A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer
Background - Perioperative chemotherapy is an established treatment of advanced gastric cancer patients. Treatment selection is based on clinical staging (cT). We aimed to establish and validate a prognostic score including clinical and molecular factors, to optimize treatment decisions for these pa...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
|
| In: |
Annals of oncology
Year: 2018, Volume: 29, Issue: 1, Pages: 127-132 |
| ISSN: | 1569-8041 |
| DOI: | 10.1093/annonc/mdx685 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1093/annonc/mdx685 Verlag: http://www.sciencedirect.com/science/article/pii/S0923753419350057 
|
| Author Notes: | L. Bauer, A. Hapfelmeier, S. Blank, M. Reiche, J. Slotta-Huspenina, M. Jesinghaus, A. Novotny, T. Schmidt, B. Grosser, M. Kohlruss, W. Weichert, K. Ott & G. Keller |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1691754986 | ||
| 003 | DE-627 | ||
| 005 | 20250828161728.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200305s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/annonc/mdx685 |2 doi | |
| 035 | |a (DE-627)1691754986 | ||
| 035 | |a (DE-599)KXP1691754986 | ||
| 035 | |a (OCoLC)1341309507 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bauer, Lukas |e VerfasserIn |0 (DE-588)1170929842 |0 (DE-627)1040251269 |0 (DE-576)512726876 |4 aut | |
| 245 | 1 | 2 | |a A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer |c L. Bauer, A. Hapfelmeier, S. Blank, M. Reiche, J. Slotta-Huspenina, M. Jesinghaus, A. Novotny, T. Schmidt, B. Grosser, M. Kohlruss, W. Weichert, K. Ott & G. Keller |
| 264 | 1 | |c 2018 | |
| 264 | 4 | |c 2020 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.03.2020 | ||
| 500 | |a Elektronische Reproduktion der Druckausgabe | ||
| 520 | |a Background - Perioperative chemotherapy is an established treatment of advanced gastric cancer patients. Treatment selection is based on clinical staging (cT). We aimed to establish and validate a prognostic score including clinical and molecular factors, to optimize treatment decisions for these patients. - Patients and methods - We analyzed 626 carcinomas of the stomach and of the gastro-esophageal junction from two academic centers including primarily resected and pre-/perioperatively treated patients. Patients were divided into a training (N = 269) and validation (N = 357) set. Expression of 11 target genes was measured by quantitative PCR in resected tumors. A risk score to predict overall survival (OS) was generated and validated. Intra-tumoral heterogeneity was assessed by analyzing 50 tumor areas from 10 patients. - Results - A risk score including the expression of CCL5, CTNNB1, EXOSC3 and LZTR1 and the clinical parameters cT, tumor localization and histopathologic type suggested two groups with a significant difference in OS [hazard ratio (HR) 0.30; 95% confidence interval (CI) 0.17-0.52]. The risk score was successfully validated in an independent cohort (HR 0.32; 95% CI 0.21-0.51; P < 0.001) as well as in subgroups of primarily resected (HR 0.30; 95% CI 0.17-0.54; P < 0.001) and pre-/perioperatively treated patients (HR 0.37; 95% CI 0.17-0.81; P = 0.009). A significant difference in OS of high- and low-risk patients was also found in primarily resected patients with intestinal (HR 0.45; 95% CI 0.23-0.90; P = 0.020) and nonintestinal-type carcinomas (HR 0.1; 95% CI 0.02-0.42; P < 0.001). Intra-tumor heterogeneity analysis indicated a classification reliability of 95% for a supposed analysis of three biopsies. - Conclusion - The identified risk score could substantially contribute to an improved management of gastric cancer patients in the context of perioperative chemotherapy. | ||
| 650 | 4 | |a gastric carcinoma | |
| 650 | 4 | |a gene expression | |
| 650 | 4 | |a perioperative chemotherapy | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a risk score | |
| 700 | 1 | |a Blank, Susanne |d 1984- |e VerfasserIn |0 (DE-588)1014414253 |0 (DE-627)705225097 |0 (DE-576)34875714X |4 aut | |
| 700 | 1 | |a Schmidt, Thomas |d 1980- |e VerfasserIn |0 (DE-588)132383152 |0 (DE-627)521950023 |0 (DE-576)260799149 |4 aut | |
| 700 | 1 | |a Weichert, Wilko |d 1970-2023 |e VerfasserIn |0 (DE-588)123509106 |0 (DE-627)56134650X |0 (DE-576)293740461 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of oncology |d Amsterdam [u.a.] : Elsevier, 1990 |g 29(2018), 1, Seite 127-132 |h Online-Ressource |w (DE-627)320428796 |w (DE-600)2003498-2 |w (DE-576)098134345 |x 1569-8041 |7 nnas |a A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer |
| 773 | 1 | 8 | |g volume:29 |g year:2018 |g number:1 |g pages:127-132 |g extent:6 |a A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1093/annonc/mdx685 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0923753419350057 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20200305 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 132383152 |a Schmidt, Thomas |m 132383152:Schmidt, Thomas |d 910000 |d 910200 |d 50000 |e 910000PS132383152 |e 910200PS132383152 |e 50000PS132383152 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 8 | ||
| 998 | |g 1014414253 |a Blank, Susanne |m 1014414253:Blank, Susanne |d 910000 |d 910200 |e 910000PB1014414253 |e 910200PB1014414253 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 999 | |a KXP-PPN1691754986 |e 360400134X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"2018"}],"id":{"eki":["1691754986"],"doi":["10.1093/annonc/mdx685"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"person":[{"role":"aut","family":"Bauer","display":"Bauer, Lukas","given":"Lukas"},{"role":"aut","family":"Blank","display":"Blank, Susanne","given":"Susanne"},{"display":"Schmidt, Thomas","family":"Schmidt","given":"Thomas","role":"aut"},{"given":"Wilko","family":"Weichert","display":"Weichert, Wilko","role":"aut"}],"physDesc":[{"extent":"6 S."}],"title":[{"title":"A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer","title_sort":"novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer"}],"relHost":[{"disp":"A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancerAnnals of oncology","recId":"320428796","pubHistory":["1.1990 -"],"note":["Gesehen am 12.11.20","Ungezählte Beil.: Supplement"],"origin":[{"publisher":"Elsevier ; Kluwer ; Oxford Univ. Press","dateIssuedKey":"1990","publisherPlace":"Amsterdam [u.a.] ; Dordrecht [u.a.] ; Oxford","dateIssuedDisp":"1990-"}],"corporate":[{"role":"isb","display":"European Society for Medical Oncology"}],"id":{"issn":["1569-8041"],"zdb":["2003498-2"],"eki":["320428796"]},"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"volume":"29","text":"29(2018), 1, Seite 127-132","pages":"127-132","extent":"6","year":"2018","issue":"1"},"title":[{"title":"Annals of oncology","subtitle":"official journal of the European Society for Medical Oncology","title_sort":"Annals of oncology"}],"physDesc":[{"extent":"Online-Ressource"}]}],"name":{"displayForm":["L. Bauer, A. Hapfelmeier, S. Blank, M. Reiche, J. Slotta-Huspenina, M. Jesinghaus, A. Novotny, T. Schmidt, B. Grosser, M. Kohlruss, W. Weichert, K. Ott & G. Keller"]},"note":["Gesehen am 05.03.2020","Elektronische Reproduktion der Druckausgabe"],"recId":"1691754986"} | ||
| SRT | |a BAUERLUKASNOVELPRETH2018 | ||