Vaccination titres pre- and post-transplant in paediatric renal transplant recipients and the impact of immunosuppressive therapy
Background: Avoidance of vaccine-preventable infections in paediatric renal allograft recipients is of utmost importance. However, the development and maintenance of protective vaccination titres may be impaired in this patient population owing to their need for immunosuppressive medication. Methods...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 January 2018
|
| In: |
Pediatric nephrology
Year: 2018, Jahrgang: 33, Heft: 5, Pages: 897-910 |
| ISSN: | 1432-198X |
| DOI: | 10.1007/s00467-017-3868-0 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00467-017-3868-0
|
| Verfasserangaben: | Britta Höcker, Martin Aguilar, Paul Schnitzler, Lars Pape, Martin Bald, Jens König, Stephen D. Marks, Gurkan Genc, Anja Büscher, Markus J. Kemper, Heiko Billing, Martin Pohl, Luca Dello Strologo, Nicholas J.A. Webb, Susanne Rieger, Annette Mankertz, Kai Krupka, Thomas Bruckner, Alexander Fichtner, Burkhard Tönshoff |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1691818429 | ||
| 003 | DE-627 | ||
| 005 | 20230426073022.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200306s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00467-017-3868-0 |2 doi | |
| 035 | |a (DE-627)1691818429 | ||
| 035 | |a (DE-599)KXP1691818429 | ||
| 035 | |a (OCoLC)1341309589 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Höcker, Britta |d 1974- |e VerfasserIn |0 (DE-588)122785673 |0 (DE-627)706042816 |0 (DE-576)293419795 |4 aut | |
| 245 | 1 | 0 | |a Vaccination titres pre- and post-transplant in paediatric renal transplant recipients and the impact of immunosuppressive therapy |c Britta Höcker, Martin Aguilar, Paul Schnitzler, Lars Pape, Martin Bald, Jens König, Stephen D. Marks, Gurkan Genc, Anja Büscher, Markus J. Kemper, Heiko Billing, Martin Pohl, Luca Dello Strologo, Nicholas J.A. Webb, Susanne Rieger, Annette Mankertz, Kai Krupka, Thomas Bruckner, Alexander Fichtner, Burkhard Tönshoff |
| 264 | 1 | |c 10 January 2018 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.03.2020 | ||
| 520 | |a Background: Avoidance of vaccine-preventable infections in paediatric renal allograft recipients is of utmost importance. However, the development and maintenance of protective vaccination titres may be impaired in this patient population owing to their need for immunosuppressive medication. Methods: In the framework of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN), we therefore performed a multi-centre, multi-national study and analysed vaccination titres pre- and post-transplant in 155 patients with serial titre measurements in comparison with published data in healthy children. Results: The percentage of patients with positive vaccination titres before renal transplantation (RTx) was low, especially for diphtheria (38.5%, control 75%) and pertussis (21.3%, control 96.3%). As few as 58.1% of patients had a hepatitis B antibody (HBsAb) titre >100 IU/L before RTx. 38.1% of patients showed a vaccination titre loss post-transplant. Patients with an HBsAb titre between 10 and 100 IU/L before RTx experienced a significantly (p < 0.05) more frequent hepatitis B vaccination titre loss post-transplant than patients with an HBsAb titre >100 IU/L. The revaccination rate post-transplant was low and revaccination failed to induce positive titres in a considerable number of patients (27.3 to 83.3%). Treatment with rituximab was associated with a significantly increased risk of a vaccination titre loss post-transplant (odds ratio 4.26, p = 0.033). Conclusions: These data show a low percentage of patients with positive vaccination titres pre-transplant, a low revaccination rate post-transplant with limited antibody response, and a high rate of vaccination titre losses. | ||
| 700 | 1 | |a Schnitzler, Paul |d 1959- |e VerfasserIn |0 (DE-588)1022905643 |0 (DE-627)717329798 |0 (DE-576)366155695 |4 aut | |
| 700 | 1 | |a Rieger, Susanne |e VerfasserIn |0 (DE-588)1069693707 |0 (DE-627)1041307039 |0 (DE-576)429413440 |4 aut | |
| 700 | 1 | |a Krupka, Kai |e VerfasserIn |0 (DE-588)1121311490 |0 (DE-627)874233461 |0 (DE-576)48080737X |4 aut | |
| 700 | 1 | |a Bruckner, Thomas |d 1956- |e VerfasserIn |0 (DE-588)136046215 |0 (DE-627)574429298 |0 (DE-576)300798768 |4 aut | |
| 700 | 1 | |a Fichtner, Alexander |e VerfasserIn |0 (DE-588)1070019860 |0 (DE-627)823188094 |0 (DE-576)429697740 |4 aut | |
| 700 | 1 | |a Tönshoff, Burkhard |e VerfasserIn |0 (DE-588)1032445823 |0 (DE-627)738463493 |0 (DE-576)173494196 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pediatric nephrology |d Berlin : Springer, 1987 |g 33(2018), 5, Seite 897-910 |h Online-Ressource |w (DE-627)254638872 |w (DE-600)1463004-7 |w (DE-576)074531689 |x 1432-198X |7 nnas |a Vaccination titres pre- and post-transplant in paediatric renal transplant recipients and the impact of immunosuppressive therapy |
| 773 | 1 | 8 | |g volume:33 |g year:2018 |g number:5 |g pages:897-910 |g extent:14 |a Vaccination titres pre- and post-transplant in paediatric renal transplant recipients and the impact of immunosuppressive therapy |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00467-017-3868-0 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200306 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1032445823 |a Tönshoff, Burkhard |m 1032445823:Tönshoff, Burkhard |d 910000 |d 910500 |e 910000PT1032445823 |e 910500PT1032445823 |k 0/910000/ |k 1/910000/910500/ |p 20 |y j | ||
| 998 | |g 1070019860 |a Fichtner, Alexander |m 1070019860:Fichtner, Alexander |d 910000 |d 910500 |e 910000PF1070019860 |e 910500PF1070019860 |k 0/910000/ |k 1/910000/910500/ |p 19 | ||
| 998 | |g 136046215 |a Bruckner, Thomas |m 136046215:Bruckner, Thomas |d 910000 |d 999701 |e 910000PB136046215 |e 999701PB136046215 |k 0/910000/ |k 1/910000/999701/ |p 18 | ||
| 998 | |g 1121311490 |a Krupka, Kai |m 1121311490:Krupka, Kai |d 910000 |d 910500 |e 910000PK1121311490 |e 910500PK1121311490 |k 0/910000/ |k 1/910000/910500/ |p 17 | ||
| 998 | |g 1069693707 |a Rieger, Susanne |m 1069693707:Rieger, Susanne |d 910000 |d 910500 |e 910000PR1069693707 |e 910500PR1069693707 |k 0/910000/ |k 1/910000/910500/ |p 15 | ||
| 998 | |g 1022905643 |a Schnitzler, Paul |m 1022905643:Schnitzler, Paul |d 910000 |d 911700 |e 910000PS1022905643 |e 911700PS1022905643 |k 0/910000/ |k 1/910000/911700/ |p 3 | ||
| 998 | |g 122785673 |a Höcker, Britta |m 122785673:Höcker, Britta |d 910000 |d 910500 |e 910000PH122785673 |e 910500PH122785673 |k 0/910000/ |k 1/910000/910500/ |p 1 |x j | ||
| 999 | |a KXP-PPN1691818429 |e 3604782759 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Vaccination titres pre- and post-transplant in paediatric renal transplant recipients and the impact of immunosuppressive therapy","title_sort":"Vaccination titres pre- and post-transplant in paediatric renal transplant recipients and the impact of immunosuppressive therapy"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"14 S."}],"id":{"eki":["1691818429"],"doi":["10.1007/s00467-017-3868-0"]},"relHost":[{"disp":"Vaccination titres pre- and post-transplant in paediatric renal transplant recipients and the impact of immunosuppressive therapyPediatric nephrology","type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"year":"2018","volume":"33","issue":"5","pages":"897-910","extent":"14","text":"33(2018), 5, Seite 897-910"},"language":["eng"],"note":["Gesehen am 06.12.05"],"pubHistory":["1.1987 -"],"id":{"zdb":["1463004-7"],"issn":["1432-198X"],"eki":["254638872"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Pediatric nephrology","subtitle":"journal of the International Pediatric Nephrology Association","title":"Pediatric nephrology"}],"origin":[{"dateIssuedDisp":"1987-","publisher":"Springer ; Springer","publisherPlace":"Berlin ; Heidelberg ; Berlin ; Heidelberg ; New York, NY","dateIssuedKey":"1987"}],"recId":"254638872"}],"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"10 January 2018"}],"name":{"displayForm":["Britta Höcker, Martin Aguilar, Paul Schnitzler, Lars Pape, Martin Bald, Jens König, Stephen D. Marks, Gurkan Genc, Anja Büscher, Markus J. Kemper, Heiko Billing, Martin Pohl, Luca Dello Strologo, Nicholas J.A. Webb, Susanne Rieger, Annette Mankertz, Kai Krupka, Thomas Bruckner, Alexander Fichtner, Burkhard Tönshoff"]},"language":["eng"],"recId":"1691818429","person":[{"display":"Höcker, Britta","given":"Britta","role":"aut","family":"Höcker"},{"role":"aut","family":"Schnitzler","display":"Schnitzler, Paul","given":"Paul"},{"role":"aut","family":"Rieger","given":"Susanne","display":"Rieger, Susanne"},{"given":"Kai","display":"Krupka, Kai","family":"Krupka","role":"aut"},{"given":"Thomas","display":"Bruckner, Thomas","family":"Bruckner","role":"aut"},{"role":"aut","family":"Fichtner","display":"Fichtner, Alexander","given":"Alexander"},{"family":"Tönshoff","role":"aut","display":"Tönshoff, Burkhard","given":"Burkhard"}],"note":["Gesehen am 06.03.2020"]} | ||
| SRT | |a HOECKERBRIVACCINATIO1020 | ||