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Age- and sex-dependent differences in patients with severe asthma included in the German Asthma Net cohort

Background - Severe asthma affects less than 5% of asthmatics, but is associated with high costs and increased mortality. The aim of this study was to assess age- and sex-dependent differences in this patient group. - Methods - Retrospective analysis of 1317 children and adults with severe asthma wh...

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Hauptverfasser: Milger-Kneidinger, Katrin (VerfasserIn) , Korn, Stephanie (VerfasserIn) , Buhl, Roland (VerfasserIn) , Hamelmann, Eckard (VerfasserIn) , Herth, Felix (VerfasserIn) , Gappa, Monika (VerfasserIn) , Drick, Nora (VerfasserIn) , Fuge, Jan (VerfasserIn) , Suhling, Hendrik (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 3 January 2020
In: Respiratory medicine
Year: 2020, Jahrgang: 162
ISSN:1532-3064
DOI:10.1016/j.rmed.2019.105858
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.rmed.2019.105858
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0954611119303725
Volltext
Verfasserangaben:Katrin Milger, Stephanie Korn, Roland Buhl, Eckard Hamelmann, Felix JF. Herth, Monika Gappa, Nora Drick, Jan Fuge, Hendrik Suhling

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520 |a Background - Severe asthma affects less than 5% of asthmatics, but is associated with high costs and increased mortality. The aim of this study was to assess age- and sex-dependent differences in this patient group. - Methods - Retrospective analysis of 1317 children and adults with severe asthma who are included in the German Asthma Net registry. - Results - There were more adults than children in the registry and patients’ mean age was 52. Apart from children <18 years, there were more women (57%) than men. The age of first diagnosis ranged from 0 to 76 years. 38% of patients had a positive bronchial reversibility after short acting bronchodilators. Quality of life, FEV1 and MEF 25 decreased with older age whereas treatment with oral steroids and monoclonal antibodies increased. An anti-eosinophil treatment was most frequently used in patients aged around 57 years, while an anti-IgE treatment was used in all age-groups including children. There were sex-dependent differences with lower values in men for FEV1, FVC, MEF 25 and DLCO. Yet, women were more frequently unable to work than men due to the disease. - Conclusion - In patients with severe asthma, clinical characteristics, but also treatments differed between age groups and between the sexes, reflecting different phenotypes of the disease. 
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