Genomic footprints of activated telomere maintenance mechanisms in cancer

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with di...

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Main Authors:	Sieverling, Lina Katharine (Author) , Hong, Chen (Author) , Koser, Sandra D. (Author) , Ginsbach, Philip (Author) , Kleinheinz, Kortine (Author) , Hutter, Barbara (Author) , Braun, Delia (Author) , Cortés-Ciriano, Isidro (Author) , Xi, Ruibin (Author) , Kabbe, Rolf (Author) , Park, Peter J. (Author) , Eils, Roland (Author) , Schlesner, Matthias (Author) , Brors, Benedikt (Author) , Rippe, Karsten (Author) , Jones, David T. W. (Author) , Feuerbach, Lars (Author)
Format:	Article (Journal)
Language:	English
Published:	05 February 2020
In:	Nature Communications Year: 2020, Volume: 11
ISSN:	2041-1723
DOI:	10.1038/s41467-019-13824-9
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-019-13824-9 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-019-13824-9
Author Notes:	Lina Sieverling, Chen Hong, Sandra D. Koser, Philip Ginsbach, Kortine Kleinheinz, Barbara Hutter, Delia M. Braun, Isidro Cortés-Ciriano, Ruibin Xi, Rolf Kabbe, Peter J. Park, Roland Eils, Matthias Schlesner, PCAWG-Structural Variation Working Group, Benedikt Brors, Karsten Rippe, David T. W. Jones, Lars Feuerbach & PCAWG Consortium