Androgen receptor expression and response to chemotherapy in breast cancer patients treated in the neoadjuvant TECHNO and PREPARE trial
The androgen receptor (AR) is discussed as a prognostic and/or predictive marker in breast cancer patients. AR mRNA expression was analysed by RT-qPCR in breast cancer patients treated in the neoadjuvant TECHNO (n = 118, HER2-positive) and PREPARE trial (n = 321, HER2-positive and -negative). In...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 November 2019
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| In: |
British journal of cancer
Year: 2019, Jahrgang: 121, Heft: 12, Pages: 1009-1015 |
| ISSN: | 1532-1827 |
| DOI: | 10.1038/s41416-019-0630-3 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/s41416-019-0630-3 Verlag: https://www.nature.com/articles/s41416-019-0630-3 
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| Verfasserangaben: | Isabell Witzel, Sibylle Loibl, Ralph Wirtz, Peter A. Fasching, Carsten Denkert, Karsten Weber, Hans-Joachim Lück, Jens Huober, Thomas Karn, Marion von Mackelenbergh, Frederik Marmé, Christian Schem, Elmar Stickeler, Michael Untch, Volkmar Müller |
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| 245 | 1 | 0 | |a Androgen receptor expression and response to chemotherapy in breast cancer patients treated in the neoadjuvant TECHNO and PREPARE trial |c Isabell Witzel, Sibylle Loibl, Ralph Wirtz, Peter A. Fasching, Carsten Denkert, Karsten Weber, Hans-Joachim Lück, Jens Huober, Thomas Karn, Marion von Mackelenbergh, Frederik Marmé, Christian Schem, Elmar Stickeler, Michael Untch, Volkmar Müller |
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| 520 | |a The androgen receptor (AR) is discussed as a prognostic and/or predictive marker in breast cancer patients. AR mRNA expression was analysed by RT-qPCR in breast cancer patients treated in the neoadjuvant TECHNO (n = 118, HER2-positive) and PREPARE trial (n = 321, HER2-positive and -negative). In addition, mRNA expression of the AR transcript variants 1 (AR1) and 2 (AR2) was measured. Regarding subtypes, high AR mRNA levels were frequent in HER2-positive (61.3%, 92/150) and luminal tumours (60.0%, 96/160) but almost absent in triple-negative tumours (4.3%, 3/69) (p < 0.0001). Overall, high AR mRNA levels were found to be associated with lower pathological complete remission (pCR) rates (OR 0.77 per unit, 95% CI 0.67-0.88, p = 0.0002) but also with better prognosis in terms of longer disease-free survival (DFS) (HR 0.57, 95% CI 0.39-0.85, p = 0.0054) and overall survival (OS) (HR 0.43, 95% CI, 0.26-0.71, p = 0.0011). In the PREPARE trial, a survival difference for patients with high and low AR1 mRNA levels could only be seen in the standard chemotherapy arm but not in the dose-dense treatment arm (OS: HR 0.41; 95% CI 0.22-0.74 vs. HR 1.05; 95% CI 0.52-2.13; p = 0.0459). We provide evidence that AR mRNA predicts response to chemotherapy in breast cancer patients. | ||
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| 700 | 1 | |a Denkert, Carsten |e VerfasserIn |4 aut | |
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