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Serum caspase-cleaved cytokeratin (M30) indicates severity of liver dysfunction and predicts liver outcome

[b]BACKGROUND[/b] - The Model for End-Stage Liver Disease (MELD) score is a well-established tool for assessing hepatic failure. The present retrospective study investigated whether serum keratin 18 (M65) and caspase-cleaved cytokeratin (M30) were associated with liver dysfunction and post-transplan...

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Main Authors: Oweira, Hani (Author) , Sadeghi, Mahmoud (Author) , Daniel, Volker (Author) , Mieth, Markus (Author) , Zidan, Ahmed (Author) , Khajeh, Elias (Author) , Ghamarnejad, Omid (Author) , Fonouni, Hamidreza (Author) , Weiss, Karl Heinz (Author) , Schmidt, Jan (Author) , Lahdou, Imad (Author) , Mehrabi, Arianeb (Author)
Format: Article (Journal)
Language:English
Published: 2018.06.08
In: Annals of transplantation
Year: 2018, Volume: 23, Pages: 393-400
ISSN:1425-9524
DOI:10.12659/AOT.908031
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.12659/AOT.908031
Verlag, lizenzpflichtig, Volltext: https://www.annalsoftransplantation.com/abstract/index/idArt/908031
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Author Notes:Hani Oweira, Mahmoud Sadeghi, Daniel Volker, Markus Mieth, Ahmed Zidan, Elias Khajeh, Omid Ghamarnejad, Hamidreza Fonouni, Karl Heinz Weiss, Jan Schmidt, Imad Lahdou, Arianeb Mehrabi
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Summary:[b]BACKGROUND[/b] - The Model for End-Stage Liver Disease (MELD) score is a well-established tool for assessing hepatic failure. The present retrospective study investigated whether serum keratin 18 (M65) and caspase-cleaved cytokeratin (M30) were associated with liver dysfunction and post-transplant graft failure. - [b]MATERIAL AND METHODS[/b] - A total of 147 patients with liver cirrhosis were categorized into 2 groups according to their baseline MELD score (group I: MELD score <20, n=87, and group II: MELD score ≥20, n=60). Serum M65 and M30 levels were measured by ELISA. - [b]RESULTS[/b] - Cirrhotic patients had significantly higher serum M65 and M30 levels than healthy controls (p<0.0001). Serum M65 was correlated with the MELD score and serum bilirubin (p≤0.007) and serum M30 was correlated with the MELD score, international normalized ratio, and serum bilirubin (p≤0.001). Group II had significantly higher serum M65 and M30 levels than group I (M65, p=0.025 and M30, p<0.001). Patients who lost the allograft during the first post-transplant year had significantly higher serum M30 levels than patients with a graft survival of >1 year (p=0.004). In the regression analysis, serum M30 was associated with the MELD score (odds ratio [OR]=2.545, p=0.005), serum bilirubin (OR=2.605, p=0.005) and 1-year graft loss (OR=3.61, p=0.006). - [b]CONCLUSIONS[/b] - Our data indicate that serum M30 levels reflect the degree of liver dysfunction and can predict 1-year graft loss.
Item Description:Gesehen am 11.03.2020
Physical Description:Online Resource
ISSN:1425-9524
DOI:10.12659/AOT.908031

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