Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: a map of the current evidence
Methylphenidate (MPH), the most common medication for children with Attention Deficit/Hyperactivity Disorder (ADHD) in many countries, is often prescribed for long periods of time. Any long-term psychotropic treatment in childhood raises concerns about possible adverse neurological and psychiatric o...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 September 2019
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| In: |
Neuroscience & biobehavioral reviews
Year: 2019, Jahrgang: 107, Pages: 945-968 |
| ISSN: | 1873-7528 |
| DOI: | 10.1016/j.neubiorev.2019.09.023 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neubiorev.2019.09.023 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0149763419302350 
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| Verfasserangaben: | Helga Krinzinger, Charlotte L Hall, Madeleine J Groom, Mohammed T Ansari, Tobias Banaschewski, Jan K Buitelaar, Sara Carucci, David Coghill, Marina Danckaerts, Ralf W Dittmann, Bruno Falissard, Peter Garas, Sarah K Inglis, Hanna Kovshoff, Puja Kochhar, Suzanne McCarthy, Peter Nagy, Antje Neubert, Samantha Roberts, Kapil Sayal, Edmund Sonuga-Barke, Ian C K Wong, Jun Xia, Alessandro Zuddas, Chris Hollis, Kerstin Konrad, Elizabeth B Liddle, the ADDUCE Consortium |
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| 245 | 1 | 0 | |a Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD |b a map of the current evidence |c Helga Krinzinger, Charlotte L Hall, Madeleine J Groom, Mohammed T Ansari, Tobias Banaschewski, Jan K Buitelaar, Sara Carucci, David Coghill, Marina Danckaerts, Ralf W Dittmann, Bruno Falissard, Peter Garas, Sarah K Inglis, Hanna Kovshoff, Puja Kochhar, Suzanne McCarthy, Peter Nagy, Antje Neubert, Samantha Roberts, Kapil Sayal, Edmund Sonuga-Barke, Ian C K Wong, Jun Xia, Alessandro Zuddas, Chris Hollis, Kerstin Konrad, Elizabeth B Liddle, the ADDUCE Consortium |
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| 520 | |a Methylphenidate (MPH), the most common medication for children with Attention Deficit/Hyperactivity Disorder (ADHD) in many countries, is often prescribed for long periods of time. Any long-term psychotropic treatment in childhood raises concerns about possible adverse neurological and psychiatric outcomes. We aimed to map current evidence regarding neurological and psychiatric outcomes, adverse or beneficial, of long-term MPH (> 1year) treatment in ADHD. We coded studies using a “traffic light” system: Green: safe/favours MPH; Amber: warrants caution; Red: not safe/not well-tolerated. Un-categorisable study findings were coded as “Unclear”. Although some evidence suggests an elevated risk of psychosis and tics, case reports describe remission on discontinuation. Several studies suggest that long-term MPH may reduce depression and suicide in ADHD. Evidence suggests caution in specific groups including pre-school children, those with tics, and adolescents at risk for substance misuse. We identified a need for more studies that make use of large longitudinal databases, focus on specific neuropsychiatric outcomes, and compare outcomes from long-term MPH treatment with outcomes following shorter or no pharmacological intervention. | ||
| 650 | 4 | |a ADHD | |
| 650 | 4 | |a Adverse neuropsychiatric events | |
| 650 | 4 | |a Anxiety | |
| 650 | 4 | |a Bipolar | |
| 650 | 4 | |a Long-term methylphenidate treatment | |
| 650 | 4 | |a Mood | |
| 650 | 4 | |a Psychosis | |
| 650 | 4 | |a Seizures | |
| 650 | 4 | |a Sleep disorders | |
| 650 | 4 | |a Substance use disorder | |
| 650 | 4 | |a Suicidal ideation | |
| 650 | 4 | |a Tics | |
| 700 | 1 | |a Hall, Charlotte L |e VerfasserIn |4 aut | |
| 700 | 1 | |a Groom, Madeleine J |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ansari, Mohammed T |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Sonuga-Barke, Edmund |d 1962- |e VerfasserIn |0 (DE-588)1227783264 |0 (DE-627)1748730479 |4 aut | |
| 700 | 1 | |a Wong, Ian C K |e VerfasserIn |4 aut | |
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