Prolonged antibiotic prophylaxis after thoracoabdominal esophagectomy does not reduce the risk of pneumonia in the first 30 days: a retrospective before-and-after analysis
Purpose: Thoracoabdominal esophageal resection for malignant disease is frequently associated with pulmonary infection. Whether prolonged antibiotic prophylaxis beyond a single perioperative dose is advantageous in preventing pulmonary infection after thoracoabdominal esophagectomy remains unclear....
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
05 June 2018
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| In: |
Infection
Year: 2018, Volume: 46, Issue: 5, Pages: 617-624 |
| ISSN: | 1439-0973 |
| DOI: | 10.1007/s15010-018-1160-2 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s15010-018-1160-2
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| Author Notes: | Marcel Hochreiter, Maria Uhling, Leila Sisic, Thomas Bruckner, Alexandra Heininger, Andreas Hohn, Katja Ott, Thomas Schmidt, Marc Moritz Berger, Daniel Christoph Richter, Markus Büchler, Markus Alexander Weigand, Cornelius Johannes Busch |
MARC
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| 245 | 1 | 0 | |a Prolonged antibiotic prophylaxis after thoracoabdominal esophagectomy does not reduce the risk of pneumonia in the first 30 days |b a retrospective before-and-after analysis |c Marcel Hochreiter, Maria Uhling, Leila Sisic, Thomas Bruckner, Alexandra Heininger, Andreas Hohn, Katja Ott, Thomas Schmidt, Marc Moritz Berger, Daniel Christoph Richter, Markus Büchler, Markus Alexander Weigand, Cornelius Johannes Busch |
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| 520 | |a Purpose: Thoracoabdominal esophageal resection for malignant disease is frequently associated with pulmonary infection. Whether prolonged antibiotic prophylaxis beyond a single perioperative dose is advantageous in preventing pulmonary infection after thoracoabdominal esophagectomy remains unclear. Methods: In this retrospective before-and-after analysis, 173 patients between January 2009 and December 2014 from a prospectively maintained database were included. We evaluated the effect of a 5-day postoperative course of moxifloxacin, which is a frequently used antimicrobial agent for pneumonia, on the incidence of pulmonary infection and mortality after thoracoabdominal esophagectomy. Results: 104 patients received only perioperative antimicrobial prophylaxis (control group) and 69 additionally received a 5-day postoperative antibiotic therapy with moxifloxacin (prolonged-course). 22 (12.7%) of all patients developed pneumonia within the first 30 days after surgery. No statistically significant differences were seen between the prolonged group and control group in terms of pneumonia after 7 (p = 0.169) or 30 days (p = 0.133), detected bacterial species (all p > 0.291) and 30-day mortality (5.8 vs 10.6%, p = 0.274). Conclusion: A preemptive 5-day postoperative course of moxifloxacin does not reduce the incidence of pulmonary infection and does not improve mortality after thoracoabdominal esophagectomy. | ||
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