DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer

Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer...

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Hauptverfasser: Weigel, Christoph (VerfasserIn) , Assenov, Yassen (VerfasserIn) , Winkler, Volker (VerfasserIn) , Santi, Irene (VerfasserIn) , Kaucher, Simone (VerfasserIn) , Lorenzo Bermejo, Justo (VerfasserIn) , Lasitschka, Felix (VerfasserIn) , Herold-Mende, Christel (VerfasserIn) , Dyckhoff, Gerhard (VerfasserIn) , Boukamp, Petra (VerfasserIn) , Plass, Christoph (VerfasserIn) , Becher, Heiko (VerfasserIn) , Schmezer, Peter (VerfasserIn) , Ramroth, Heribert (VerfasserIn) , Popanda, Odilia (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 03 May 2019
In: Clinical epigenetics
Year: 2019, Jahrgang: 11, Heft: 1
ISSN:1868-7083
DOI:10.1186/s13148-019-0666-5
Online-Zugang:Verlag, Volltext: https://doi.org/10.1186/s13148-019-0666-5
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Verfasserangaben:Christoph Weigel, Jittiporn Chaisaingmongkol, Yassen Assenov, Christine Kuhmann, Volker Winkler, Irene Santi, Olga Bogatyrova, Simone Kaucher, Justo L. Bermejo, Suet Y. Leung, Tsun L. Chan, Felix Lasitschka, Manfred H. Bohrer, Alexander Marx, Roland Heyny-von Haußen, Christel Herold-Mende, Gerhard Dyckhoff, Petra Boukamp, Klaus W. Delank, Karl Hörmann, Burkhard M. Lippert, Gerald Baier, Andreas Dietz, Christopher C. Oakes, Christoph Plass, Heiko Becher, Peter Schmezer, Heribert Ramroth and Odilia Popanda
Beschreibung
Zusammenfassung:Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer cases (n = 95) and in pan-cancer data from The Cancer Genome Atlas (TCGA).
Beschreibung:Gesehen am 10.03.2020
Beschreibung:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-019-0666-5