Glioblastoma in elderly patients: solid conclusions built on shifting sand?
Management of glioblastoma in the elderly population is challenging. In the near future, more than half of patients with this tumor will be over the age of 65. Clinicians have been historically reluctant to treat such patients with the same intensity as younger patients. Due to upper age limits or p...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
|
| In: |
Neuro-Oncology
Year: 2017, Volume: 20, Issue: 2, Pages: 174-183 |
| ISSN: | 1523-5866 |
| DOI: | 10.1093/neuonc/nox133 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/neuonc/nox133 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/neuro-oncology/article/20/2/174/3978768 
|
| Author Notes: | Antje Wick, Tobias Kessler, Andrew E.H. Elia, Frank Winkler, Tracy T. Batchelor, Michael Platten, and Wolfgang Wick |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1692376799 | ||
| 003 | DE-627 | ||
| 005 | 20220818012822.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200312r20182017xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/neuonc/nox133 |2 doi | |
| 035 | |a (DE-627)1692376799 | ||
| 035 | |a (DE-599)KXP1692376799 | ||
| 035 | |a (OCoLC)1341310320 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wick, Antje |d 1972- |e VerfasserIn |0 (DE-588)122759869 |0 (DE-627)706032101 |0 (DE-576)293409609 |4 aut | |
| 245 | 1 | 0 | |a Glioblastoma in elderly patients |b solid conclusions built on shifting sand? |c Antje Wick, Tobias Kessler, Andrew E.H. Elia, Frank Winkler, Tracy T. Batchelor, Michael Platten, and Wolfgang Wick |
| 264 | 1 | |c 2018 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published: 18 July 2017 | ||
| 500 | |a Gesehen am 12.03.2020 | ||
| 520 | |a Management of glioblastoma in the elderly population is challenging. In the near future, more than half of patients with this tumor will be over the age of 65. Clinicians have been historically reluctant to treat such patients with the same intensity as younger patients. Due to upper age limits or poor accrual of elderly patients in clinical trials, randomized data for this patient population have been relatively sparse until recently. In this review, we will discuss the concept of an elderly patient population, describe evidence for molecular differences in glioblastoma of elderly versus young patients, evaluate recent first-line trials studying glioblastoma in elderly patients, and discuss best therapeutic practices including the value of molecular testing. | ||
| 534 | |c 2017 | ||
| 700 | 1 | |a Keßler, Tobias |d 1987- |e VerfasserIn |0 (DE-588)1104151693 |0 (DE-627)86164591X |0 (DE-576)470840277 |4 aut | |
| 700 | 1 | |a Winkler, Frank |d 1971- |e VerfasserIn |0 (DE-588)120794586 |0 (DE-627)704993104 |0 (DE-576)292388586 |4 aut | |
| 700 | 1 | |a Platten, Michael |d 1971- |e VerfasserIn |0 (DE-588)121627780 |0 (DE-627)081431848 |0 (DE-576)261969811 |4 aut | |
| 700 | 1 | |a Wick, Wolfgang |d 1970- |e VerfasserIn |0 (DE-588)120297736 |0 (DE-627)080586929 |0 (DE-576)186221320 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neuro-Oncology |d Oxford : Oxford Univ. Press, 1999 |g 20(2018), 2, Seite 174-183 |h Online-Ressource |w (DE-627)357167341 |w (DE-600)2094060-9 |w (DE-576)318041839 |x 1523-5866 |7 nnas |a Glioblastoma in elderly patients solid conclusions built on shifting sand? |
| 773 | 1 | 8 | |g volume:20 |g year:2018 |g number:2 |g pages:174-183 |g extent:10 |a Glioblastoma in elderly patients solid conclusions built on shifting sand? |
| 856 | 4 | 0 | |u https://doi.org/10.1093/neuonc/nox133 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/neuro-oncology/article/20/2/174/3978768 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200312 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 120297736 |a Wick, Wolfgang |m 120297736:Wick, Wolfgang |d 910000 |d 911100 |e 910000PW120297736 |e 911100PW120297736 |k 0/910000/ |k 1/910000/911100/ |p 7 |y j | ||
| 998 | |g 121627780 |a Platten, Michael |m 121627780:Platten, Michael |d 60000 |d 62700 |e 60000PP121627780 |e 62700PP121627780 |k 0/60000/ |k 1/60000/62700/ |p 6 | ||
| 998 | |g 120794586 |a Winkler, Frank |m 120794586:Winkler, Frank |d 910000 |d 911100 |e 910000PW120794586 |e 911100PW120794586 |k 0/910000/ |k 1/910000/911100/ |p 4 | ||
| 998 | |g 1104151693 |a Keßler, Tobias |m 1104151693:Keßler, Tobias |d 910000 |d 911100 |e 910000PK1104151693 |e 911100PK1104151693 |k 0/910000/ |k 1/910000/911100/ |p 2 | ||
| 998 | |g 122759869 |a Wick, Antje |m 122759869:Wick, Antje |d 910000 |d 911100 |e 910000PW122759869 |e 911100PW122759869 |k 0/910000/ |k 1/910000/911100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1692376799 |e 3607107823 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Glioblastoma in elderly patients","title":"Glioblastoma in elderly patients","subtitle":"solid conclusions built on shifting sand?"}],"language":["eng"],"recId":"1692376799","name":{"displayForm":["Antje Wick, Tobias Kessler, Andrew E.H. Elia, Frank Winkler, Tracy T. Batchelor, Michael Platten, and Wolfgang Wick"]},"person":[{"given":"Antje","family":"Wick","display":"Wick, Antje","role":"aut"},{"role":"aut","display":"Keßler, Tobias","family":"Keßler","given":"Tobias"},{"family":"Winkler","given":"Frank","role":"aut","display":"Winkler, Frank"},{"given":"Michael","family":"Platten","display":"Platten, Michael","role":"aut"},{"given":"Wolfgang","family":"Wick","display":"Wick, Wolfgang","role":"aut"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Published: 18 July 2017","Gesehen am 12.03.2020"],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["357167341"],"zdb":["2094060-9"],"issn":["1523-5866"]},"recId":"357167341","disp":"Glioblastoma in elderly patients solid conclusions built on shifting sand?Neuro-Oncology","language":["eng"],"origin":[{"publisherPlace":"Oxford ; Durham, NC","dateIssuedDisp":"1999-","dateIssuedKey":"1999","publisher":"Oxford Univ. Press ; Duke University Medical Center"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"Neuro-Oncology","subtitle":"official journal of the World Federation of Neuro-Oncology","title":"Neuro-Oncology"}],"part":{"issue":"2","text":"20(2018), 2, Seite 174-183","year":"2018","extent":"10","pages":"174-183","volume":"20"},"pubHistory":["1.1999 -"],"note":["Gesehen am 21.07.23"]}],"origin":[{"dateIssuedDisp":"2018","dateIssuedKey":"2018"}],"physDesc":[{"extent":"10 S."}],"id":{"eki":["1692376799"],"doi":["10.1093/neuonc/nox133"]}} | ||
| SRT | |a WICKANTJEKGLIOBLASTO2018 | ||