Physiological and unappreciated roles of CaMKII in the heart
In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation-contraction and also excitation-transcription coupling. Its activity can be regulated in response to changes in intracellular calcium content as well as after several post-translational modifications. Some of the ef...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 June 2018
|
| In: |
Basic research in cardiology
Year: 2018, Volume: 113, Issue: 4 |
| ISSN: | 1435-1803 |
| DOI: | 10.1007/s00395-018-0688-8 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00395-018-0688-8
|
| Author Notes: | Jan Beckendorf, Maarten M.G. van den Hoogenhof, Johannes Backs |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1691913820 | ||
| 003 | DE-627 | ||
| 005 | 20220818010810.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200309s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00395-018-0688-8 |2 doi | |
| 035 | |a (DE-627)1691913820 | ||
| 035 | |a (DE-599)KXP1691913820 | ||
| 035 | |a (OCoLC)1341309835 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Beckendorf, Jan |d 1981- |e VerfasserIn |0 (DE-588)1063822297 |0 (DE-627)812634608 |0 (DE-576)423257757 |4 aut | |
| 245 | 1 | 0 | |a Physiological and unappreciated roles of CaMKII in the heart |c Jan Beckendorf, Maarten M.G. van den Hoogenhof, Johannes Backs |
| 264 | 1 | |c 15 June 2018 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 09.03.2020 | ||
| 520 | |a In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation-contraction and also excitation-transcription coupling. Its activity can be regulated in response to changes in intracellular calcium content as well as after several post-translational modifications. Some of the effects mediated by CaMKII may be considered adaptive, while effects of sustained CaMKII activity may turn into the opposite and are detrimental to cardiac integrity and function. As such, CaMKII has long been noted as a promising target for pharmacological inhibition, but the ubiquitous nature of CaMKII has made it difficult to target CaMKII specifically where it is detrimental. In this review, we provide a brief overview of the physiological and pathophysiological properties of CaMKII signaling, but we focus on the physiological and adaptive functions of CaMKII. Furthermore, special consideration is given to the emerging role of CaMKII as a mediator of inflammatory processes in the heart. | ||
| 700 | 1 | |a Hoogenhof, Maarten van den |e VerfasserIn |0 (DE-588)1206127848 |0 (DE-627)1691914649 |4 aut | |
| 700 | 1 | |a Backs, Johannes |d 1971- |e VerfasserIn |0 (DE-588)123819040 |0 (DE-627)706437462 |0 (DE-576)293892946 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Basic research in cardiology |d [Darmstadt u.a.] : Steinkopff, 1937 |g 113(2018,4) Artikel-Nummer 29, 12 Seiten |h Online-Ressource |w (DE-627)253390265 |w (DE-600)1458470-0 |w (DE-576)072283386 |x 1435-1803 |7 nnas |a Physiological and unappreciated roles of CaMKII in the heart |
| 773 | 1 | 8 | |g volume:113 |g year:2018 |g number:4 |g extent:12 |a Physiological and unappreciated roles of CaMKII in the heart |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00395-018-0688-8 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200309 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 123819040 |a Backs, Johannes |m 123819040:Backs, Johannes |d 910000 |d 910100 |e 910000PB123819040 |e 910100PB123819040 |k 0/910000/ |k 1/910000/910100/ |p 3 |y j | ||
| 998 | |g 1206127848 |a Hoogenhof, Maarten van den |m 1206127848:Hoogenhof, Maarten van den |d 910000 |d 910100 |e 910000PH1206127848 |e 910100PH1206127848 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1063822297 |a Beckendorf, Jan |m 1063822297:Beckendorf, Jan |d 910000 |d 910100 |e 910000PB1063822297 |e 910100PB1063822297 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1691913820 |e 3605349099 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 09.03.2020"],"title":[{"title_sort":"Physiological and unappreciated roles of CaMKII in the heart","title":"Physiological and unappreciated roles of CaMKII in the heart"}],"person":[{"family":"Beckendorf","display":"Beckendorf, Jan","roleDisplay":"VerfasserIn","given":"Jan","role":"aut"},{"given":"Maarten van den","role":"aut","display":"Hoogenhof, Maarten van den","family":"Hoogenhof","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Backs","display":"Backs, Johannes","given":"Johannes","role":"aut"}],"recId":"1691913820","language":["eng"],"id":{"doi":["10.1007/s00395-018-0688-8"],"eki":["1691913820"]},"physDesc":[{"extent":"12 S."}],"name":{"displayForm":["Jan Beckendorf, Maarten M.G. van den Hoogenhof, Johannes Backs"]},"relHost":[{"title":[{"title_sort":"Basic research in cardiology","subtitle":"official journal of the German Cardiac Society","title":"Basic research in cardiology"}],"note":["Gesehen am 02.12.05","Fortsetzung der Druck-Ausgabe"],"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"id":{"issn":["1435-1803"],"zdb":["1458470-0"],"eki":["253390265"]},"titleAlt":[{"title":"Archiv für Kreislaufforschung"}],"recId":"253390265","corporate":[{"display":"Deutsche Gesellschaft für Kardiologie - Herz- und Kreislaufforschung","roleDisplay":"Herausgebendes Organ","role":"isb"}],"part":{"extent":"12","issue":"4","text":"113(2018,4) Artikel-Nummer 29, 12 Seiten","year":"2018","volume":"113"},"disp":"Physiological and unappreciated roles of CaMKII in the heartBasic research in cardiology","pubHistory":["1.1937 -"],"origin":[{"publisher":"Steinkopff ; Springer","dateIssuedDisp":"1937-","dateIssuedKey":"1937","publisherPlace":"[Darmstadt u.a.] ; Heidelberg"}]}],"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"15 June 2018"}]} | ||
| SRT | |a BECKENDORFPHYSIOLOGI1520 | ||