Cover Image

Requirement for YAP1 signaling in myxoid liposarcoma

Abstract Myxoid liposarcomas (MLS), malignant tumors of adipocyte origin, are driven by the FUS-DDIT3 fusion gene encoding an aberrant transcription factor. The mechanisms whereby FUS-DDIT3 mediates sarcomagenesis are incompletely understood, and strategies to selectively target MLS cells remain elu...

Full description

Saved in:
Bibliographic Details
Main Authors: Trautmann, Marcel (Author) , Cheng, Ya-Yun (Author) , Jensen, Patrizia (Author) , Hüllein, Jennifer (Author) , Słabicki, Mikołaj (Author) , Zenz, Thorsten (Author) , Scholl, Claudia (Author) , Fröhling, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 21 March 2019
In: EMBO molecular medicine
Year: 2019, Volume: 11, Issue: 5
ISSN:1757-4684
DOI:10.15252/emmm.201809889
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.15252/emmm.201809889
Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.15252/emmm.201809889
Get full text
Author Notes:Marcel Trautmann, Ya-Yun Cheng, Patrizia Jensen, Ninel Azoitei, Ines Brunner, Jennifer Hüllein, Mikolaj Slabicki, Ilka Isfort, Magdalene Cyra, Ruth Berthold, Eva Wardelmann, Sebastian Huss, Bianca Altvater, Claudia Rossig, Susanne Hafner, Thomas Simmet, Anders Ståhlberg, Pierre Åman, Thorsten Zenz, Undine Lange, Thomas Kindler, Claudia Scholl, Wolfgang Hartmann & Stefan Fröhling

MARC

LEADER 00000caa a2200000 c 4500
001 1692364421
003 DE-627
005 20240405193201.0
007 cr uuu---uuuuu
008 200312s2019 xx |||||o 00| ||eng c
024 7 |a 10.15252/emmm.201809889  |2 doi 
035 |a (DE-627)1692364421 
035 |a (DE-599)KXP1692364421 
035 |a (OCoLC)1341309992 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Trautmann, Marcel  |e VerfasserIn  |0 (DE-588)1054566585  |0 (DE-627)791615901  |0 (DE-576)410332097  |4 aut 
245 1 0 |a Requirement for YAP1 signaling in myxoid liposarcoma  |c Marcel Trautmann, Ya-Yun Cheng, Patrizia Jensen, Ninel Azoitei, Ines Brunner, Jennifer Hüllein, Mikolaj Slabicki, Ilka Isfort, Magdalene Cyra, Ruth Berthold, Eva Wardelmann, Sebastian Huss, Bianca Altvater, Claudia Rossig, Susanne Hafner, Thomas Simmet, Anders Ståhlberg, Pierre Åman, Thorsten Zenz, Undine Lange, Thomas Kindler, Claudia Scholl, Wolfgang Hartmann & Stefan Fröhling 
246 3 0 |a one 
264 1 |c 21 March 2019 
300 |a 15 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 25.06.2020 
520 |a Abstract Myxoid liposarcomas (MLS), malignant tumors of adipocyte origin, are driven by the FUS-DDIT3 fusion gene encoding an aberrant transcription factor. The mechanisms whereby FUS-DDIT3 mediates sarcomagenesis are incompletely understood, and strategies to selectively target MLS cells remain elusive. Here we show, using an unbiased functional genomic approach, that FUS-DDIT3-expressing mesenchymal stem cells and MLS cell lines are dependent on YAP1, a transcriptional co-activator and central effector of the Hippo pathway involved in tissue growth and tumorigenesis, and that increased YAP1 activity is a hallmark of human MLS. Mechanistically, FUS-DDIT3 promotes YAP1 expression, nuclear localization, and transcriptional activity and physically associates with YAP1 in the nucleus of MLS cells. Pharmacologic inhibition of YAP1 activity impairs the growth of MLS cells in vitro and in vivo. These findings identify overactive YAP1 signaling as unifying feature of MLS development that could represent a novel target for therapeutic intervention. 
650 4 |a FUS-DDIT3 
650 4 |a Hippo pathway 
650 4 |a myxoid liposarcoma 
650 4 |a verteporfin 
650 4 |a YAP1 
700 1 |a Cheng, Ya-Yun  |e VerfasserIn  |0 (DE-588)1153924668  |0 (DE-627)1015525806  |0 (DE-576)500644896  |4 aut 
700 1 |a Jensen, Patrizia  |e VerfasserIn  |0 (DE-588)1161886206  |0 (DE-627)1025404939  |0 (DE-576)507010027  |4 aut 
700 1 |a Hüllein, Jennifer  |e VerfasserIn  |0 (DE-588)1096556359  |0 (DE-627)856940941  |0 (DE-576)468079610  |4 aut 
700 1 |a Słabicki, Mikołaj  |d 1980-  |e VerfasserIn  |0 (DE-588)136811930  |0 (DE-627)694677477  |0 (DE-576)301287007  |4 aut 
700 1 |a Zenz, Thorsten  |d 1970-  |e VerfasserIn  |0 (DE-588)114963738  |0 (DE-627)577184202  |0 (DE-576)180278266  |4 aut 
700 1 |a Scholl, Claudia  |d 1971-  |e VerfasserIn  |0 (DE-588)128803533  |0 (DE-627)380643197  |0 (DE-576)187440271  |4 aut 
700 1 |a Fröhling, Stefan  |d 1969-  |e VerfasserIn  |0 (DE-588)120890046  |0 (DE-627)080950302  |0 (DE-576)188733930  |4 aut 
773 0 8 |i Enthalten in  |a European Molecular Biology Organization  |t EMBO molecular medicine  |d [London] : Nature Publishing Group UK, 2009  |g 11(2019,5) Artikel-Nummer e9889, 15 Seiten  |h Online-Ressource  |w (DE-627)594772761  |w (DE-600)2485479-7  |w (DE-576)305355961  |x 1757-4684  |7 nnas 
773 1 8 |g volume:11  |g year:2019  |g number:5  |g extent:15  |a Requirement for YAP1 signaling in myxoid liposarcoma 
856 4 0 |u https://doi.org/10.15252/emmm.201809889  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.embopress.org/doi/full/10.15252/emmm.201809889  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20200312 
993 |a Article 
994 |a 2019 
998 |g 136811930  |a Słabicki, Mikołaj  |m 136811930:Słabicki, Mikołaj  |p 7 
998 |g 128803533  |a Scholl, Claudia  |m 128803533:Scholl, Claudia  |d 50000  |e 50000PS128803533  |k 0/50000/  |p 22 
998 |g 1161886206  |a Jensen, Patrizia  |m 1161886206:Jensen, Patrizia  |d 50000  |e 50000PJ1161886206  |k 0/50000/  |p 3 
998 |g 120890046  |a Fröhling, Stefan  |m 120890046:Fröhling, Stefan  |d 50000  |e 50000PF120890046  |k 0/50000/  |p 24  |y j 
998 |g 114963738  |a Zenz, Thorsten  |m 114963738:Zenz, Thorsten  |p 19 
999 |a KXP-PPN1692364421  |e 3607081662 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"21 March 2019"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"name":{"displayForm":["Marcel Trautmann, Ya-Yun Cheng, Patrizia Jensen, Ninel Azoitei, Ines Brunner, Jennifer Hüllein, Mikolaj Slabicki, Ilka Isfort, Magdalene Cyra, Ruth Berthold, Eva Wardelmann, Sebastian Huss, Bianca Altvater, Claudia Rossig, Susanne Hafner, Thomas Simmet, Anders Ståhlberg, Pierre Åman, Thorsten Zenz, Undine Lange, Thomas Kindler, Claudia Scholl, Wolfgang Hartmann & Stefan Fröhling"]},"person":[{"roleDisplay":"VerfasserIn","family":"Trautmann","role":"aut","display":"Trautmann, Marcel","given":"Marcel"},{"roleDisplay":"VerfasserIn","family":"Cheng","given":"Ya-Yun","display":"Cheng, Ya-Yun","role":"aut"},{"given":"Patrizia","display":"Jensen, Patrizia","role":"aut","family":"Jensen","roleDisplay":"VerfasserIn"},{"family":"Hüllein","roleDisplay":"VerfasserIn","role":"aut","display":"Hüllein, Jennifer","given":"Jennifer"},{"given":"Mikołaj","role":"aut","display":"Słabicki, Mikołaj","roleDisplay":"VerfasserIn","family":"Słabicki"},{"family":"Zenz","roleDisplay":"VerfasserIn","given":"Thorsten","role":"aut","display":"Zenz, Thorsten"},{"family":"Scholl","roleDisplay":"VerfasserIn","display":"Scholl, Claudia","role":"aut","given":"Claudia"},{"given":"Stefan","display":"Fröhling, Stefan","role":"aut","family":"Fröhling","roleDisplay":"VerfasserIn"}],"physDesc":[{"extent":"15 S."}],"relHost":[{"note":["Gesehen am 5. November 2022","Fortsetzung der Druck-Ausgabe"],"disp":"European Molecular Biology OrganizationEMBO molecular medicine","id":{"eki":["594772761"],"doi":["10.1002/(ISSN)1757-4684"],"zdb":["2485479-7"],"issn":["1757-4684"]},"title":[{"title_sort":"EMBO molecular medicine","title":"EMBO molecular medicine"}],"part":{"text":"11(2019,5) Artikel-Nummer e9889, 15 Seiten","issue":"5","volume":"11","extent":"15","year":"2019"},"name":{"displayForm":["European Molecular Biology Organization (EMBO)"]},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"origin":[{"publisher":"Nature Publishing Group UK ; EMBO Press ; Wiley-VCH","dateIssuedDisp":"[2009]-","publisherPlace":"[London] ; Heidelberg ; Weinheim"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"corporate":[{"roleDisplay":"VerfasserIn","display":"European Molecular Biology Organization","role":"aut"}],"pubHistory":["Vol. 1, No. 1 (Apr 1, 2009)-"],"recId":"594772761"}],"recId":"1692364421","id":{"doi":["10.15252/emmm.201809889"],"eki":["1692364421"]},"title":[{"title_sort":"Requirement for YAP1 signaling in myxoid liposarcoma","title":"Requirement for YAP1 signaling in myxoid liposarcoma"}],"note":["Gesehen am 25.06.2020"]} 
SRT |a TRAUTMANNMREQUIREMEN2120 

Similar Items