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Quality of life following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy for vertebral metastases: Secondary Analysis of an Exploratory Phase II Randomized Trial

BACKGROUND/AIM: This was a prespecified secondary analysis of a randomized trial, which analyzed quality of life (QOL), fatigue, and emotional distress following stereotactic body radiotherapy (SBRT) versus conventional three-dimensional conformal radiotherapy (3DCRT) as part of palliative managemen...

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Main Authors: Sprave, Tetyana (Author) , Verma, Vivek (Author) , Förster, Robert (Author) , Schlampp, Ingmar (Author) , Bruckner, Thomas (Author) , Bostel, Tilman (Author) , El-Shafie, Rami (Author) , Nicolay, Nils (Author) , Debus, Jürgen (Author) , Rief, Harald (Author)
Format: Article (Journal)
Language:English
Published: August 2018
In: Anticancer research
Year: 2018, Volume: 38, Issue: 8, Pages: 4961-4968
ISSN:1791-7530
DOI:10.21873/anticanres.12814
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.12814
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Author Notes:Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Thomas Bruckner, Tilman Bostel, Rami Ateayh El Shafie, Nils Henrik Nicolay, Jürgen Debus, Harald Rief

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245 1 0 |a Quality of life following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy for vertebral metastases  |b Secondary Analysis of an Exploratory Phase II Randomized Trial  |c Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Thomas Bruckner, Tilman Bostel, Rami Ateayh El Shafie, Nils Henrik Nicolay, Jürgen Debus, Harald Rief 
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520 |a BACKGROUND/AIM: This was a prespecified secondary analysis of a randomized trial, which analyzed quality of life (QOL), fatigue, and emotional distress following stereotactic body radiotherapy (SBRT) versus conventional three-dimensional conformal radiotherapy (3DCRT) as part of palliative management of painful spinal metastases. - MATERIALS AND METHODS: Fifty-five patients were enrolled in this single-institutional randomized exploratory phase II trial (NCT02358720). Participants were randomly assigned to receive SBRT (single-fraction 24 Gy) or 3DCRT (30 Gy/10 fractions). QOL (EORTC QLQ-BM22), fatigue (EORTC QLQ FA13), and emotional distress (QSC-R10) at the end of radiotherapy, along with 3- and 6-month follow-up were assessed. - RESULTS: At all recorded time points, there were no significant QOL differences between cohorts, including painful sites, pain characteristics, functional impairment, or psychosocial aspects (p>0.05 for all). There were also no differences in all dimensions of fatigue between groups at each recorded time point (p>0.05 for all). Emotional distress was also similar at three (p=0.248) and six months (p=0.603). - CONCLUSION: Although these results demonstrate that SBRT does not cause worse QOL deteriorations compared to 3DCRT, larger randomized investigations are recommended to corroborate these findings. 
650 4 |a Affective Symptoms 
650 4 |a Breast Neoplasms 
650 4 |a Cancer Pain 
650 4 |a fatigue 
650 4 |a Fatigue 
650 4 |a Female 
650 4 |a Humans 
650 4 |a Kidney Neoplasms 
650 4 |a Lung Neoplasms 
650 4 |a Male 
650 4 |a Middle Aged 
650 4 |a Palliative Care 
650 4 |a palliative radiotherapy 
650 4 |a quality of life 
650 4 |a Quality of Life 
650 4 |a Radiosurgery 
650 4 |a Radiotherapy, Conformal 
650 4 |a Spinal Neoplasms 
650 4 |a Spine metastases 
650 4 |a stereotactic body radiation therapy 
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