PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma
PKR-like kinase (PERK) plays a significant role in inducing angiogenesis in various cancer types including glioblastoma. By proteomics analysis of the conditioned medium from a glioblastoma cell line treated with a PERK inhibitor, we showed that peptidylglycine α-amidating monooxygenase (PAM) expres...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 February 2020
|
| In: |
Oncogenesis
Year: 2020, Jahrgang: 9, Heft: 2 |
| ISSN: | 2157-9024 |
| DOI: | 10.1038/s41389-020-0201-8 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41389-020-0201-8 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41389-020-0201-8 
|
| Verfasserangaben: | Himanshu Soni, Julia Bode, Chi D. L. Nguyen, Laura Puccio, Michelle Neßling, Rosario M. Piro, Jonas Bub, Emma Phillips, Robert Ahrends, Betty A. Eipper, Björn Tews and Violaine Goidts |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1693624036 | ||
| 003 | DE-627 | ||
| 005 | 20221121130620.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200331s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41389-020-0201-8 |2 doi | |
| 035 | |a (DE-627)1693624036 | ||
| 035 | |a (DE-599)KXP1693624036 | ||
| 035 | |a (OCoLC)1341311761 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Soni, Himanshu |e VerfasserIn |0 (DE-588)119671665X |0 (DE-627)1678559253 |4 aut | |
| 245 | 1 | 0 | |a PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma |c Himanshu Soni, Julia Bode, Chi D. L. Nguyen, Laura Puccio, Michelle Neßling, Rosario M. Piro, Jonas Bub, Emma Phillips, Robert Ahrends, Betty A. Eipper, Björn Tews and Violaine Goidts |
| 246 | 3 | 3 | |a PERK-mediated expression of peptidylglycine alpha-amidating monooxygenase supports angiogenesis in glioblastoma |
| 264 | 1 | |c 13 February 2020 | |
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 31.03.2020 | ||
| 520 | |a PKR-like kinase (PERK) plays a significant role in inducing angiogenesis in various cancer types including glioblastoma. By proteomics analysis of the conditioned medium from a glioblastoma cell line treated with a PERK inhibitor, we showed that peptidylglycine α-amidating monooxygenase (PAM) expression is regulated by PERK under hypoxic conditions. Moreover, PERK activation via CCT020312 (a PERK selective activator) increased the cleavage and thus the generation of PAM cleaved cytosolic domain (PAM sfCD) that acts as a signaling molecule from the cytoplasm to the nuclei. PERK was also found to interact with PAM, suggesting a possible involvement in the generation of PAM sfCD. Knockdown of PERK or PAM reduced the formation of tubes by HUVECs in vitro. Furthermore, in vivo data highlighted the importance of PAM in the growth of glioblastoma with reduction of PAM expression in engrafted tumor significantly increasing the survival in mice. In summary, our data revealed PAM as a potential target for antiangiogenic therapy in glioblastoma. | ||
| 700 | 1 | |a Tews, Björn |d 1976- |e VerfasserIn |0 (DE-588)105866655X |0 (DE-627)797388052 |0 (DE-576)34674234X |4 aut | |
| 700 | 1 | |a Goidts, Violaine |d 1981- |e VerfasserIn |0 (DE-588)132073714 |0 (DE-627)517467585 |0 (DE-576)255439474 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Oncogenesis |d [Erscheinungsort nicht ermittelbar] : Nature Publ., 2012 |g 9(2020,2) Artikel-Nummer 18, 16 Seiten |h Online-Ressource |w (DE-627)72158022X |w (DE-600)2674437-5 |w (DE-576)369466284 |x 2157-9024 |7 nnas |a PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma |
| 773 | 1 | 8 | |g volume:9 |g year:2020 |g number:2 |g extent:16 |a PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41389-020-0201-8 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41389-020-0201-8 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200331 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 132073714 |a Rosenstiel-Goidts, Violaine |m 132073714:Rosenstiel-Goidts, Violaine |d 140000 |e 140000PR132073714 |k 0/140000/ |p 12 |y j | ||
| 998 | |g 105866655X |a Tews, Björn |m 105866655X:Tews, Björn |d 50000 |e 50000PT105866655X |k 0/50000/ |p 11 | ||
| 999 | |a KXP-PPN1693624036 |e 3616507111 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma","title":"PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma"}],"person":[{"roleDisplay":"VerfasserIn","display":"Soni, Himanshu","role":"aut","family":"Soni","given":"Himanshu"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Tews, Björn","given":"Björn","family":"Tews"},{"display":"Goidts, Violaine","roleDisplay":"VerfasserIn","role":"aut","family":"Goidts","given":"Violaine"}],"titleAlt":[{"title":"PERK-mediated expression of peptidylglycine alpha-amidating monooxygenase supports angiogenesis in glioblastoma"}],"recId":"1693624036","language":["eng"],"note":["Gesehen am 31.03.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1693624036"],"doi":["10.1038/s41389-020-0201-8"]},"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"13 February 2020"}],"name":{"displayForm":["Himanshu Soni, Julia Bode, Chi D. L. Nguyen, Laura Puccio, Michelle Neßling, Rosario M. Piro, Jonas Bub, Emma Phillips, Robert Ahrends, Betty A. Eipper, Björn Tews and Violaine Goidts"]},"relHost":[{"title":[{"title":"Oncogenesis","title_sort":"Oncogenesis"}],"pubHistory":["1.2012 -"],"part":{"volume":"9","text":"9(2020,2) Artikel-Nummer 18, 16 Seiten","extent":"16","year":"2020","issue":"2"},"disp":"PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastomaOncogenesis","note":["Gesehen am 08.11.13"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"72158022X","language":["eng"],"origin":[{"publisherPlace":"[Erscheinungsort nicht ermittelbar]","dateIssuedKey":"2012","publisher":"Nature Publ.","dateIssuedDisp":"2012-"}],"id":{"issn":["2157-9024"],"zdb":["2674437-5"],"eki":["72158022X"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"16 S."}]} | ||
| SRT | |a SONIHIMANSPERKMEDIAT1320 | ||