Cell cycle arrest and cell death correlate with the extent of ischaemia and reperfusion injury inpatients following kidney transplantation: results of an observational pilot study
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 March 2018
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| In: |
Transplant international
Year: 2018, Jahrgang: 31, Heft: 7, Pages: 751-760 |
| ISSN: | 1432-2277 |
| DOI: | 10.1111/tri.13148 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/tri.13148 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.13148 
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| Verfasserangaben: | Felix C.F. Schmitt, Eduardo Salgado, Janina Friebe, Thomas Schmoch, Florian Uhle, Thomas Fleming, Johanna Zemva, Lars Kihm, Christian Nusshag, Christian Morath, Martin Zeier, Thomas Bruckner, Arianeb Mehrabi, Peter P. Nawroth, Markus A. Weigand, Stefan Hofer & Thorsten Brenner |
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| 245 | 1 | 0 | |a Cell cycle arrest and cell death correlate with the extent of ischaemia and reperfusion injury inpatients following kidney transplantation |b results of an observational pilot study |c Felix C.F. Schmitt, Eduardo Salgado, Janina Friebe, Thomas Schmoch, Florian Uhle, Thomas Fleming, Johanna Zemva, Lars Kihm, Christian Nusshag, Christian Morath, Martin Zeier, Thomas Bruckner, Arianeb Mehrabi, Peter P. Nawroth, Markus A. Weigand, Stefan Hofer & Thorsten Brenner |
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| 500 | |a A prolonged cold ischaemia time (CIT) is suspected to be associated with anincreased ischaemia and reperfusion injury (IRI) resulting in an increaseddamage to the graft. In total, 91 patients were evaluated for a delayed graftfunction within 7 days after kidney transplantation (48 deceased, 43 livingdonors). Blood and urine samples were collected before, immediately afterthe operation, and 1, 3, 5, 7 and 10 days later. Plasma and/or urine levels oftotal keratin 18 (total K18), caspase-cleaved keratin 18 (cc K18), the solublereceptor for advanced glycation end products (sRAGE), tissue inhibitor ofmetalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding pro-tein-7 (IGFBP7) were measured. As a result of prolonged CIT and increasedIRI, deceased donor transplantations were shown to suffer from a more dis-tinct cell cycle arrest and necrotic cell death. Plasmatic total K18 and urinaryTIMP-2 and IGFBP7 were therefore demonstrated to be of value for thedetection of a delayed graft function (DGF), as they improved the diagnosticperformance of a routinely used clinical scoring system. Plasmatic total K18and urinary TIMP-2 and IGFBP7 measurements are potentially suitable forearly identification of patients at high risk for a DGF following kidney trans-plantation from deceased or living donors | ||
| 650 | 4 | |a cell cycle arrest | |
| 650 | 4 | |a cell death | |
| 650 | 4 | |a delayed graft function | |
| 650 | 4 | |a ischaemia and reperfusion injury | |
| 650 | 4 | |a kidney transplantation | |
| 650 | 4 | |a total keratin 18 | |
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