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Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: a map of the current evidence

Methylphenidate (MPH), the most common medication for children with Attention Deficit/Hyperactivity Disorder (ADHD) in many countries, is often prescribed for long periods of time. Any long-term psychotropic treatment in childhood raises concerns about possible adverse neurological and psychiatric o...

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Hauptverfasser: Krinzinger, Helga (Verfasst von) , Hall, Charlotte L (Verfasst von) , Groom, Madeleine J (Verfasst von) , Ansari, Mohammed T (Verfasst von) , Banaschewski, Tobias (Verfasst von) , Buitelaar, Jan K (Verfasst von) , Carucci, Sara (Verfasst von) , Coghill, David (Verfasst von) , Danckaerts, Marina (Verfasst von) , Dittmann, Ralf (Verfasst von) , Falissard, Bruno (Verfasst von) , Garas, Peter (Verfasst von) , Inglis, Sarah K (Verfasst von) , Kovshoff, Hanna (Verfasst von) , Kochhar, Puja (Verfasst von) , McCarthy, Suzanne (Verfasst von) , Nagy, Peter (Verfasst von) , Neubert, Antje (Verfasst von) , Roberts, Samantha (Verfasst von) , Sayal, Kapil (Verfasst von) , Sonuga-Barke, Edmund (Verfasst von) , Wong, Ian C K (Verfasst von) , Xia, Jun (Verfasst von) , Zuddas, Alessandro (Verfasst von) , Hollis, Chris (Verfasst von) , Konrad, Kerstin (Verfasst von) , Liddle, Elizabeth B (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 20 September 2019
In: Neuroscience & biobehavioral reviews
Year: 2019, Jahrgang: 107, Pages: 945-968
ISSN:1873-7528
DOI:10.1016/j.neubiorev.2019.09.023
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neubiorev.2019.09.023
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0149763419302350
Volltext
Verfasserangaben:Helga Krinzinger, Charlotte L Hall, Madeleine J Groom, Mohammed T Ansari, Tobias Banaschewski, Jan K Buitelaar, Sara Carucci, David Coghill, Marina Danckaerts, Ralf W Dittmann, Bruno Falissard, Peter Garas, Sarah K Inglis, Hanna Kovshoff, Puja Kochhar, Suzanne McCarthy, Peter Nagy, Antje Neubert, Samantha Roberts, Kapil Sayal, Edmund Sonuga-Barke, Ian C K Wong, Jun Xia, Alessandro Zuddas, Chris Hollis, Kerstin Konrad, Elizabeth B Liddle, the ADDUCE Consortium
Beschreibung
Zusammenfassung:Methylphenidate (MPH), the most common medication for children with Attention Deficit/Hyperactivity Disorder (ADHD) in many countries, is often prescribed for long periods of time. Any long-term psychotropic treatment in childhood raises concerns about possible adverse neurological and psychiatric outcomes. We aimed to map current evidence regarding neurological and psychiatric outcomes, adverse or beneficial, of long-term MPH (> 1year) treatment in ADHD. We coded studies using a “traffic light” system: Green: safe/favours MPH; Amber: warrants caution; Red: not safe/not well-tolerated. Un-categorisable study findings were coded as “Unclear”. Although some evidence suggests an elevated risk of psychosis and tics, case reports describe remission on discontinuation. Several studies suggest that long-term MPH may reduce depression and suicide in ADHD. Evidence suggests caution in specific groups including pre-school children, those with tics, and adolescents at risk for substance misuse. We identified a need for more studies that make use of large longitudinal databases, focus on specific neuropsychiatric outcomes, and compare outcomes from long-term MPH treatment with outcomes following shorter or no pharmacological intervention.
Beschreibung:Gesehen am 18.03.2020
Beschreibung:Online Resource
ISSN:1873-7528
DOI:10.1016/j.neubiorev.2019.09.023

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