Translation acrobatics: how cancer cells exploit alternate modes of translational initiation
Recent work has brought to light many different mechanisms of translation initiation that function in cells in parallel to canonical cap‐dependent initiation. This has important implications for cancer. Canonical cap‐dependent translation initiation is inhibited by many stresses such as hypoxia, nut...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 September 2018
|
| In: |
EMBO reports
Year: 2018, Jahrgang: 19, Heft: 10 |
| ISSN: | 1469-3178 |
| DOI: | 10.15252/embr.201845947 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.15252/embr.201845947 Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172470/ 
|
| Verfasserangaben: | Ashwin Sriram, Jonathan Bohlen & Aurelio A Teleman |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1694042561 | ||
| 003 | DE-627 | ||
| 005 | 20220818031253.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200403s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.15252/embr.201845947 |2 doi | |
| 035 | |a (DE-627)1694042561 | ||
| 035 | |a (DE-599)KXP1694042561 | ||
| 035 | |a (OCoLC)1341313728 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Sriram, Ashwin |e VerfasserIn |0 (DE-588)1207568511 |0 (DE-627)1694045153 |4 aut | |
| 245 | 1 | 0 | |a Translation acrobatics |b how cancer cells exploit alternate modes of translational initiation |c Ashwin Sriram, Jonathan Bohlen & Aurelio A Teleman |
| 264 | 1 | |c 17 September 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.04.2020 | ||
| 520 | |a Recent work has brought to light many different mechanisms of translation initiation that function in cells in parallel to canonical cap‐dependent initiation. This has important implications for cancer. Canonical cap‐dependent translation initiation is inhibited by many stresses such as hypoxia, nutrient limitation, proteotoxic stress, or genotoxic stress. Since cancer cells are often exposed to these stresses, they rely on alternate modes of translation initiation for protein synthesis and cell growth. Cancer mutations are now being identified in components of the translation machinery and in cis‐regulatory elements of mRNAs, which both control translation of cancer‐relevant genes. In this review, we provide an overview on the various modes of non‐canonical translation initiation, such as leaky scanning, translation re‐initiation, ribosome shunting, IRES‐dependent translation, and m6A‐dependent translation, and then discuss the influence of stress on these different modes of translation. Finally, we present examples of how these modes of translation are dysregulated in cancer cells, allowing them to grow, to proliferate, and to survive, thereby highlighting the importance of translational control in cancer. | ||
| 700 | 1 | |a Bohlen, Jonathan |d 1991- |e VerfasserIn |0 (DE-588)1181118379 |0 (DE-627)1662644019 |4 aut | |
| 700 | 1 | |a Teleman, Aurelio A. |d 1976- |e VerfasserIn |0 (DE-588)1155118294 |0 (DE-627)1016370121 |0 (DE-576)501431861 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a European Molecular Biology Organization |t EMBO reports |d [London] : Nature Publishing Group UK, 2000 |g 19(2018,10) Artikel-Nummer e45947, 19 Seiten |h Online-Ressource |w (DE-627)320645622 |w (DE-600)2025376-X |w (DE-576)095092153 |x 1469-3178 |7 nnas |
| 773 | 1 | 8 | |g volume:19 |g year:2018 |g number:10 |a Translation acrobatics how cancer cells exploit alternate modes of translational initiation |
| 856 | 4 | 0 | |u https://doi.org/10.15252/embr.201845947 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172470/ |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200403 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1155118294 |a Teleman, Aurelio A. |m 1155118294:Teleman, Aurelio A. |d 140000 |e 140000PT1155118294 |k 0/140000/ |p 3 |y j | ||
| 998 | |g 1181118379 |a Bohlen, Jonathan |m 1181118379:Bohlen, Jonathan |d 140000 |e 140000PB1181118379 |k 0/140000/ |p 2 | ||
| 998 | |g 1207568511 |a Sriram, Ashwin |m 1207568511:Sriram, Ashwin |d 140000 |e 140000PS1207568511 |k 0/140000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1694042561 |e 3618465130 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"recId":"320645622","pubHistory":["1.2000 -"],"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["European Molecular Biology Organization"]},"id":{"eki":["320645622"],"issn":["1469-3178"],"zdb":["2025376-X"],"doi":["10.1002/(ISSN)1469-3178"]},"disp":"European Molecular Biology OrganizationEMBO reports","corporate":[{"display":"European Molecular Biology Organization","role":"aut"}],"language":["eng"],"part":{"volume":"19","text":"19(2018,10) Artikel-Nummer e45947, 19 Seiten","issue":"10","year":"2018"},"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 11.03.25"],"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisher":"Nature Publishing Group UK ; EMBO Press ; Oxford Univ. Press ; Nature Publishing Group ; Wiley","publisherPlace":"[London] ; Heidelberg ; Oxford [u.a.] ; London [u.a.] ; Hoboken, NJ [u.a.]","dateIssuedDisp":"[2000]-"}],"title":[{"title_sort":"EMBO reports","title":"EMBO reports"}]}],"id":{"doi":["10.15252/embr.201845947"],"eki":["1694042561"]},"recId":"1694042561","name":{"displayForm":["Ashwin Sriram, Jonathan Bohlen & Aurelio A Teleman"]},"language":["eng"],"note":["Gesehen am 03.04.2020"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"17 September 2018","dateIssuedKey":"2018"}],"title":[{"title_sort":"Translation acrobatics","subtitle":"how cancer cells exploit alternate modes of translational initiation","title":"Translation acrobatics"}],"person":[{"family":"Sriram","display":"Sriram, Ashwin","given":"Ashwin","role":"aut"},{"given":"Jonathan","role":"aut","family":"Bohlen","display":"Bohlen, Jonathan"},{"role":"aut","given":"Aurelio A.","family":"Teleman","display":"Teleman, Aurelio A."}]} | ||
| SRT | |a SRIRAMASHWTRANSLATIO1720 | ||