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Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis

The sequestration of misfolded proteins into large assemblies by sequestrases is now considered as the third pillar in protein quality control besides chaperones and proteases. Here the authors characterise the functions of the sequestrases Hsp42 and Btn2 in the proteostasis network of S. cerevisiae...

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Main Authors: Ho, Chi-Ting (Author) , Jawed, Areeb (Author) , Zahn, Regina (Author) , Bukau, Bernd (Author) , Mogk, Axel (Author)
Format: Article (Journal)
Language:English
Published: 24 October 2019
In: Nature Communications
Year: 2019, Volume: 10
ISSN:2041-1723
DOI:10.1038/s41467-019-12868-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-019-12868-1
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-019-12868-1
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Author Notes:Chi-ting Ho, Tomas Grousl, Oren Shatz, Areeb Jawed, Carmen Ruger-Herreros, Marije Semmelink, Regina Zahn, Karsten Richter, Bernd Bukau & Axel Mogk

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