Quick flicks: association of paroxysmal kinesigenic dyskinesia and tics
Background: Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterised by brief attacks of chorea, dystonia, or mixed forms precipitated by sudden movement. Methods: Observational study with a cohort of 14 PKD patients and genetic testing for PRRT2 mutations. Results: In a series of 1...
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
06 April 2018
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Movement disorders clinical practice
Year: 2018, Jahrgang: 5, Heft: 3, Pages: 317-320 |
| ISSN: | 2330-1619 |
| DOI: | 10.1002/mdc3.12615 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1002/mdc3.12615 Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1002/mdc3.12615 
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| Verfasserangaben: | Bettina Balint, Sarah Wiethoff, Davide Martino, Claudia del Gamba, Anna Latorre, Christos Ganos, Henry Houlden, and Kailash P. Bhatia |
| Zusammenfassung: | Background: Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterised by brief attacks of chorea, dystonia, or mixed forms precipitated by sudden movement. Methods: Observational study with a cohort of 14 PKD patients and genetic testing for PRRT2 mutations. Results: In a series of 14 PKD patients seen in our clinic at the National Hospital of Neurology, Queen Square, from 2012-2017, we noted tics in 11 patients (79%), which stand in stark contrast to the estimated lifetime prevalence of tics estimated to reach 1%. Conclusions: The two reasons to point out this possible association are the clinical implications and the potential opportunity of a better understanding of shared pathophysiological mechanisms of neuronal hyperexcitability. |
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| Beschreibung: | Gesehen am 03.04.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 2330-1619 |
| DOI: | 10.1002/mdc3.12615 |