Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior
Disruptive behavior is associated with societally and personally problematic levels of aggression and has been linked to abnormal structure and function of fronto-amygdala-striatal regions. Abnormal glutamatergic signalling within this network may play a role in aggression. However, disruptive behav...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 September 2019
|
| In: |
Cortex
Year: 2019, Jahrgang: 121, Pages: 135-146 |
| ISSN: | 1973-8102 |
| DOI: | 10.1016/j.cortex.2019.08.017 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.cortex.2019.08.017 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0010945219303065 
|
| Verfasserangaben: | Michael C. Craig, Leandra M. Mulder, Marcel P. Zwiers, Arjun Sethi, Pieter J. Hoekstra, Andrea Dietrich, Sarah Baumeister, Pascal M. Aggensteiner, Tobias Banaschewski, Daniel Brandeis, Julia E. Werhahn, Susanne Walitza, Josefina Castro-Fornieles, Celso Arango, Ulrike M.E. Schulze, Jeffrey C. Glennon, Barbara Franke, Paramala J. Santosh, Mathilde Mastroianni, Jack J.A. van Asten, Jan K. Buitelaar, David J. Lythgoe and Jilly Naaijen |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 169139243X | ||
| 003 | DE-627 | ||
| 005 | 20240404193256.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200303s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.cortex.2019.08.017 |2 doi | |
| 035 | |a (DE-627)169139243X | ||
| 035 | |a (DE-599)KXP169139243X | ||
| 035 | |a (OCoLC)1341308681 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Craig, Michael |e VerfasserIn |0 (DE-588)120574987X |0 (DE-627)1691393789 |4 aut | |
| 245 | 1 | 0 | |a Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior |c Michael C. Craig, Leandra M. Mulder, Marcel P. Zwiers, Arjun Sethi, Pieter J. Hoekstra, Andrea Dietrich, Sarah Baumeister, Pascal M. Aggensteiner, Tobias Banaschewski, Daniel Brandeis, Julia E. Werhahn, Susanne Walitza, Josefina Castro-Fornieles, Celso Arango, Ulrike M.E. Schulze, Jeffrey C. Glennon, Barbara Franke, Paramala J. Santosh, Mathilde Mastroianni, Jack J.A. van Asten, Jan K. Buitelaar, David J. Lythgoe and Jilly Naaijen |
| 264 | 1 | |c 19 September 2019 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.03.2020 | ||
| 520 | |a Disruptive behavior is associated with societally and personally problematic levels of aggression and has been linked to abnormal structure and function of fronto-amygdala-striatal regions. Abnormal glutamatergic signalling within this network may play a role in aggression. However, disruptive behavior does not represent a homogeneous construct, but can be fractionated across several dimensions. Of particular interest, callous-unemotional (CU) traits have been shown to modulate the severity, neural and behavioural characterisation, and therapeutic outcomes of disruptive behaviour disorders (DBDs) and aggression. Further, individuals showing disruptive behavior differ to the extent that they engage in subtypes of aggression (i.e., proactive [PA] and reactive aggression [RA]) which may also represent distinct therapeutic targets. Here we investigated how glutamate signalling within the fronto-amygdala-striatal circuitry was altered along these dimensions in youths showing disruptive behavior (n = 140) and typically developing controls (TD, n = 93) within the age-range of 8-18 years. We used proton magnetic resonance spectroscopy (1H-MRS) in the anterior cingulate cortex (ACC), striatum, amygdala and insula and associated glutamate concentrations with continuous measures of aggression and CU-traits using linear mixed-effects models. We found evidence of a dissociation for the different measures and glutamate concentrations. CU traits were associated with increased ACC glutamate (‘callousness’: b = .19, t (108) = 2.63, p = .01, r = .25; ‘uncaring’: b = .18, t (108) = 2.59, p = .011, r = .24) while PA was associated with decreased striatal glutamate concentration (b = −.23, t (28) = -3.02, p = .005, r = .50). These findings suggest dissociable correlates of CU traits and PA in DBDs, and indicate that the ACC and striatal glutamate may represent novel pharmacological targets in treating these different aspects. | ||
| 650 | 4 | |a Aggression | |
| 650 | 4 | |a Anterior cingulate cortex | |
| 650 | 4 | |a Callous unemotional traits | |
| 650 | 4 | |a Glutamate | |
| 650 | 4 | |a Magnetic resonance spectroscopy | |
| 700 | 1 | |a Mulder, Leandra M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zwiers, Marcel P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sethi, Arjun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hoekstra, Pieter J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dietrich, Andrea |e VerfasserIn |4 aut | |
| 700 | 1 | |a Baumeister, Sarah |d 1983- |e VerfasserIn |0 (DE-588)1060062402 |0 (DE-627)799202754 |0 (DE-576)416162134 |4 aut | |
| 700 | 1 | |a Aggensteiner, Pascal |d 1987- |e VerfasserIn |0 (DE-588)1158624700 |0 (DE-627)1020605839 |0 (DE-576)504252496 |4 aut | |
| 700 | 1 | |a Banaschewski, Tobias |d 1961- |e VerfasserIn |0 (DE-588)115856110 |0 (DE-627)507227301 |0 (DE-576)178364703 |4 aut | |
| 700 | 1 | |a Brandeis, Daniel |e VerfasserIn |0 (DE-588)1028379153 |0 (DE-627)730634477 |0 (DE-576)375917896 |4 aut | |
| 700 | 1 | |a Werhahn, Julia E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Walitza, Susanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Castro-Fornieles, Josefina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Arango, Celso |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schulze, Ulrike M. E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Glennon, Jeffrey C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Franke, Barbara |e VerfasserIn |4 aut | |
| 700 | 1 | |a Santosh, Paramala J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mastroianni, Mathilde |e VerfasserIn |4 aut | |
| 700 | 1 | |a van Asten, Jack J. A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Buitelaar, Jan K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lythgoe, David J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Naaijen, Jilly |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cortex |d Paris : Elsevier Masson, 1964 |g 121(2019), Seite 135-146 |h Online-Ressource |w (DE-627)349234906 |w (DE-600)2080335-7 |w (DE-576)121747050 |x 1973-8102 |7 nnas |a Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior |
| 773 | 1 | 8 | |g volume:121 |g year:2019 |g pages:135-146 |g extent:12 |a Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.cortex.2019.08.017 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0010945219303065 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200303 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1028379153 |a Brandeis, Daniel |m 1028379153:Brandeis, Daniel |d 60000 |e 60000PB1028379153 |k 0/60000/ |p 10 | ||
| 998 | |g 115856110 |a Banaschewski, Tobias |m 115856110:Banaschewski, Tobias |d 60000 |e 60000PB115856110 |k 0/60000/ |p 9 | ||
| 998 | |g 1158624700 |a Aggensteiner, Pascal |m 1158624700:Aggensteiner, Pascal |d 60000 |e 60000PA1158624700 |k 0/60000/ |p 8 | ||
| 998 | |g 1060062402 |a Baumeister, Sarah |m 1060062402:Baumeister, Sarah |d 60000 |e 60000PB1060062402 |k 0/60000/ |p 7 | ||
| 999 | |a KXP-PPN169139243X |e 3602570169 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"role":"aut","given":"Michael","family":"Craig","display":"Craig, Michael"},{"family":"Mulder","display":"Mulder, Leandra M.","given":"Leandra M.","role":"aut"},{"given":"Marcel P.","role":"aut","family":"Zwiers","display":"Zwiers, Marcel P."},{"given":"Arjun","role":"aut","display":"Sethi, Arjun","family":"Sethi"},{"family":"Hoekstra","display":"Hoekstra, Pieter J.","given":"Pieter J.","role":"aut"},{"given":"Andrea","role":"aut","display":"Dietrich, Andrea","family":"Dietrich"},{"role":"aut","given":"Sarah","display":"Baumeister, Sarah","family":"Baumeister"},{"family":"Aggensteiner","display":"Aggensteiner, Pascal","role":"aut","given":"Pascal"},{"given":"Tobias","role":"aut","display":"Banaschewski, Tobias","family":"Banaschewski"},{"family":"Brandeis","display":"Brandeis, Daniel","role":"aut","given":"Daniel"},{"given":"Julia E.","role":"aut","display":"Werhahn, Julia E.","family":"Werhahn"},{"given":"Susanne","role":"aut","family":"Walitza","display":"Walitza, Susanne"},{"display":"Castro-Fornieles, Josefina","family":"Castro-Fornieles","given":"Josefina","role":"aut"},{"role":"aut","given":"Celso","family":"Arango","display":"Arango, Celso"},{"role":"aut","given":"Ulrike M. E.","family":"Schulze","display":"Schulze, Ulrike M. E."},{"family":"Glennon","display":"Glennon, Jeffrey C.","role":"aut","given":"Jeffrey C."},{"given":"Barbara","role":"aut","family":"Franke","display":"Franke, Barbara"},{"family":"Santosh","display":"Santosh, Paramala J.","given":"Paramala J.","role":"aut"},{"role":"aut","given":"Mathilde","display":"Mastroianni, Mathilde","family":"Mastroianni"},{"display":"van Asten, Jack J. A.","family":"van Asten","given":"Jack J. A.","role":"aut"},{"display":"Buitelaar, Jan K.","family":"Buitelaar","role":"aut","given":"Jan K."},{"role":"aut","given":"David J.","family":"Lythgoe","display":"Lythgoe, David J."},{"display":"Naaijen, Jilly","family":"Naaijen","role":"aut","given":"Jilly"}],"id":{"doi":["10.1016/j.cortex.2019.08.017"],"eki":["169139243X"]},"recId":"169139243X","relHost":[{"language":["eng"],"part":{"extent":"12","text":"121(2019), Seite 135-146","volume":"121","year":"2019","pages":"135-146"},"title":[{"title":"Cortex","title_sort":"Cortex","subtitle":"a journal devoted to the study of the nervous system and behaviour"}],"pubHistory":["1.1964/65 -"],"origin":[{"publisherPlace":"Paris ; New York, NY ; [Erscheinungsort nicht ermittelbar]","dateIssuedDisp":"1964-","publisher":"Elsevier Masson ; Elsevier ; Masson","dateIssuedKey":"1964"}],"note":["Gesehen am 04.02.20"],"disp":"Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behaviorCortex","type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"349234906","id":{"eki":["349234906"],"issn":["1973-8102"],"zdb":["2080335-7"]}}],"physDesc":[{"extent":"12 S."}],"name":{"displayForm":["Michael C. Craig, Leandra M. Mulder, Marcel P. Zwiers, Arjun Sethi, Pieter J. Hoekstra, Andrea Dietrich, Sarah Baumeister, Pascal M. Aggensteiner, Tobias Banaschewski, Daniel Brandeis, Julia E. Werhahn, Susanne Walitza, Josefina Castro-Fornieles, Celso Arango, Ulrike M.E. Schulze, Jeffrey C. Glennon, Barbara Franke, Paramala J. Santosh, Mathilde Mastroianni, Jack J.A. van Asten, Jan K. Buitelaar, David J. Lythgoe and Jilly Naaijen"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior","title":"Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior"}],"note":["Gesehen am 03.03.2020"],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"19 September 2019"}]} | ||
| SRT | |a CRAIGMICHADISTINCTAS1920 | ||