Mimicking age-associated Gadd45γ dysregulation results in memory impairments in young adult mice
Age-related memory loss is observed across multiple mammalian species and preferentially affects hippocampus-dependent memory. Memory impairments are characterized by accelerated decay of spatial memories. Nevertheless, the molecular mechanisms underlying these deficits are still largely unknown. He...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 5, 2020
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| In: |
The journal of neuroscience
Year: 2020, Jahrgang: 40, Heft: 6, Pages: 1197-1210 |
| ISSN: | 1529-2401 |
| DOI: | 10.1523/JNEUROSCI.1621-19.2019 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1523/JNEUROSCI.1621-19.2019 Verlag, lizenzpflichtig, Volltext: https://www.jneurosci.org/content/40/6/1197 
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| Verfasserangaben: | David V.C. Brito, Janina Kupke, Kubra Gulmez Karaca, Benjamin Zeuch, and Ana M.M. Oliveira |
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| 520 | |a Age-related memory loss is observed across multiple mammalian species and preferentially affects hippocampus-dependent memory. Memory impairments are characterized by accelerated decay of spatial memories. Nevertheless, the molecular mechanisms underlying these deficits are still largely unknown. Here, we investigated the expression and function of the growth arrest DNA damage (Gadd45) family during aging and cognition, respectively. | ||
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