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Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer’s disease (AD) brains, is derived from sequential proteolytic processing of the Amyloid Precursor Protein (APP). However, the contribution of different cell types to Aβ deposition has not yet been examined in a...

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Main Authors: Rice, Heather (Author) , Marcassa, Gabriele (Author) , Chrysidou, Iordana (Author) , Horré, Katrien (Author) , Young-Pearse, Tracy L. (Author) , Müller, Ulrike C. (Author) , Saito, Takashi (Author) , Saido, Takaomi C. (Author) , Vassar, Robert (Author) , de Wit, Joris (Author) , De Strooper, Bart (Author)
Format: Article (Journal)
Language:English
Published: 08 January 2020
In: Molecular neurodegeneration
Year: 2020, Volume: 15, Issue: 1
ISSN:1750-1326
DOI:10.1186/s13024-019-0356-y
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13024-019-0356-y
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Author Notes:Heather C. Rice, Gabriele Marcassa, Iordana Chrysidou, Katrien Horré, Tracy L. Young-Pearse, Ulrike C. Müller, Takashi Saito, Takaomi C. Saido, Robert Vassar, Joris de Wit and Bart De Strooper

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