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Metformin does not affect clinically relevant outcomes in patients with idiopathic pulmonary fibrosis

BACKGROUND: Diabetes mellitus is a possible risk factor for the development of idiopathic pulmonary fibrosis (IPF), yet the effect of antidiabetic therapy on the course of IPF is unknown. - OBJECTIVES: This post hoc analysis assessed the effect of metformin on clinically relevant outcomes in patient...

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Hauptverfasser: Spagnolo, Paolo (Verfasst von) , Kreuter, Michael (Verfasst von) , Maher, Toby M. (Verfasst von) , Wuyts, Wim (Verfasst von) , Bonella, Francesco (Verfasst von) , Corte, Tamera J. (Verfasst von) , Kopf, Stefan (Verfasst von) , Weycker, Derek (Verfasst von) , Kirchgaessler, Klaus-Uwe (Verfasst von) , Ryerson, Christopher J. (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: October 2018
In: Respiration
Year: 2018, Jahrgang: 96, Heft: 4, Pages: 314-322
ISSN:1423-0356
DOI:10.1159/000489668
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000489668
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/489668
Volltext
Verfasserangaben:Paolo Spagnolo, Michael Kreuter, Toby M. Maher, Wim Wuyts, Francesco Bonella, Tamera J. Corte, Stefan Kopf, Derek Weycker, Klaus-Uwe Kirchgaessler, Christopher J. Ryerson
Beschreibung
Zusammenfassung:BACKGROUND: Diabetes mellitus is a possible risk factor for the development of idiopathic pulmonary fibrosis (IPF), yet the effect of antidiabetic therapy on the course of IPF is unknown. - OBJECTIVES: This post hoc analysis assessed the effect of metformin on clinically relevant outcomes in patients with IPF. - METHODS: For the primary analysis, patients randomized to placebo (n = 624) in 3 phase 3, double-blind, controlled trials of pirfenidone (CAPACITY [NCT00287716 and NCT00287729]; ASCEND [NCT01366209]) were categorized by baseline metformin use. The primary outcome was disease progression (forced vital capacity [FVC] decline ≥10%, 6-min walking distance [6MWD] decline ≥50 m, or death). Other outcomes included mortality, hospitalization, FVC decline (≥10 and ≥5%), and 6MWD decline. Outcomes were also assessed in patients with diabetes and/or hyperglycemia (impaired glucose tolerance [IGT] and diabetes population [IGT-diabetes population]) and all patients included in the 3 studies (intention-to-treat [ITT] population). - RESULTS: Overall, 71 (11.4%) patients were metformin users and 553 (88.6%) were nonmetformin users. Baseline data were similar between groups, except for a higher percentage of males (84.5 vs. 73.2%) and a history of diabetes (98.6 vs. 11.6%) in metformin users versus nonmetformin users. The unadjusted 1-year analyses demonstrated no significant differences in disease progression or other outcomes. A higher proportion of metformin users compared with nonmetformin users had a relative FVC decline of ≥5% (63.4 vs. 50.6%, p = 0.043). Results were similar for the IGT-diabetes population and for the ITT population. Multivariable analyses yielded similar results. - CONCLUSIONS: Metformin has no effect on clinically relevant outcomes in patients with IPF.
Beschreibung:Gesehen am 01.04.2020
Beschreibung:Online Resource
ISSN:1423-0356
DOI:10.1159/000489668

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