
| In: |
Clinical neurology and neurosurgery
Year: 2016, Jahrgang: 142, Pages: 72-80 |
| ISSN: | 1872-6968 |
| DOI: | 10.1016/j.clineuro.2016.01.011 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.clineuro.2016.01.011 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0303846716300117 
|
| Verfasserangaben: | Frederik Enders, Christoph Geisenberger, Christine Jungk, Justo Lorenzo Bermejo, Rolf Warta, Andreas von Deimling, Christel Herold-Mende, Andreas Unterberg |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1691264091 | ||
| 003 | DE-627 | ||
| 005 | 20230428055033.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200228s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.clineuro.2016.01.011 |2 doi | |
| 035 | |a (DE-627)1691264091 | ||
| 035 | |a (DE-599)KXP1691264091 | ||
| 035 | |a (OCoLC)1341308678 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Enders, Frederik |d 1983- |e VerfasserIn |0 (DE-588)106494972X |0 (DE-627)815336071 |0 (DE-576)424553341 |4 aut | |
| 245 | 1 | 0 | |a Prognostic factors and long-term survival in surgically treated brain metastases from non-small cell lung cancer |c Frederik Enders, Christoph Geisenberger, Christine Jungk, Justo Lorenzo Bermejo, Rolf Warta, Andreas von Deimling, Christel Herold-Mende, Andreas Unterberg |
| 264 | 1 | |c 14 January 2016 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.02.2020 | ||
| 520 | |a Objective - Brain metastases (BMs) are the most common malignant brain tumors in adults. Despite multimodal treatment options such as microsurgery, radiotherapy and chemotherapy, prognosis still remains very poor. Non-small cell lung cancer (NSCLC) constitutes the most common source of brain metastases. In this study, prognostic factors in this patient population were identified through an in-depth analysis of clinical parameters of patients with BMs from NSCLC. - Patients and methods - Clinical data of 114 NSCLC cancer patients who underwent surgery for BMs at the University Hospital Heidelberg were retrospectively reviewed for age, gender, type of treatment, time course of the disease, presence of neurologic symptoms, Karnofsky Performance Status (KPS), smoking history, presence of extracranial metastases at initial diagnosis of NSCLC, number, location and size of brain metastases. Univariate and multivariate survival analyses were performed using the Log-rank test and Cox’ proportional hazard model, respectively. - Results - Median survival time from surgery for BMs was 11.2 months. 18.4% (21 of 114) patients were long-term survivors (>24 months; range 26.3-75.1 months). Age, gender, size and number of intracranial metastases were not significantly associated with patient survival. Univariate analysis identified complete resection, postoperative whole brain radiotherapy (WBRT) and a preoperative KPS of >80% as positive prognostic factors. Infratentorial location and presence of extracranial metastases were shown to be negative prognostic factors. Surgery for the primary tumor was associated with a superior patient outcome both in univariate and multivariate analyses. - Conclusion - Our data strongly suggest that surgical treatment of the primary tumor and complete resection of brain metastases in NSCLC patients followed by WBRT improve survival. Moreover, long-term survivors (>2 years) were more frequent than previously reported. | ||
| 650 | 4 | |a Brain metastases | |
| 650 | 4 | |a Long-term survivors | |
| 650 | 4 | |a NSCLC | |
| 650 | 4 | |a Prognostic factors | |
| 650 | 4 | |a Treatment | |
| 700 | 1 | |a Geisenberger, Christoph |d 1987- |e VerfasserIn |0 (DE-588)1071914707 |0 (DE-627)826603319 |0 (DE-576)433424842 |4 aut | |
| 700 | 1 | |a Jungk, Christine |e VerfasserIn |0 (DE-588)1051888247 |0 (DE-627)78696765X |0 (DE-576)407515968 |4 aut | |
| 700 | 1 | |a Lorenzo Bermejo, Justo |d 1972- |e VerfasserIn |0 (DE-588)124754619 |0 (DE-627)706705572 |0 (DE-576)294483632 |4 aut | |
| 700 | 1 | |a Warta, Rolf |d 1980- |e VerfasserIn |0 (DE-588)1047472260 |0 (DE-627)778430839 |0 (DE-576)401088030 |4 aut | |
| 700 | 1 | |a Deimling, Andreas von |d 1959- |e VerfasserIn |0 (DE-588)103034115X |0 (DE-627)735093946 |0 (DE-576)378138065 |4 aut | |
| 700 | 1 | |a Herold-Mende, Christel |e VerfasserIn |0 (DE-588)1022936549 |0 (DE-627)717335577 |0 (DE-576)366194267 |4 aut | |
| 700 | 1 | |a Unterberg, Andreas |e VerfasserIn |0 (DE-588)1032681187 |0 (DE-627)738641200 |0 (DE-576)168441233 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical neurology and neurosurgery |d Amsterdam [u.a.] : Elsevier Science, 1974 |g 142(2016), Seite 72-80 |h Online-Ressource |w (DE-627)320438236 |w (DE-600)2004613-3 |w (DE-576)261862197 |x 1872-6968 |7 nnas |a Prognostic factors and long-term survival in surgically treated brain metastases from non-small cell lung cancer |
| 773 | 1 | 8 | |g volume:142 |g year:2016 |g pages:72-80 |g extent:9 |a Prognostic factors and long-term survival in surgically treated brain metastases from non-small cell lung cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.clineuro.2016.01.011 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0303846716300117 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200228 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1032681187 |a Unterberg, Andreas |m 1032681187:Unterberg, Andreas |d 910000 |d 911200 |e 910000PU1032681187 |e 911200PU1032681187 |k 0/910000/ |k 1/910000/911200/ | ||
| 998 | |g 1022936549 |a Herold-Mende, Christel |m 1022936549:Herold-Mende, Christel |d 910000 |d 911200 |e 910000PH1022936549 |e 911200PH1022936549 |k 0/910000/ |k 1/910000/911200/ | ||
| 998 | |g 103034115X |a Deimling, Andreas von |m 103034115X:Deimling, Andreas von |d 910000 |d 912000 |e 910000PD103034115X |e 912000PD103034115X |k 0/910000/ |k 1/910000/912000/ | ||
| 998 | |g 1047472260 |a Warta, Rolf |m 1047472260:Warta, Rolf |d 910000 |d 911200 |e 910000PW1047472260 |e 911200PW1047472260 |k 0/910000/ |k 1/910000/911200/ | ||
| 998 | |g 124754619 |a Lorenzo Bermejo, Justo |m 124754619:Lorenzo Bermejo, Justo |d 910000 |d 999701 |e 910000PL124754619 |e 999701PL124754619 |k 0/910000/ |k 1/910000/999701/ | ||
| 998 | |g 1051888247 |a Jungk, Christine |m 1051888247:Jungk, Christine |d 910000 |d 911200 |e 910000PJ1051888247 |e 911200PJ1051888247 |k 0/910000/ |k 1/910000/911200/ | ||
| 998 | |g 1071914707 |a Geisenberger, Christoph |m 1071914707:Geisenberger, Christoph |d 910000 |d 911200 |e 910000PG1071914707 |e 911200PG1071914707 |k 0/910000/ |k 1/910000/911200/ | ||
| 998 | |g 106494972X |a Enders, Frederik |m 106494972X:Enders, Frederik |d 910000 |d 911200 |e 910000PE106494972X |e 911200PE106494972X |k 0/910000/ |k 1/910000/911200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1691264091 |e 3599248052 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1691264091"],"doi":["10.1016/j.clineuro.2016.01.011"]},"person":[{"display":"Enders, Frederik","given":"Frederik","family":"Enders","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Geisenberger, Christoph","given":"Christoph","family":"Geisenberger","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Jungk, Christine","roleDisplay":"VerfasserIn","role":"aut","given":"Christine","family":"Jungk"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Justo","family":"Lorenzo Bermejo","display":"Lorenzo Bermejo, Justo"},{"display":"Warta, Rolf","family":"Warta","given":"Rolf","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Andreas von","family":"Deimling","roleDisplay":"VerfasserIn","role":"aut","display":"Deimling, Andreas von"},{"family":"Herold-Mende","given":"Christel","role":"aut","roleDisplay":"VerfasserIn","display":"Herold-Mende, Christel"},{"display":"Unterberg, Andreas","roleDisplay":"VerfasserIn","role":"aut","family":"Unterberg","given":"Andreas"}],"relHost":[{"id":{"issn":["1872-6968"],"eki":["320438236"],"zdb":["2004613-3"]},"recId":"320438236","language":["eng"],"title":[{"subtitle":"official publication of the Netherlands Society of Neurology and the Netherlands Society of Neurosurgery and the Flemish Society of Neurology","title_sort":"Clinical neurology and neurosurgery","title":"Clinical neurology and neurosurgery"}],"pubHistory":["Nachgewiesen 77.1974 -"],"note":["Gesehen am 04.02.20"],"origin":[{"publisher":"Elsevier Science","dateIssuedKey":"1974","dateIssuedDisp":"1974-","publisherPlace":"Amsterdam [u.a.]"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"year":"2016","text":"142(2016), Seite 72-80","volume":"142","extent":"9","pages":"72-80"},"physDesc":[{"extent":"Online-Ressource"}],"disp":"Prognostic factors and long-term survival in surgically treated brain metastases from non-small cell lung cancerClinical neurology and neurosurgery"}],"physDesc":[{"extent":"9 S."}],"name":{"displayForm":["Frederik Enders, Christoph Geisenberger, Christine Jungk, Justo Lorenzo Bermejo, Rolf Warta, Andreas von Deimling, Christel Herold-Mende, Andreas Unterberg"]},"language":["eng"],"recId":"1691264091","title":[{"title_sort":"Prognostic factors and long-term survival in surgically treated brain metastases from non-small cell lung cancer","title":"Prognostic factors and long-term survival in surgically treated brain metastases from non-small cell lung cancer"}],"note":["Gesehen am 28.02.2020"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"14 January 2016"}]} | ||
| SRT | |a ENDERSFREDPROGNOSTIC1420 | ||