Anti-angiogenics: their role in the treatment of glioblastoma
Angiogenesis is a hallmark of glioblastomas, but anti-angiogenic therapies have fallen short of the initial expectations to relevantly change the clinical course of the disease. Only one agent, the anti-vascular endothelial growth factor (VEGF)-A antibody bevacizumab, has shown meaningful efficacy i...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 23, 2018
|
| In: |
Oncology research and treatment
Year: 2018, Jahrgang: 41, Heft: 4, Pages: 181-186 |
| ISSN: | 2296-5262 |
| DOI: | 10.1159/000488258 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000488258 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/488258 
|
| Verfasserangaben: | Frank Winkler, Matthias Osswald, Wolfgang Wick |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1693427788 | ||
| 003 | DE-627 | ||
| 005 | 20230427033649.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200327s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000488258 |2 doi | |
| 035 | |a (DE-627)1693427788 | ||
| 035 | |a (DE-599)KXP1693427788 | ||
| 035 | |a (OCoLC)1341311480 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Winkler, Frank |d 1971- |e VerfasserIn |0 (DE-588)120794586 |0 (DE-627)704993104 |0 (DE-576)292388586 |4 aut | |
| 245 | 1 | 0 | |a Anti-angiogenics |b their role in the treatment of glioblastoma |c Frank Winkler, Matthias Osswald, Wolfgang Wick |
| 264 | 1 | |c March 23, 2018 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.03.2020 | ||
| 520 | |a Angiogenesis is a hallmark of glioblastomas, but anti-angiogenic therapies have fallen short of the initial expectations to relevantly change the clinical course of the disease. Only one agent, the anti-vascular endothelial growth factor (VEGF)-A antibody bevacizumab, has shown meaningful efficacy in controlled clinical trials in glioblastoma, so far. In primary and recurrent glioblastoma, this efficacy is, however, limited to prolonging progression-free survival and to generating some additional palliative benefits, without affecting overall survival in the total population of glioblastoma patients. Here, we give an overview of the current status of anti-angiogenic therapy in glioblastoma, including how it is currently used in the clinic. Furthermore, we discuss avenues of biomarker research aiming to identify those glioblastoma patients with a higher likelihood of profiting from anti-VEGF-A therapies (and to identify those who will not). Together with novel anti-angiogenic treatment targets and combination regimens under development today, those might improve the current clinical benefits from this class of drugs in glioblastoma. | ||
| 700 | 1 | |a Osswald, Matthias |d 1982- |e VerfasserIn |0 (DE-588)139015620 |0 (DE-627)703181645 |0 (DE-576)309419069 |4 aut | |
| 700 | 1 | |a Wick, Wolfgang |d 1970- |e VerfasserIn |0 (DE-588)120297736 |0 (DE-627)080586929 |0 (DE-576)186221320 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Oncology research and treatment |d Basel : Karger, 2014 |g 41(2018), 4, Seite 181-186 |h Online-Ressource |w (DE-627)776629611 |w (DE-600)2749752-5 |w (DE-576)400081660 |x 2296-5262 |7 nnas |a Anti-angiogenics their role in the treatment of glioblastoma |
| 773 | 1 | 8 | |g volume:41 |g year:2018 |g number:4 |g pages:181-186 |g extent:6 |a Anti-angiogenics their role in the treatment of glioblastoma |
| 856 | 4 | 0 | |u https://doi.org/10.1159/000488258 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.karger.com/Article/FullText/488258 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200327 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 120297736 |a Wick, Wolfgang |m 120297736:Wick, Wolfgang |d 910000 |d 911100 |e 910000PW120297736 |e 911100PW120297736 |k 0/910000/ |k 1/910000/911100/ |p 3 |y j | ||
| 998 | |g 139015620 |a Osswald, Matthias |m 139015620:Osswald, Matthias |d 910000 |d 911100 |e 910000PO139015620 |e 911100PO139015620 |k 0/910000/ |k 1/910000/911100/ |p 2 | ||
| 998 | |g 120794586 |a Winkler, Frank |m 120794586:Winkler, Frank |d 910000 |d 911100 |e 910000PW120794586 |e 911100PW120794586 |k 0/910000/ |k 1/910000/911100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1693427788 |e 3614743322 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Frank Winkler, Matthias Osswald, Wolfgang Wick"]},"id":{"doi":["10.1159/000488258"],"eki":["1693427788"]},"relHost":[{"pubHistory":["37.2014 -"],"origin":[{"dateIssuedKey":"2014","publisherPlace":"Basel","dateIssuedDisp":"2014-","publisher":"Karger"}],"part":{"volume":"41","year":"2018","text":"41(2018), 4, Seite 181-186","extent":"6","issue":"4","pages":"181-186"},"title":[{"title_sort":"Oncology research and treatment","title":"Oncology research and treatment"}],"id":{"zdb":["2749752-5"],"issn":["2296-5262"],"eki":["776629611"]},"note":["Gesehen am 15.12.2023"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"recId":"776629611","physDesc":[{"extent":"Online-Ressource"}],"disp":"Anti-angiogenics their role in the treatment of glioblastomaOncology research and treatment"}],"person":[{"family":"Winkler","role":"aut","given":"Frank","display":"Winkler, Frank"},{"display":"Osswald, Matthias","family":"Osswald","role":"aut","given":"Matthias"},{"family":"Wick","role":"aut","given":"Wolfgang","display":"Wick, Wolfgang"}],"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"March 23, 2018"}],"note":["Gesehen am 27.03.2020"],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Anti-angiogenics","title_sort":"Anti-angiogenics","subtitle":"their role in the treatment of glioblastoma"}],"physDesc":[{"extent":"6 S."}],"recId":"1693427788"} | ||
| SRT | |a WINKLERFRAANTIANGIOG2320 | ||