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cIMPACT-NOW: a practical summary of diagnostic points from Round 1 updates

cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to provide a forum to evaluate and recommend proposed changes to future CNS tumor classifications. From 2016 to 2019 (Round 1), cIMPACT published four updates. Update 1 clarified the use o...

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Main Authors: Louis, David N. (Author) , Ellison, David W. (Author) , Brat, Daniel J. (Author) , Aldape, Kenneth (Author) , Capper, David (Author) , Hawkins, Cynthia (Author) , Paulus, Werner (Author) , Perry, Arie (Author) , Reifenberger, Guido (Author) , Figarella‐Branger, Dominique (Author) , Deimling, Andreas von (Author) , Wesseling, Pieter (Author)
Format: Article (Journal)
Language:English
Published: 30 April 2019
In: Brain pathology
Year: 2019, Volume: 29, Issue: 4, Pages: 469-472
ISSN:1750-3639
DOI:10.1111/bpa.12732
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/bpa.12732
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bpa.12732
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Author Notes:David N. Louis; David W. Ellison; Daniel J. Brat; Kenneth Aldape; David Capper; Cynthia Hawkins; Werner Paulus; Arie Perry; Guido Reifenberger; Dominique Figarella‐Branger; Andreas von Deimling; Pieter Wesseling
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Summary:cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to provide a forum to evaluate and recommend proposed changes to future CNS tumor classifications. From 2016 to 2019 (Round 1), cIMPACT published four updates. Update 1 clarified the use of the term NOS (Not Otherwise Specified) and proposed use of the additional term NEC (Not Elsewhere Classified). Update 2 issued clarifications regarding two diagnoses: Diffuse Midline Glioma, H3 K27M-mutant and Diffuse Astrocytoma/Anaplastic Astrocytoma, IDH-mutant. Update 3 proposed molecular criteria that could be used in the setting of an IDH-wildtype diffuse or anaplastic astrocytic glioma without histological features of glioblastoma to infer that the tumor would behave similarly to a grade IV glioblastoma. Update 4 suggested that, in children and young adults, subtypes of IDH-wildtype/H3-wildtype diffuse gliomas may have distinct clinical features in the setting of a BRAFV600E mutation, FGFR1 alteration, other MAPK pathway alteration, or a MYB or MYBL1 rearrangement. The practical diagnostic relevance of these cIMPACT proposals is highlighted in this summary.
Item Description:Gesehen am 03.04.2020
Physical Description:Online Resource
ISSN:1750-3639
DOI:10.1111/bpa.12732

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