DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer
Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
03 May 2019
|
| In: |
Clinical epigenetics
Year: 2019, Jahrgang: 11, Heft: 1 |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-019-0666-5 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1186/s13148-019-0666-5
|
| Verfasserangaben: | Christoph Weigel, Jittiporn Chaisaingmongkol, Yassen Assenov, Christine Kuhmann, Volker Winkler, Irene Santi, Olga Bogatyrova, Simone Kaucher, Justo L. Bermejo, Suet Y. Leung, Tsun L. Chan, Felix Lasitschka, Manfred H. Bohrer, Alexander Marx, Roland Heyny-von Haußen, Christel Herold-Mende, Gerhard Dyckhoff, Petra Boukamp, Klaus W. Delank, Karl Hörmann, Burkhard M. Lippert, Gerald Baier, Andreas Dietz, Christopher C. Oakes, Christoph Plass, Heiko Becher, Peter Schmezer, Heribert Ramroth and Odilia Popanda |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1691878227 | ||
| 003 | DE-627 | ||
| 005 | 20220818010615.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200309s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13148-019-0666-5 |2 doi | |
| 035 | |a (DE-627)1691878227 | ||
| 035 | |a (DE-599)KXP1691878227 | ||
| 035 | |a (OCoLC)1341309538 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Weigel, Christoph |e VerfasserIn |0 (DE-588)1113307285 |0 (DE-627)867176067 |0 (DE-576)476951585 |4 aut | |
| 245 | 1 | 0 | |a DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer |c Christoph Weigel, Jittiporn Chaisaingmongkol, Yassen Assenov, Christine Kuhmann, Volker Winkler, Irene Santi, Olga Bogatyrova, Simone Kaucher, Justo L. Bermejo, Suet Y. Leung, Tsun L. Chan, Felix Lasitschka, Manfred H. Bohrer, Alexander Marx, Roland Heyny-von Haußen, Christel Herold-Mende, Gerhard Dyckhoff, Petra Boukamp, Klaus W. Delank, Karl Hörmann, Burkhard M. Lippert, Gerald Baier, Andreas Dietz, Christopher C. Oakes, Christoph Plass, Heiko Becher, Peter Schmezer, Heribert Ramroth and Odilia Popanda |
| 246 | 3 | 0 | |a two |
| 264 | 1 | |c 03 May 2019 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.03.2020 | ||
| 520 | |a Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer cases (n = 95) and in pan-cancer data from The Cancer Genome Atlas (TCGA). | ||
| 700 | 1 | |a Assenov, Yassen |e VerfasserIn |0 (DE-588)1168777356 |0 (DE-627)1032559551 |0 (DE-576)511741103 |4 aut | |
| 700 | 1 | |a Winkler, Volker |d 1978- |e VerfasserIn |0 (DE-588)136380948 |0 (DE-627)582066026 |0 (DE-576)287770257 |4 aut | |
| 700 | 1 | |a Santi, Irene |d 1977- |e VerfasserIn |0 (DE-588)1052279384 |0 (DE-627)78889515X |0 (DE-576)408031522 |4 aut | |
| 700 | 1 | |a Kaucher, Simone |d 1988- |e VerfasserIn |0 (DE-588)1155631080 |0 (DE-627)1017906513 |0 (DE-576)501794107 |4 aut | |
| 700 | 1 | |a Lorenzo Bermejo, Justo |d 1972- |e VerfasserIn |0 (DE-588)124754619 |0 (DE-627)706705572 |0 (DE-576)294483632 |4 aut | |
| 700 | 1 | |a Lasitschka, Felix |d 1979- |e VerfasserIn |0 (DE-588)140496343 |0 (DE-627)618903542 |0 (DE-576)318526077 |4 aut | |
| 700 | 1 | |a Herold-Mende, Christel |e VerfasserIn |0 (DE-588)1022936549 |0 (DE-627)717335577 |0 (DE-576)366194267 |4 aut | |
| 700 | 1 | |a Dyckhoff, Gerhard |d 1965- |e VerfasserIn |0 (DE-588)12114335X |0 (DE-627)081114346 |0 (DE-576)292556918 |4 aut | |
| 700 | 1 | |a Boukamp, Petra |e VerfasserIn |0 (DE-588)1205902406 |0 (DE-627)1691750824 |4 aut | |
| 700 | 1 | |a Plass, Christoph |d 1961- |e VerfasserIn |0 (DE-588)116753347X |0 (DE-627)1031159894 |0 (DE-576)51118106X |4 aut | |
| 700 | 1 | |a Becher, Heiko |e VerfasserIn |0 (DE-588)1027740677 |0 (DE-627)729629260 |0 (DE-576)375063439 |4 aut | |
| 700 | 1 | |a Schmezer, Peter |e VerfasserIn |0 (DE-588)1166075133 |0 (DE-627)1029983321 |0 (DE-576)510602606 |4 aut | |
| 700 | 1 | |a Ramroth, Heribert |d 1964- |e VerfasserIn |0 (DE-588)12318939X |0 (DE-627)706199669 |0 (DE-576)29359645X |4 aut | |
| 700 | 1 | |a Popanda, Odilia |e VerfasserIn |0 (DE-588)1201385857 |0 (DE-627)1684963338 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical epigenetics |d [Erscheinungsort nicht ermittelbar] : BioMed Central, 2010 |g 11(2019,1) Artikel-Nummer 67, 15 Seiten |h Online-Ressource |w (DE-627)626459028 |w (DE-600)2553921-8 |w (DE-576)325002916 |x 1868-7083 |7 nnas |a DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer |
| 773 | 1 | 8 | |g volume:11 |g year:2019 |g number:1 |g extent:15 |a DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s13148-019-0666-5 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200309 | ||
| 993 | |a Article | ||
| 998 | |g 140496343 |a Lasitschka, Felix |m 140496343:Lasitschka, Felix |d 910000 |d 912000 |e 910000PL140496343 |e 912000PL140496343 |k 0/910000/ |k 1/910000/912000/ |p 12 | ||
| 998 | |g 1201385857 |a Popanda, Odilia |m 1201385857:Popanda, Odilia |d 140000 |e 140000PP1201385857 |k 0/140000/ |p 29 |y j | ||
| 998 | |g 12318939X |a Ramroth, Heribert |m 12318939X:Ramroth, Heribert |d 50000 |e 50000PR12318939X |k 0/50000/ |p 28 | ||
| 998 | |g 1166075133 |a Schmezer, Peter |m 1166075133:Schmezer, Peter |d 140000 |e 140000PS1166075133 |k 0/140000/ |p 27 | ||
| 998 | |g 1027740677 |a Becher, Heiko |m 1027740677:Becher, Heiko |d 910000 |d 911700 |e 910000PB1027740677 |e 911700PB1027740677 |k 0/910000/ |k 1/910000/911700/ |p 26 | ||
| 998 | |g 116753347X |a Plass, Christoph |m 116753347X:Plass, Christoph |d 50000 |e 50000PP116753347X |k 0/50000/ |p 25 | ||
| 998 | |g 1205902406 |a Boukamp, Petra |m 1205902406:Boukamp, Petra |d 50000 |e 50000PB1205902406 |k 0/50000/ |p 18 | ||
| 998 | |g 12114335X |a Dyckhoff, Gerhard |m 12114335X:Dyckhoff, Gerhard |d 910000 |d 911000 |d 50000 |e 910000PD12114335X |e 911000PD12114335X |e 50000PD12114335X |k 0/910000/ |k 1/910000/911000/ |k 0/50000/ |p 17 | ||
| 998 | |g 1022936549 |a Herold-Mende, Christel |m 1022936549:Herold-Mende, Christel |d 910000 |d 911200 |e 910000PH1022936549 |e 911200PH1022936549 |k 0/910000/ |k 1/910000/911200/ |p 16 | ||
| 998 | |g 124754619 |a Lorenzo Bermejo, Justo |m 124754619:Lorenzo Bermejo, Justo |d 910000 |d 999701 |e 910000PL124754619 |e 999701PL124754619 |k 0/910000/ |k 1/910000/999701/ |p 9 | ||
| 998 | |g 1155631080 |a Kaucher, Simone |m 1155631080:Kaucher, Simone |d 910000 |d 912800 |e 910000PK1155631080 |e 912800PK1155631080 |k 0/910000/ |k 1/910000/912800/ |p 8 | ||
| 998 | |g 1052279384 |a Santi, Irene |m 1052279384:Santi, Irene |p 6 | ||
| 998 | |g 136380948 |a Winkler, Volker |m 136380948:Winkler, Volker |d 910000 |d 912800 |e 910000PW136380948 |e 912800PW136380948 |k 0/910000/ |k 1/910000/912800/ |p 5 | ||
| 998 | |g 1168777356 |a Assenov, Yassen |m 1168777356:Assenov, Yassen |d 50000 |e 50000PA1168777356 |k 0/50000/ |p 3 | ||
| 999 | |a KXP-PPN1691878227 |e 3605273351 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1691878227","note":["Gesehen am 10.03.2020"],"name":{"displayForm":["Christoph Weigel, Jittiporn Chaisaingmongkol, Yassen Assenov, Christine Kuhmann, Volker Winkler, Irene Santi, Olga Bogatyrova, Simone Kaucher, Justo L. Bermejo, Suet Y. Leung, Tsun L. Chan, Felix Lasitschka, Manfred H. Bohrer, Alexander Marx, Roland Heyny-von Haußen, Christel Herold-Mende, Gerhard Dyckhoff, Petra Boukamp, Klaus W. Delank, Karl Hörmann, Burkhard M. Lippert, Gerald Baier, Andreas Dietz, Christopher C. Oakes, Christoph Plass, Heiko Becher, Peter Schmezer, Heribert Ramroth and Odilia Popanda"]},"relHost":[{"id":{"eki":["626459028"],"issn":["1868-7083"],"zdb":["2553921-8"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"origin":[{"publisher":"BioMed Central ; Springer","dateIssuedKey":"2010","publisherPlace":"[Erscheinungsort nicht ermittelbar] ; Berlin ; Heidelberg [u.a.]","dateIssuedDisp":"2010-"}],"title":[{"title_sort":"Clinical epigenetics","title":"Clinical epigenetics"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"11","extent":"15","year":"2019","text":"11(2019,1) Artikel-Nummer 67, 15 Seiten","issue":"1"},"disp":"DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancerClinical epigenetics","pubHistory":["1.2010 -"],"note":["Gesehen am 27.05.2020"],"recId":"626459028"}],"physDesc":[{"extent":"15 S."}],"person":[{"given":"Christoph","display":"Weigel, Christoph","family":"Weigel","role":"aut"},{"display":"Assenov, Yassen","family":"Assenov","given":"Yassen","role":"aut"},{"role":"aut","family":"Winkler","display":"Winkler, Volker","given":"Volker"},{"given":"Irene","display":"Santi, Irene","family":"Santi","role":"aut"},{"given":"Simone","family":"Kaucher","display":"Kaucher, Simone","role":"aut"},{"family":"Lorenzo Bermejo","display":"Lorenzo Bermejo, Justo","given":"Justo","role":"aut"},{"role":"aut","given":"Felix","family":"Lasitschka","display":"Lasitschka, Felix"},{"role":"aut","display":"Herold-Mende, Christel","family":"Herold-Mende","given":"Christel"},{"family":"Dyckhoff","display":"Dyckhoff, Gerhard","given":"Gerhard","role":"aut"},{"role":"aut","family":"Boukamp","display":"Boukamp, Petra","given":"Petra"},{"given":"Christoph","display":"Plass, Christoph","family":"Plass","role":"aut"},{"given":"Heiko","display":"Becher, Heiko","family":"Becher","role":"aut"},{"role":"aut","display":"Schmezer, Peter","family":"Schmezer","given":"Peter"},{"given":"Heribert","display":"Ramroth, Heribert","family":"Ramroth","role":"aut"},{"given":"Odilia","family":"Popanda","display":"Popanda, Odilia","role":"aut"}],"title":[{"title_sort":"DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer","title":"DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer"}],"id":{"doi":["10.1186/s13148-019-0666-5"],"eki":["1691878227"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"03 May 2019"}]} | ||
| SRT | |a WEIGELCHRIDNAMETHYLA0320 | ||