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Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging

The “free radical theory of aging” suggests that reactive oxygen species (ROS) are responsible for age-related loss of cellular functions and, therefore, represent the main cause of aging. Redox regulation by thioredoxin-1 (TRX) plays a crucial role in responses to oxidative stress. We show that thi...

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Main Authors: Oberacker, Tina (Author) , Bajorat, Jörg (Author) , Ziola, Sabine (Author) , Schroeder, Anne (Author) , Röth, Daniel (Author) , Kastl, Lena (Author) , Edgar, Bruce A. (Author) , Wagner, Wolfgang (Author) , Gülow, Karsten (Author) , Krammer, Peter H. (Author)
Format: Article (Journal)
Language:English
Published: 27 June 2018
In: FEBS letters
Year: 2018, Volume: 592, Issue: 13, Pages: 2297-2307
ISSN:1873-3468
DOI:10.1002/1873-3468.13156
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/1873-3468.13156
Verlag, lizenzpflichtig, Volltext: https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.13156
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Author Notes:Tina Oberacker, Jörg Bajorat, Sabine Ziola, Anne Schroeder, Daniel Röth, Lena Kastl, Bruce A. Edgar, Wolfgang Wagner, Karsten Gülow and Peter H. Krammer

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