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A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes

Trypanosomes have a trypanothione redox metabolism that provides the reducing equivalents for numerous essential processes, most being mediated by tryparedoxin (Tpx). While the biosynthesis and reduction of trypanothione are cytosolic, the molecular basis of the thiol redox homeostasis in the single...

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Main Authors: Ebersoll, Samantha (Author) , Bogacz, Marta (Author) , Günter, Lina M (Author) , Dick, Tobias P. (Author) , Krauth-Siegel, Renate (Author)
Format: Article (Journal)
Language:English
Published: 31 January 2020
In: eLife
Year: 2020, Volume: 9
ISSN:2050-084X
DOI:10.7554/eLife.53227
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.53227
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Author Notes:Samantha Ebersoll, Marta Bogacz, Lina M Günter, Tobias P Dick, R Luise Krauth-Siegel

MARC

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