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Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebo-controlled, randomised, double blind, multi-centre study

Traumatic brain injury is a leading cause of death and disability worldwide. The nitric oxide synthase inhibitor Ronopterin was shown to improve clinical outcome by enhancing neuroprotection in a phase IIa trial.

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Bibliographic Details
Main Authors: Tegtmeier, Frank (Author) , Unterberg, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 14 January 2020
In: Trials
Year: 2020, Volume: 21, Pages: 1-9
ISSN:1468-6694
DOI:10.1186/s13063-019-3965-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13063-019-3965-4
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Author Notes:Frank Tegtmeier, Reinhard Schinzel, Ronny Beer, Diederik Bulters, Jean-Yves LeFrant, Joan Sahuquillo, Andreas Unterberg, Peter Andrews, Antonio Belli, Javier Ibanez, Alfonso Lagares, Michael Mokry, Harald Willschke, Charlotte Flüh, Erich Schmutzhard and on behalf of the NOSTRA Investigators

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