The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB
SAMHD1 is a human restriction factor known to prevent infection of macrophages, resting CD4+ T cells, and dendritic cells by HIV-1. To test the contribution of MxB to the ability of SAMHD1 to block HIV-1 infection, we created human THP-1 cell lines that were knocked out for expression of MxB, SAMHD1...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 March 2019
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| In: |
Virology
Year: 2019, Volume: 531, Pages: 260-268 |
| ISSN: | 1096-0341 |
| DOI: | 10.1016/j.virol.2019.03.018 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.virol.2019.03.018 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0042682219300893 
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| Author Notes: | Cindy Buffone, Juliane Kutzner, Silvana Opp, Alicia Martinez-Lopez, Anastasia Selyutina, Si Ana Coggings, Lydia R. Studdard, Lingmei Ding, Baek Kim, Paul Spearman, Torsten Schaller, Felipe Diaz-Griffero |
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