A potential new metabolite of gamma-hydroxybutyrate: sulfonated gamma-hydroxybutyric acid
Detection of gamma-hydroxybutyric acid (GHB) became crucial in many clinical and forensic settings due to its increasing use for recreational purposes and drug-facilitated sexual assault. Its narrow window of detection of about 3-12 h in urine represents a major problem. Analogous to ethyl glucuroni...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2016
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| In: |
International journal of legal medicine
Year: 2015, Jahrgang: 130, Heft: 2, Pages: 411-414 |
| ISSN: | 1437-1596 |
| DOI: | 10.1007/s00414-015-1235-x |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/s00414-015-1235-x Verlag, Volltext: https://link.springer.com/article/10.1007%2Fs00414-015-1235-x 
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| Verfasserangaben: | Stephanie Hanisch, Nicole Stachel, Gisela Skopp |
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| 245 | 1 | 2 | |a A potential new metabolite of gamma-hydroxybutyrate |b sulfonated gamma-hydroxybutyric acid |c Stephanie Hanisch, Nicole Stachel, Gisela Skopp |
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| 520 | |a Detection of gamma-hydroxybutyric acid (GHB) became crucial in many clinical and forensic settings due to its increasing use for recreational purposes and drug-facilitated sexual assault. Its narrow window of detection of about 3-12 h in urine represents a major problem. Analogous to ethyl glucuronide, the recently identified GHB-glucuronide exhibits a longer window of detection than the parent drug. It appeared reasonable that a sulfonated metabolite of GHB (GHB-SUL) will also be formed. Due to the lack of an appropriate standard, GHB was incubated with a human liver cytosolic fraction to produce GHB-SUL. Following development of a liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay to measure GHB and GHB-SUL, authentic urine samples (n = 5) were tested for GHB-SUL. These investigations revealed detectable signals of both GHB and GHB-SUL, strongly indicating that GHB is not only glucuronidated but also sulfonated. Given that sulfonated metabolites generally have longer half-life times than the corresponding free drugs, GHB-SUL may serve as a biomarker of GHB misuse along with its glucuronide. | ||
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