Sarcopenia as a comorbidity-independent predictor of survival following radical cystectomy for bladder cancer
BACKGROUND: A multicentre study was conducted to investigate the impact of sarcopenia as an independent predictor of oncological outcome after radical cystectomy for bladder cancer. - METHODS: In total, 500 patients with available digital computed tomography scans of the abdomen obtained within 90 d...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
25 February 2018
|
| In: |
Journal of cachexia, sarcopenia and muscle
Year: 2018, Jahrgang: 9, Heft: 3, Pages: 505-513 |
| ISSN: | 2190-6009 |
| DOI: | 10.1002/jcsm.12279 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/jcsm.12279
|
| Verfasserangaben: | Roman Mayr, Michael Gierth, Florian Zeman, Marieke Reiffen, Philipp Seeger, Felix Wezel, Armin Pycha, Evi Comploj, Matteo Bonatti, Manuel Ritter, Bas W.G. van Rhijn, Maximilian Burger, Christian Bolenz, Hans-Martin Fritsche & Thomas Martini |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1693175800 | ||
| 003 | DE-627 | ||
| 005 | 20240405193206.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200324s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/jcsm.12279 |2 doi | |
| 035 | |a (DE-627)1693175800 | ||
| 035 | |a (DE-599)KXP1693175800 | ||
| 035 | |a (OCoLC)1341310864 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mayr, Roman |d 1984- |e VerfasserIn |0 (DE-588)1081488387 |0 (DE-627)846200805 |0 (DE-576)454446594 |4 aut | |
| 245 | 1 | 0 | |a Sarcopenia as a comorbidity-independent predictor of survival following radical cystectomy for bladder cancer |c Roman Mayr, Michael Gierth, Florian Zeman, Marieke Reiffen, Philipp Seeger, Felix Wezel, Armin Pycha, Evi Comploj, Matteo Bonatti, Manuel Ritter, Bas W.G. van Rhijn, Maximilian Burger, Christian Bolenz, Hans-Martin Fritsche & Thomas Martini |
| 264 | 1 | |c 25 February 2018 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.03.2020 | ||
| 520 | |a BACKGROUND: A multicentre study was conducted to investigate the impact of sarcopenia as an independent predictor of oncological outcome after radical cystectomy for bladder cancer. - METHODS: In total, 500 patients with available digital computed tomography scans of the abdomen obtained within 90 days before surgery were identified. The lumbar skeletal muscle index was measured using pre-operative computed tomography. Cancer-specific survival (CSS) and overall survival (OS) were estimated using Kaplan-Meier curves. Predictors of CSS and OS were analysed by univariable and multivariable Cox regression models. - RESULTS: Based on skeletal muscle index, 189 patients (37.8%) were classified as sarcopenic. Patients with sarcopenia were older compared with their counterparts (P = 0.002), but both groups were comparable regarding to gender, comorbidity, tumor, node, metastasis (TNM) stage, and type of urinary diversion (all P > 0.05). In total, 234 (46.8%) patients died, and of these, 145 (29.0%) died because of urothelial carcinoma of the bladder. Sarcopenic patients had significantly worse 5 year OS (38.3% vs. 50.5%; P = 0.002) and 5 year CSS (49.5% vs. 62.3%; P = 0.016) rates compared with patients without sarcopenia. Moreover, sarcopenia was associated independently with both increased all-cause mortality (hazard ratio, 1.43; 95% confidence interval 1.09-1.87; P = 0.01) and increased cancer-specific mortality (hazard ratio, 1.42; 95% confidence interval, 1.00-2.02; P = 0.048). Our results are limited by the lack of prospective frailty assessment. - CONCLUSIONS: Sarcopenia has been shown to be an independent predictor for OS and CSS in a large multicentre study with patients undergoing radical cystectomy for bladder cancer. | ||
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Aged, 80 and over | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Bladder cancer | |
| 650 | 4 | |a Body Composition | |
| 650 | 4 | |a Comorbidity | |
| 650 | 4 | |a Cystectomy | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Frailty | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Kaplan-Meier Estimate | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Muscle, Skeletal | |
| 650 | 4 | |a Postoperative Period | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Proportional Hazards Models | |
| 650 | 4 | |a Sarcopenia | |
| 650 | 4 | |a Skeletal muscle mass | |
| 650 | 4 | |a Tomography, X-Ray Computed | |
| 650 | 4 | |a Urinary bladder neoplasm | |
| 650 | 4 | |a Urinary Bladder Neoplasms | |
| 700 | 1 | |a Gierth, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zeman, Florian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reiffen, Marieke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seeger, Philipp |d 1989- |e VerfasserIn |0 (DE-588)1206943211 |0 (DE-627)1693176491 |4 aut | |
| 700 | 1 | |a Wezel, Felix |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pycha, Armin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Comploj, Evi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bonatti, Matteo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ritter, Manuel |d 1979- |e VerfasserIn |0 (DE-588)1030329915 |0 (DE-627)73508436X |0 (DE-576)378128256 |4 aut | |
| 700 | 1 | |a van Rhijn, Bas W. G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Burger, Maximilian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bolenz, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fritsche, Hans-Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Martini, Thomas |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of cachexia, sarcopenia and muscle |d Hoboken, NJ : Wiley, 2010 |g 9(2018), 3, Seite 505-513 |h Online-Ressource |w (DE-627)642886121 |w (DE-600)2586864-0 |w (DE-576)335781330 |x 2190-6009 |7 nnas |a Sarcopenia as a comorbidity-independent predictor of survival following radical cystectomy for bladder cancer |
| 773 | 1 | 8 | |g volume:9 |g year:2018 |g number:3 |g pages:505-513 |g extent:9 |a Sarcopenia as a comorbidity-independent predictor of survival following radical cystectomy for bladder cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1002/jcsm.12279 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200324 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1030329915 |a Ritter, Manuel |m 1030329915:Ritter, Manuel |d 60000 |d 63100 |e 60000PR1030329915 |e 63100PR1030329915 |k 0/60000/ |k 1/60000/63100/ |p 10 | ||
| 998 | |g 1206943211 |a Seeger, Philipp |m 1206943211:Seeger, Philipp |d 60000 |d 63100 |e 60000PS1206943211 |e 63100PS1206943211 |k 0/60000/ |k 1/60000/63100/ |p 5 | ||
| 999 | |a KXP-PPN1693175800 |e 3612378279 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1693175800"],"doi":["10.1002/jcsm.12279"]},"origin":[{"dateIssuedDisp":"25 February 2018","dateIssuedKey":"2018"}],"name":{"displayForm":["Roman Mayr, Michael Gierth, Florian Zeman, Marieke Reiffen, Philipp Seeger, Felix Wezel, Armin Pycha, Evi Comploj, Matteo Bonatti, Manuel Ritter, Bas W.G. van Rhijn, Maximilian Burger, Christian Bolenz, Hans-Martin Fritsche & Thomas Martini"]},"relHost":[{"id":{"zdb":["2586864-0"],"eki":["642886121"],"issn":["2190-6009"]},"origin":[{"publisherPlace":"Hoboken, NJ ; Heidelberg","dateIssuedDisp":"2010-","publisher":"Wiley ; Springer-Medizin-Verl.","dateIssuedKey":"2010"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Journal of cachexia, sarcopenia and muscle","title_sort":"Journal of cachexia, sarcopenia and muscle"}],"recId":"642886121","language":["eng"],"note":["Gesehen am 16.05.24"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Sarcopenia as a comorbidity-independent predictor of survival following radical cystectomy for bladder cancerJournal of cachexia, sarcopenia and muscle","part":{"extent":"9","volume":"9","text":"9(2018), 3, Seite 505-513","pages":"505-513","issue":"3","year":"2018"},"pubHistory":["1.2010 -"]}],"physDesc":[{"extent":"9 S."}],"title":[{"title":"Sarcopenia as a comorbidity-independent predictor of survival following radical cystectomy for bladder cancer","title_sort":"Sarcopenia as a comorbidity-independent predictor of survival following radical cystectomy for bladder cancer"}],"person":[{"given":"Roman","family":"Mayr","role":"aut","roleDisplay":"VerfasserIn","display":"Mayr, Roman"},{"role":"aut","display":"Gierth, Michael","roleDisplay":"VerfasserIn","given":"Michael","family":"Gierth"},{"roleDisplay":"VerfasserIn","display":"Zeman, Florian","role":"aut","family":"Zeman","given":"Florian"},{"roleDisplay":"VerfasserIn","display":"Reiffen, Marieke","role":"aut","family":"Reiffen","given":"Marieke"},{"given":"Philipp","family":"Seeger","role":"aut","roleDisplay":"VerfasserIn","display":"Seeger, Philipp"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Wezel, Felix","given":"Felix","family":"Wezel"},{"display":"Pycha, Armin","roleDisplay":"VerfasserIn","role":"aut","family":"Pycha","given":"Armin"},{"role":"aut","display":"Comploj, Evi","roleDisplay":"VerfasserIn","given":"Evi","family":"Comploj"},{"roleDisplay":"VerfasserIn","display":"Bonatti, Matteo","role":"aut","family":"Bonatti","given":"Matteo"},{"role":"aut","display":"Ritter, Manuel","roleDisplay":"VerfasserIn","given":"Manuel","family":"Ritter"},{"family":"van Rhijn","given":"Bas W. G.","roleDisplay":"VerfasserIn","display":"van Rhijn, Bas W. G.","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Burger, Maximilian","given":"Maximilian","family":"Burger"},{"family":"Bolenz","given":"Christian","display":"Bolenz, Christian","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Fritsche, Hans-Martin","role":"aut","family":"Fritsche","given":"Hans-Martin"},{"given":"Thomas","family":"Martini","role":"aut","roleDisplay":"VerfasserIn","display":"Martini, Thomas"}],"language":["eng"],"recId":"1693175800","note":["Gesehen am 24.03.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a MAYRROMANGSARCOPENIA2520 | ||