Harmonization and standardization of panel-based tumor mutational burden (TMB) measurement: real-world results and recommendations of the QuIP study
Tumor mutational burden (TMB) is a quantitative assessment of the number of somatic mutations within a tumor genome. Immunotherapy benefit has been associated with TMB assessed by whole exome sequencing (wesTMB) and by gene panel sequencing (psTMB). The initiatives of Quality in Pathology (QuIP) and...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 February 2020
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| In: |
Journal of thoracic oncology
Year: 2020, Jahrgang: 15, Heft: 7, Pages: 1177-1189 |
| ISSN: | 1556-1380 |
| DOI: | 10.1016/j.jtho.2020.01.023 |
| Online-Zugang: | Resolving-System, Volltext: https://doi.org/10.1016/j.jtho.2020.01.023 Verlag: https://www.sciencedirect.com/science/article/abs/pii/S1556086420301350?via%3Dihub 
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| Verfasserangaben: | Albrecht Stenzinger, Volker Endris, Jan Budczies, Sabine Merkelbach-Bruse, Daniel Kazdal, Wolfgang Dietmaier, Nicole Pfarr, Udo Siebolts, Michael Hummel, Sylvia Herold, Johanna Andreas, Martin Zoche, Lars Tögel, Eugen Rempel, Jörg Maas, Diana Merino, Mark Stewart, Karim Zaoui, Matthias Schlesner, Hanno Glimm, Stefan Fröhling, Jeff Allen, David Horst, Gustavo Baretton, Claudia Wickenhauser, Markus Tiemann, Matthias Evert, Holger Moch, Thomas Kirchner, Reinhard Büttner, Peter Schirmacher, Andreas Jung, Florian Haller, Wilko Weichert, Manfred Dietel |
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| 520 | |a Tumor mutational burden (TMB) is a quantitative assessment of the number of somatic mutations within a tumor genome. Immunotherapy benefit has been associated with TMB assessed by whole exome sequencing (wesTMB) and by gene panel sequencing (psTMB). The initiatives of Quality in Pathology (QuIP) and Friends of Cancer Research (FoCR) have jointly addressed the need for harmonization between TMB testing options in tissues. This QuIP study identifies critical sources of variation in psTMB assessment. | ||
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