Metallothionein is elevated in liver and duodenum of Atp7b(−/−) mice
Different mutations in the copper transporter gene Atp7b are identified as the primary cause of Wilson’s disease. These changes result in high copper concentrations especially in the liver and brain, and consequently lead to a dysfunction of these organs. The Atp7(−/−) mouse is an established animal...
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| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
7 May 2018
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| In: |
BioMetals
Year: 2018, Volume: 31, Issue: 4, Pages: 617-625 |
| ISSN: | 1572-8773 |
| DOI: | 10.1007/s10534-018-0110-x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10534-018-0110-x
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| Author Notes: | Chengcheng Christine Zhang, Martin Volkmann, Sabine Tuma, Wolfgang Stremmel, Uta Merle |
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Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b−/− mice as a model for Wilson disease
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