Lamin-B1 is a senescence-associated biomarker in clear-cell renal cell carcinoma
Clear-cell renal cell carcinoma (ccRCC) is a von-Hippel-Lindau gene (VHL) associated tumor disease. In addition to activating the hypoxia inducible factor (HIF) dependent oxygen-sensing pathway, VHL loss also has an impact on a HIF-independent senescence program which functions as a tumorigenesis ba...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 9, 2019
|
| In: |
Oncology letters
Year: 2019, Jahrgang: 18, Heft: 3, Pages: 2654-2660 |
| ISSN: | 1792-1082 |
| DOI: | 10.3892/ol.2019.10593 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3892/ol.2019.10593
|
| Verfasserangaben: | Melissa Marie Radspieler, Mario Schindeldecker, Philipp Stenzel, Sebastian Försch, Katrin E. Tagscherer, Esther Herpel, Markus Hohenfellner, Gencay Hatiboglu, Wilfried Roth, Stephan Macher-Goeppinger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 169176146X | ||
| 003 | DE-627 | ||
| 005 | 20230426073015.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200305s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3892/ol.2019.10593 |2 doi | |
| 035 | |a (DE-627)169176146X | ||
| 035 | |a (DE-599)KXP169176146X | ||
| 035 | |a (OCoLC)1341309370 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Radspieler, Melissa Marie |e VerfasserIn |0 (DE-588)120591904X |0 (DE-627)1691762997 |4 aut | |
| 245 | 1 | 0 | |a Lamin-B1 is a senescence-associated biomarker in clear-cell renal cell carcinoma |c Melissa Marie Radspieler, Mario Schindeldecker, Philipp Stenzel, Sebastian Försch, Katrin E. Tagscherer, Esther Herpel, Markus Hohenfellner, Gencay Hatiboglu, Wilfried Roth, Stephan Macher-Goeppinger |
| 264 | 1 | |c July 9, 2019 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.03.2020 | ||
| 520 | |a Clear-cell renal cell carcinoma (ccRCC) is a von-Hippel-Lindau gene (VHL) associated tumor disease. In addition to activating the hypoxia inducible factor (HIF) dependent oxygen-sensing pathway, VHL loss also has an impact on a HIF-independent senescence program which functions as a tumorigenesis barrier. Lamin-B1 is a nuclear intermediate filament protein that exhibits effects on chromatin structure and gene expression and acts as a senescence effector. In the present study, the expression and prognostic relevance of Lamin-B1 in a large cohort of ccRCC patients was examined and the report presents initial functional data on possible therapeutic implications. The expression of Lamin-B1 was measured by immunohistochemistry using a tissue microarray containing tumor tissue samples from 763 ccRCC patients. Chi-squared tests, Kaplan-Meier curves and Cox regression models were used to investigate the possible association between Lamin-B1 expression, clinical and pathological characteristics and patient survival. High Lamin-B1 expression was associated with poor clinical outcomes and multivariate Cox regression analyses revealed that Lamin-B1 was an independent prognostic factor for cancer-specific survival. Furthermore in vitro data suggested that Lamin-B1 acted as a functional downstream senescence effector in RCC cell lines. In conclusion, patients affected by ccRCC with high Lamin-B1 expression exhibit poor prognosis. Lamin-B1 may serve as a tissue-based biomarker for new therapeutic agents targeting therapy-induced senescence. | ||
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a kidney | |
| 650 | 4 | |a lamin-B1 | |
| 650 | 4 | |a renal cell carcinoma | |
| 650 | 4 | |a senescence | |
| 700 | 1 | |a Schindeldecker, Mario |d 1978- |e VerfasserIn |0 (DE-588)1072567563 |0 (DE-627)827735170 |0 (DE-576)434039918 |4 aut | |
| 700 | 1 | |a Stenzel, Philipp J. |e VerfasserIn |0 (DE-588)120729523X |0 (DE-627)1693500027 |4 aut | |
| 700 | 1 | |a Försch, Sebastian |d 1985- |e VerfasserIn |0 (DE-588)1018553894 |0 (DE-627)682860832 |0 (DE-576)356024814 |4 aut | |
| 700 | 1 | |a Tagscherer, Katrin |e VerfasserIn |0 (DE-588)138997543 |0 (DE-627)703175580 |0 (DE-576)309386039 |4 aut | |
| 700 | 1 | |a Herpel, Esther |d 1973- |e VerfasserIn |0 (DE-588)12965227X |0 (DE-627)476593662 |0 (DE-576)297767984 |4 aut | |
| 700 | 1 | |a Hohenfellner, Markus |d 1958- |e VerfasserIn |0 (DE-588)133862518 |0 (DE-627)557857988 |0 (DE-576)300155263 |4 aut | |
| 700 | 1 | |a Hatiboglu, Gencay |d 1979- |e VerfasserIn |0 (DE-588)132495139 |0 (DE-627)522966845 |0 (DE-576)299182673 |4 aut | |
| 700 | 1 | |a Roth, Wilfried |d 1970- |e VerfasserIn |0 (DE-588)120891557 |0 (DE-627)080951279 |0 (DE-576)292433484 |4 aut | |
| 700 | 1 | |a Macher-Göppinger, Stephan |e VerfasserIn |0 (DE-588)1022394061 |0 (DE-627)716963299 |0 (DE-576)365275034 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Oncology letters |d Athens : Spandidos Publ., 2010 |g 18(2019), 3, Seite 2654-2660 |h Online-Ressource |w (DE-627)635601389 |w (DE-600)2573196-8 |w (DE-576)372066399 |x 1792-1082 |7 nnas |a Lamin-B1 is a senescence-associated biomarker in clear-cell renal cell carcinoma |
| 773 | 1 | 8 | |g volume:18 |g year:2019 |g number:3 |g pages:2654-2660 |g extent:7 |a Lamin-B1 is a senescence-associated biomarker in clear-cell renal cell carcinoma |
| 856 | 4 | 0 | |u https://doi.org/10.3892/ol.2019.10593 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200305 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 132495139 |a Hatiboglu, Gencay |m 132495139:Hatiboglu, Gencay |d 910000 |d 910200 |e 910000PH132495139 |e 910200PH132495139 |k 0/910000/ |k 1/910000/910200/ |p 8 | ||
| 998 | |g 133862518 |a Hohenfellner, Markus |m 133862518:Hohenfellner, Markus |d 910000 |d 910200 |e 910000PH133862518 |e 910200PH133862518 |k 0/910000/ |k 1/910000/910200/ |p 7 | ||
| 998 | |g 12965227X |a Herpel, Esther |m 12965227X:Herpel, Esther |d 910000 |d 912000 |e 910000PH12965227X |e 912000PH12965227X |k 0/910000/ |k 1/910000/912000/ |p 6 | ||
| 999 | |a KXP-PPN169176146X |e 3604018307 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"July 9, 2019","dateIssuedKey":"2019"}],"person":[{"family":"Radspieler","given":"Melissa Marie","role":"aut","display":"Radspieler, Melissa Marie"},{"family":"Schindeldecker","role":"aut","given":"Mario","display":"Schindeldecker, Mario"},{"display":"Stenzel, Philipp J.","given":"Philipp J.","role":"aut","family":"Stenzel"},{"display":"Försch, Sebastian","given":"Sebastian","role":"aut","family":"Försch"},{"family":"Tagscherer","given":"Katrin","role":"aut","display":"Tagscherer, Katrin"},{"family":"Herpel","role":"aut","given":"Esther","display":"Herpel, Esther"},{"given":"Markus","role":"aut","family":"Hohenfellner","display":"Hohenfellner, Markus"},{"display":"Hatiboglu, Gencay","family":"Hatiboglu","role":"aut","given":"Gencay"},{"role":"aut","given":"Wilfried","family":"Roth","display":"Roth, Wilfried"},{"display":"Macher-Göppinger, Stephan","family":"Macher-Göppinger","role":"aut","given":"Stephan"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"recId":"635601389","disp":"Lamin-B1 is a senescence-associated biomarker in clear-cell renal cell carcinomaOncology letters","origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"2010-","publisherPlace":"Athens","publisher":"Spandidos Publ."}],"pubHistory":["1.2010 -"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 12.10.2020","Volltext auch als Teil einer Datenbank verfügbar"],"id":{"issn":["1792-1082"],"eki":["635601389"],"zdb":["2573196-8"]},"part":{"issue":"3","text":"18(2019), 3, Seite 2654-2660","extent":"7","pages":"2654-2660","volume":"18","year":"2019"},"title":[{"title_sort":"Oncology letters","title":"Oncology letters"}]}],"title":[{"title":"Lamin-B1 is a senescence-associated biomarker in clear-cell renal cell carcinoma","title_sort":"Lamin-B1 is a senescence-associated biomarker in clear-cell renal cell carcinoma"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 05.03.2020"],"recId":"169176146X","physDesc":[{"extent":"7 S."}],"name":{"displayForm":["Melissa Marie Radspieler, Mario Schindeldecker, Philipp Stenzel, Sebastian Försch, Katrin E. Tagscherer, Esther Herpel, Markus Hohenfellner, Gencay Hatiboglu, Wilfried Roth, Stephan Macher-Goeppinger"]},"id":{"doi":["10.3892/ol.2019.10593"],"eki":["169176146X"]}} | ||
| SRT | |a RADSPIELERLAMINB1ISA9201 | ||