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Real-time inverse high-dose-rate brachytherapy planning with catheter optimization by compressed sensing-inspired optimization strategies

This paper demonstrates that optimization strategies derived from the field of compressed sensing (CS) improve computational performance in inverse treatment planning (ITP) for high-dose-rate (HDR) brachytherapy. Following an approach applied to low-dose-rate brachytherapy, we developed a reformulat...

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Bibliographische Detailangaben
Hauptverfasser: Stump-Guthier, Carolin (VerfasserIn) , Aschenbrenner, Katharina P. (VerfasserIn) , Wittmayer, Lisa (VerfasserIn) , Hesser, Jürgen (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 20 July 2016
In: Physics in medicine and biology
Year: 2016, Jahrgang: 61, Heft: 16, Pages: 5956-5972
ISSN:1361-6560
DOI:10.1088/0031-9155/61/16/5956
Online-Zugang:Verlag, Volltext: https://doi.org/10.1088/0031-9155/61/16/5956
Verlag: https://doi.org/10.1088%2F0031-9155%2F61%2F16%2F5956
Volltext
Verfasserangaben:C.V. Guthier, K.P. Aschenbrenner, R. Müller, L. Polster, R.A. Cormack and J.W. Hesser
Beschreibung
Zusammenfassung:This paper demonstrates that optimization strategies derived from the field of compressed sensing (CS) improve computational performance in inverse treatment planning (ITP) for high-dose-rate (HDR) brachytherapy. Following an approach applied to low-dose-rate brachytherapy, we developed a reformulation of the ITP problem with the same mathematical structure as standard CS problems. Two greedy methods, derived from hard thresholding and subspace pursuit are presented and their performance is compared to state-of-the-art ITP solvers. Applied to clinical prostate brachytherapy plans speed-up by a factor of 56-350 compared to state-of-the-art methods. Based on a Wilcoxon signed rank-test the novel method statistically significantly decreases the final objective function value (p < 0.01). The optimization times were below one second and thus planing can be considered as real-time capable. The novel CS inspired strategy enables real-time ITP for HDR brachytherapy including catheter optimization. The generated plans are either clinically equivalent or show a better performance with respect to dosimetric measures.
Beschreibung:Gesehen am 05.03.2020
Beschreibung:Online Resource
ISSN:1361-6560
DOI:10.1088/0031-9155/61/16/5956

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