Radiation-induced acute toxicities after image-guided intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for patients with spinal metastases (IRON-1 trial): first results of a randomized controlled trial = Radiogene Akuttoxizität nach bildgeführter intensitätsmodulierter Strahlentherapie versus dreidimensionaler konformaler Strahlentherapie bei Patienten mit Wirbelkörpermetastasen (IRON-1 trial)
PURPOSE: Radiation therapy (RT) provides an important treatment approach in the palliative care of vertebral metastases, but radiation-induced toxicities in patients with advanced disease and low performance status can have substantial implications for quality of life. Herein, we prospectively compa...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
05 July 2018
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| In: |
Strahlentherapie und Onkologie
Year: 2018, Jahrgang: 194, Heft: 10, Pages: 911-920 |
| ISSN: | 1439-099X |
| DOI: | 10.1007/s00066-018-1333-z |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00066-018-1333-z
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| Verfasserangaben: | Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Thomas Bruckner, Tilman Bostel, Stefan Ezechiel Welte, Eric Tonndorf-Martini, Rami El Shafie, Nils Henrik Nicolay, Jürgen Debus, Harald Rief |
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| 245 | 1 | 0 | |a Radiation-induced acute toxicities after image-guided intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for patients with spinal metastases (IRON-1 trial) |b first results of a randomized controlled trial = Radiogene Akuttoxizität nach bildgeführter intensitätsmodulierter Strahlentherapie versus dreidimensionaler konformaler Strahlentherapie bei Patienten mit Wirbelkörpermetastasen (IRON-1 trial) |c Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Thomas Bruckner, Tilman Bostel, Stefan Ezechiel Welte, Eric Tonndorf-Martini, Rami El Shafie, Nils Henrik Nicolay, Jürgen Debus, Harald Rief |
| 246 | 3 | 1 | |a Radiogene Akuttoxizität nach bildgeführter intensitätsmodulierter Strahlentherapie versus dreidimensionaler konformaler Strahlentherapie bei Patienten mit Wirbelkörpermetastasen (IRON-1 trial) |
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| 520 | |a PURPOSE: Radiation therapy (RT) provides an important treatment approach in the palliative care of vertebral metastases, but radiation-induced toxicities in patients with advanced disease and low performance status can have substantial implications for quality of life. Herein, we prospectively compared toxicity profiles of intensity-modulated radiotherapy (IMRT) vs. conventional three-dimensional conformal radiotherapy (3DCRT). - METHODS: This was a prospective randomized monocentric explorative pilot trial to compare radiation-induced toxicity between IMRT and 3DCRT for patients with spinal metastases. A total of 60 patients were randomized between November 2016 and May 2017. In both cohorts, RT was delivered in 10 fractions of 3Gy each. The primary endpoint was radiation-induced toxicity at 3 months. - RESULTS: Median follow-up was 4.3 months. Two patients suffered from grade 3 acute toxicities in the IMRT arm, along with 1 patient in the 3DCRT group. At 12 weeks after treatment (t2), 1 patient reported grade 3 toxicity in the IMRT arm vs. 4 patients in the 3DCRT group. No grade 4 or 5 adverse events occurred in either group. In the IMRT arm, the most common side effects by the end of irradiation (t1) were grade 1-2 xerostomia and nausea in 8 patients each (29.6%), and dyspnea in 7 patients (25.9%). In the 3DCRT group, the most frequent adverse events (t1) were similar: grade 1-2 xerostomia (n= 10, 35.7%), esophagitis (n= 10, 35.8%), nausea (n= 10, 35.8%), and dyspnea (n= 5, 17.9%). - CONCLUSION: This is the first randomized trial to evaluate radiation-induced toxicities after IMRT versus 3DCRT in patients with vertebral metastases. This trial demonstrated an additional improvement for IMRT in terms of acute side effects, although longer follow-up is required to further ascertain other endpoints. | ||
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Cohort Studies | |
| 650 | 4 | |a Dose Fractionation, Radiation | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Follow-Up Studies | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Intensity-modulated radiotherapy | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Palliative Care | |
| 650 | 4 | |a Palliative radiotherapy | |
| 650 | 4 | |a Pilot Projects | |
| 650 | 4 | |a Prospective Studies | |
| 650 | 4 | |a Radiation Injuries | |
| 650 | 4 | |a Radiotherapy, Conformal | |
| 650 | 4 | |a Radiotherapy, Image-Guided | |
| 650 | 4 | |a Radiotherapy, Intensity-Modulated | |
| 650 | 4 | |a Side effects | |
| 650 | 4 | |a Spinal bone metastases | |
| 650 | 4 | |a Spinal Neoplasms | |
| 650 | 4 | |a Toxicity | |
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