Inhibition of multidrug resistance-associated protein 2 (MRP2) activity by the contraceptive nomegestrol acetate in HepG2 and Caco-2 cells
Multidrug resistance-associated protein 2 (MRP2) plays a key role in hepatic and intestinal disposition of endo- and xenobiotics. Several therapeutic agents modulate MRP2 activity resulting in pharmacological interactions. Nomegestrol acetate (NMGA) is a progestogen increasingly used in contraceptiv...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
06 July 2018
|
| In: |
European journal of pharmaceutical sciences
Year: 2018, Jahrgang: 122, Pages: 205-213 |
| ISSN: | 1879-0720 |
| DOI: | 10.1016/j.ejps.2018.07.017 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.ejps.2018.07.017 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0928098718303154 
|
| Verfasserangaben: | Guillermo Nicolás Tocchetti, Camila Juliana Domínguez, Felipe Zecchinati, Maite Rocío Arana, María Laura Ruiz, Silvina Stella Maris Villanueva, Aldo Domingo Mottino, Johanna Weiss, Juan Pablo Rigalli |
Search Result 1
Low risk of the TMPRSS2 inhibitor camostat mesylate and its metabolite GBPA to act as perpetrators of drug-drug interactions
Article (Journal)
Online Resource