Pharmacokinetics of fentanyl and its derivatives in children: a comprehensive review
Fentanyl and its derivatives sufentanil, alfentanil, and remifentanil are potent opioids. A comprehensive review of the use of fentanyl and its derivatives in the pediatric population was performed using the National Library of Medicine PubMed. Studies were included if they contained original pharma...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2018
|
| In: |
Clinical pharmacokinetics
Year: 2017, Jahrgang: 57, Heft: 2, Pages: 125-149 |
| ISSN: | 1179-1926 |
| DOI: | 10.1007/s40262-017-0569-6 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s40262-017-0569-6
|
| Verfasserangaben: | Victoria C. Ziesenitz, Janelle D. Vaughns, Gilbert Koch, Gerd Mikus, Johannes N. van den Anker |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1693845164 | ||
| 003 | DE-627 | ||
| 005 | 20240405193211.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200402r20182017xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s40262-017-0569-6 |2 doi | |
| 035 | |a (DE-627)1693845164 | ||
| 035 | |a (DE-599)KXP1693845164 | ||
| 035 | |a (OCoLC)1341313569 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ziesenitz, Victoria C. |d 1985- |e VerfasserIn |0 (DE-588)1036795640 |0 (DE-627)751696099 |0 (DE-576)386865132 |4 aut | |
| 245 | 1 | 0 | |a Pharmacokinetics of fentanyl and its derivatives in children |b a comprehensive review |c Victoria C. Ziesenitz, Janelle D. Vaughns, Gilbert Koch, Gerd Mikus, Johannes N. van den Anker |
| 264 | 1 | |c 2018 | |
| 300 | |a 25 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 7 July 2017 | ||
| 500 | |a Gesehen am 02.04.2020 | ||
| 520 | |a Fentanyl and its derivatives sufentanil, alfentanil, and remifentanil are potent opioids. A comprehensive review of the use of fentanyl and its derivatives in the pediatric population was performed using the National Library of Medicine PubMed. Studies were included if they contained original pharmacokinetic parameters or models using established routes of administration in patients younger than 18 years of age. Of 372 retrieved articles, 44 eligible pharmacokinetic studies contained data of 821 patients younger than 18 years of age, including more than 46 preterm infants, 64 full-term neonates, 115 infants/toddlers, 188 children, and 28 adolescents. Underlying diagnoses included congenital heart and pulmonary disease and abdominal disorders. Routes of drug administration were intravenous, epidural, oral-transmucosal, intranasal, and transdermal. Despite extensive use in daily clinical practice, few studies have been performed. Preterm and term infants have lower clearance and protein binding. Pharmacokinetics was not altered by chronic renal or hepatic disease. Analyses of the pooled individual patients’ data revealed that clearance maturation relating to body weight could be best described by the Hill function for sufentanil (R2 = 0.71, Bmax 876 mL/min, K50 16.3 kg) and alfentanil (R2 = 0.70, Bmax (fixed) 420 mL/min, K50 28 kg). The allometric exponent for estimation of clearance of sufentanil was 0.99 and 0.75 for alfentanil clearance. Maturation of remifentanil clearance was described by linear regression to bodyweight (R2 = 0.69). The allometric exponent for estimation of remifentanil clearance was 0.76. For fentanyl, linear regression showed only a weak correlation between clearance and bodyweight in preterm and term neonates (R2 = 0.22) owing to a lack of data in older age groups. A large heterogeneity regarding study design, clinical setting, drug administration, laboratory assays, and pharmacokinetic estimation was observed between studies introducing bias into the analyses performed in this review. A limitation of this review is that pharmacokinetic data, based on different modes of administration, dosing schemes, and parameter estimation methods, were combined. | ||
| 534 | |c 2017 | ||
| 700 | 1 | |a Mikus, Gerd |e VerfasserIn |0 (DE-588)110903137 |0 (DE-627)691097941 |0 (DE-576)336988710 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical pharmacokinetics |d Berlin [u.a.] : Springer, 1976 |g 57(2018), 2, Seite 125-149 |h Online-Ressource |w (DE-627)327644974 |w (DE-600)2043781-X |w (DE-576)10337339X |x 1179-1926 |7 nnas |a Pharmacokinetics of fentanyl and its derivatives in children a comprehensive review |
| 773 | 1 | 8 | |g volume:57 |g year:2018 |g number:2 |g pages:125-149 |g extent:25 |a Pharmacokinetics of fentanyl and its derivatives in children a comprehensive review |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s40262-017-0569-6 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200402 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 110903137 |a Mikus, Gerd |m 110903137:Mikus, Gerd |d 910000 |d 910100 |e 910000PM110903137 |e 910100PM110903137 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1036795640 |a Ziesenitz, Victoria C. |m 1036795640:Ziesenitz, Victoria C. |d 910000 |d 910500 |e 910000PZ1036795640 |e 910500PZ1036795640 |k 0/910000/ |k 1/910000/910500/ |p 1 |x j | ||
| 999 | |a KXP-PPN1693845164 |e 3617693962 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"recId":"1693845164","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Published online: 7 July 2017","Gesehen am 02.04.2020"],"title":[{"title":"Pharmacokinetics of fentanyl and its derivatives in children","subtitle":"a comprehensive review","title_sort":"Pharmacokinetics of fentanyl and its derivatives in children"}],"person":[{"family":"Ziesenitz","given":"Victoria C.","display":"Ziesenitz, Victoria C.","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Mikus, Gerd","role":"aut","family":"Mikus","given":"Gerd"}],"relHost":[{"title":[{"title_sort":"Clinical pharmacokinetics","title":"Clinical pharmacokinetics"}],"pubHistory":["1.1976 -"],"part":{"year":"2018","issue":"2","pages":"125-149","text":"57(2018), 2, Seite 125-149","volume":"57","extent":"25"},"disp":"Pharmacokinetics of fentanyl and its derivatives in children a comprehensive reviewClinical pharmacokinetics","note":["Gesehen am 06.03.13","Ungezählte Beil.: Suppl"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"327644974","language":["eng"],"origin":[{"publisher":"Springer ; Adis Intern.","dateIssuedKey":"1976","dateIssuedDisp":"1976-","publisherPlace":"Berlin [u.a.] ; Auckland"}],"id":{"issn":["1179-1926"],"eki":["327644974"],"zdb":["2043781-X"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"25 S."}],"id":{"doi":["10.1007/s40262-017-0569-6"],"eki":["1693845164"]},"origin":[{"dateIssuedDisp":"2018","dateIssuedKey":"2018"}],"name":{"displayForm":["Victoria C. Ziesenitz, Janelle D. Vaughns, Gilbert Koch, Gerd Mikus, Johannes N. van den Anker"]}} | ||
| SRT | |a ZIESENITZVPHARMACOKI2018 | ||