Effects of vitamin D supplementation on plasma aldosterone and renin: a randomized placebo-controlled trial
Increasing evidence describes a possible interplay between vitamin D insufficiency with increased aldosterone. The authors sought to evaluate the effect of vitamin D supplementation on plasma aldosterone concentration (PAC) in patients with hypertension and 25-hydroxyvitamin D[25(OH)D] insufficiency...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 April 2016
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| In: |
The journal of clinical hypertension
Year: 2016, Volume: 18, Issue: 7, Pages: 608-613 |
| ISSN: | 1751-7176 |
| DOI: | 10.1111/jch.12825 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/jch.12825 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jch.12825 
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| Author Notes: | Martin R. Grübler, Martin Gaksch, Katharina Kienreich, Nicolas Verheyen, Johannes Schmid, Bríain W. J. Ó Hartaigh, Georg Richtig, Hubert Scharnagl, Andreas Meinitzer, Burkert Pieske, Astrid Fahrleitner‐Pammer, Winfried März, Andreas Tomaschitz, Stefan Pilz |
| Summary: | Increasing evidence describes a possible interplay between vitamin D insufficiency with increased aldosterone. The authors sought to evaluate the effect of vitamin D supplementation on plasma aldosterone concentration (PAC) in patients with hypertension and 25-hydroxyvitamin D[25(OH)D] insufficiency. The Styrian Vitamin D Hypertension Trial was a single-center, double-blind, placebo-controlled randomized clinical trial conducted from 2011 to 2014. Two hundred patients with arterial hypertension and 25(OH)D levels <30 ng/mL were enrolled. Study participants were randomized to receive either 2800 IU of vitamin D3 or placebo. The present investigation is a post hoc analysis using analysis of covariance adjusting for baseline differences. A total of 188 participants (mean±standard deviation age, 60.1±11.3 years; 47% women; 25(OH)D, 21.2±5.6 ng/mL) completed the trial. Mean differences between baseline and follow-up PAC in the control and intervention arm were +3.3 ng/dL and +0.9 ng/dL, respectively (P=.04). The findings indicate that vitamin D3 supplementation significantly decreases PAC in patients with arterial hypertension and 25(OH)D insufficiency. |
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| Item Description: | Gesehen am 11.03.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1751-7176 |
| DOI: | 10.1111/jch.12825 |