Estimation of the α/β ratio of non-small cell lung cancer treated with stereotactic body radiotherapy
High-dose hypofractionated radiotherapy should theoretically result in a deviation from the typical linear-quadratic shape of the cell survival curve beyond a certain threshold dose, yet no evidence for this hypothesis has so far been found in clinical data of stereotactic body radiotherapy treatmen...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2020
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| In: |
Radiotherapy and oncology
Year: 2019, Jahrgang: 142, Pages: 210-216 |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2019.07.008 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2019.07.008 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0167814019329986 
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| Verfasserangaben: | Rainer J. Klement, Jan-Jakob Sonke, Michael Allgäuer, Nicolaus Andratschke, Steffen Appold, José Belderbos, Claus Belka, Karin Dieckmann, Hans T. Eich, Michael Flentje, Inga Grills, Michael Eble, Andrew Hope, Anca L. Grosu, Sabine Semrau, Reinhart A. Sweeney, Juliane Hörner-Rieber, Maria Werner-Wasik, Rita Engenhart-Cabillic, Hong Ye, Matthias Guckenberger |
MARC
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| 245 | 1 | 0 | |a Estimation of the α/β ratio of non-small cell lung cancer treated with stereotactic body radiotherapy |c Rainer J. Klement, Jan-Jakob Sonke, Michael Allgäuer, Nicolaus Andratschke, Steffen Appold, José Belderbos, Claus Belka, Karin Dieckmann, Hans T. Eich, Michael Flentje, Inga Grills, Michael Eble, Andrew Hope, Anca L. Grosu, Sabine Semrau, Reinhart A. Sweeney, Juliane Hörner-Rieber, Maria Werner-Wasik, Rita Engenhart-Cabillic, Hong Ye, Matthias Guckenberger |
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| 520 | |a High-dose hypofractionated radiotherapy should theoretically result in a deviation from the typical linear-quadratic shape of the cell survival curve beyond a certain threshold dose, yet no evidence for this hypothesis has so far been found in clinical data of stereotactic body radiotherapy treatment (SBRT) for early-stage non-small cell lung cancer (NSCLC). A pragmatic explanation is a larger α/β ratio than the conventionally assumed 10Gy. We here attempted an estimation of the α/β ratio for NSCLC treated with SBRT using individual patient data. | ||
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| 650 | 4 | |a Linear-quadratic model | |
| 650 | 4 | |a NSCLC | |
| 650 | 4 | |a Radiobiology | |
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