Distribution of control in the sulfur assimilation in Arabidopsis thaliana depends on environmental conditions
Sulfur assimilation is central to the survival of plants and has been studied under different environmental conditions. Multiple studies have been published trying to determine rate-limiting or controlling steps in this pathway. However, the picture remains inconclusive with at least two different e...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
25 January 2019
|
| In: |
The new phytologist
Year: 2019, Jahrgang: 222, Heft: 3, Pages: 1392-1404 |
| ISSN: | 1469-8137 |
| DOI: | 10.1111/nph.15704 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/nph.15704 Verlag, lizenzpflichtig, Volltext: https://nph.onlinelibrary.wiley.com/doi/abs/10.1111/nph.15704 
|
| Verfasserangaben: | Anna Feldman-Salit, Nadine Veith, Markus Wirtz, Rüdiger Hell and Ursula Kummer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1693117797 | ||
| 003 | DE-627 | ||
| 005 | 20220818014939.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200323s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/nph.15704 |2 doi | |
| 035 | |a (DE-627)1693117797 | ||
| 035 | |a (DE-599)KXP1693117797 | ||
| 035 | |a (OCoLC)1341310828 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Feldman-Salit, Anna |e VerfasserIn |0 (DE-588)143189956 |0 (DE-627)643883886 |0 (DE-576)335545262 |4 aut | |
| 245 | 1 | 0 | |a Distribution of control in the sulfur assimilation in Arabidopsis thaliana depends on environmental conditions |c Anna Feldman-Salit, Nadine Veith, Markus Wirtz, Rüdiger Hell and Ursula Kummer |
| 264 | 1 | |c 25 January 2019 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.03.2020 | ||
| 520 | |a Sulfur assimilation is central to the survival of plants and has been studied under different environmental conditions. Multiple studies have been published trying to determine rate-limiting or controlling steps in this pathway. However, the picture remains inconclusive with at least two different enzymes proposed to represent such rate-limiting steps. Here, we used computational modeling to gain an integrative understanding of the distribution of control in the sulfur assimilation pathway of Arabidopsis thaliana. For this purpose, we set up a new ordinary differential equation (ODE)-based, kinetic model of sulfur assimilation encompassing all biochemical reactions directly involved in this process. We fitted the model to published experimental data and produced a model ensemble to deal with parameter uncertainties. The ensemble was validated against additional published experimental data. We used the model ensemble to subsequently analyse the control pattern and robustly identified a set of processes that share the control in this pathway under standard conditions. Interestingly, the pattern of control is dynamic and not static, that is it changes with changing environmental conditions. Therefore, while adenosine-5′-phosphosulfate reductase (APR) and sulfite reductase (SiR) share control under standard laboratory conditions, APR takes over an even more dominant role under sulfur starvation conditions. | ||
| 650 | 4 | |a Arabidopsis thaliana | |
| 650 | 4 | |a flux control coefficients | |
| 650 | 4 | |a kinetic modeling | |
| 650 | 4 | |a metabolic control analysis | |
| 650 | 4 | |a primary sulfate assimilation pathway | |
| 650 | 4 | |a sulfate starvation | |
| 700 | 1 | |a Veith, Nadine |e VerfasserIn |0 (DE-588)1080528016 |0 (DE-627)84476938X |0 (DE-576)453593062 |4 aut | |
| 700 | 1 | |a Wirtz, Markus |e VerfasserIn |0 (DE-588)1023118378 |0 (DE-627)717709353 |0 (DE-576)36641979X |4 aut | |
| 700 | 1 | |a Hell, Rüdiger |e VerfasserIn |0 (DE-588)1022964933 |0 (DE-627)717340341 |0 (DE-576)166399647 |4 aut | |
| 700 | 1 | |a Kummer, Ursula |d 1967- |e VerfasserIn |0 (DE-588)115411682 |0 (DE-627)691297975 |0 (DE-576)176480897 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The new phytologist |d Oxford [u.a.] : Wiley-Blackwell, 1902 |g 222(2019), 3, Seite 1392-1404 |h Online-Ressource |w (DE-627)268132674 |w (DE-600)1472194-6 |w (DE-576)077608798 |x 1469-8137 |7 nnas |a Distribution of control in the sulfur assimilation in Arabidopsis thaliana depends on environmental conditions |
| 773 | 1 | 8 | |g volume:222 |g year:2019 |g number:3 |g pages:1392-1404 |g extent:13 |a Distribution of control in the sulfur assimilation in Arabidopsis thaliana depends on environmental conditions |
| 856 | 4 | 0 | |u https://doi.org/10.1111/nph.15704 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://nph.onlinelibrary.wiley.com/doi/abs/10.1111/nph.15704 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200323 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 115411682 |a Kummer, Ursula |m 115411682:Kummer, Ursula |d 700000 |d 721000 |e 700000PK115411682 |e 721000PK115411682 |k 0/700000/ |k 1/700000/721000/ |p 5 |y j | ||
| 998 | |g 1022964933 |a Hell, Rüdiger |m 1022964933:Hell, Rüdiger |p 4 | ||
| 998 | |g 1023118378 |a Wirtz, Markus |m 1023118378:Wirtz, Markus |d 700000 |d 721000 |e 700000PW1023118378 |e 721000PW1023118378 |k 0/700000/ |k 1/700000/721000/ |p 3 | ||
| 998 | |g 1080528016 |a Veith, Nadine |m 1080528016:Veith, Nadine |d 700000 |d 721000 |e 700000PV1080528016 |e 721000PV1080528016 |k 0/700000/ |k 1/700000/721000/ |p 2 | ||
| 998 | |g 143189956 |a Feldman-Salit, Anna |m 143189956:Feldman-Salit, Anna |p 1 |x j | ||
| 999 | |a KXP-PPN1693117797 |e 3611916595 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Feldman-Salit","role":"aut","given":"Anna","display":"Feldman-Salit, Anna"},{"display":"Veith, Nadine","family":"Veith","given":"Nadine","role":"aut"},{"family":"Wirtz","given":"Markus","role":"aut","display":"Wirtz, Markus"},{"display":"Hell, Rüdiger","given":"Rüdiger","role":"aut","family":"Hell"},{"display":"Kummer, Ursula","family":"Kummer","given":"Ursula","role":"aut"}],"title":[{"title_sort":"Distribution of control in the sulfur assimilation in Arabidopsis thaliana depends on environmental conditions","title":"Distribution of control in the sulfur assimilation in Arabidopsis thaliana depends on environmental conditions"}],"physDesc":[{"extent":"13 S."}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1693117797"],"doi":["10.1111/nph.15704"]},"origin":[{"dateIssuedDisp":"25 January 2019","dateIssuedKey":"2019"}],"name":{"displayForm":["Anna Feldman-Salit, Nadine Veith, Markus Wirtz, Rüdiger Hell and Ursula Kummer"]},"recId":"1693117797","note":["Gesehen am 26.03.2020"],"relHost":[{"disp":"Distribution of control in the sulfur assimilation in Arabidopsis thaliana depends on environmental conditionsThe new phytologist","recId":"268132674","part":{"pages":"1392-1404","volume":"222","text":"222(2019), 3, Seite 1392-1404","extent":"13","year":"2019","issue":"3"},"id":{"doi":["10.1111/(ISSN)1469-8137"],"eki":["268132674"],"zdb":["1472194-6"],"issn":["1469-8137"]},"origin":[{"publisherPlace":"Oxford [u.a.] ; Oxford ; Oxford [u.a.]","dateIssuedDisp":"1902-","publisher":"Wiley-Blackwell ; Blackwell Science ; Blackwell","dateIssuedKey":"1902"}],"language":["eng"],"pubHistory":["1.1902 -"],"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 29.02.09"],"titleAlt":[{"title":"New phytologist"}],"title":[{"title":"The new phytologist","subtitle":"international journal of plant science","title_sort":"new phytologist"}]}]} | ||
| SRT | |a FELDMANSALDISTRIBUTI2520 | ||