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Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signalling

Transferrin receptor 2 (Trf2) is known to regulate iron homeostasis through its action in the liver. Here the authors report a previously unrecognised role of Trf2 in regulating bone homeostasis mediated by modulation of BMP signalling specifically on osteoblasts.

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Bibliographische Detailangaben
Hauptverfasser: Rauner, Martina (VerfasserIn) , Altamura, Sandro (VerfasserIn) , Colucci, Silvia (VerfasserIn) , Muckenthaler, Martina (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 07 January 2019
In: Nature metabolism
Year: 2019, Jahrgang: 1, Heft: 1, Pages: 111-124
ISSN:2522-5812
DOI:10.1038/s42255-018-0005-8
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s42255-018-0005-8
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s42255-018-0005-8
Volltext
Verfasserangaben:Martina Rauner, Ulrike Baschant, Antonella Roetto, Rosa Maria Pellegrino, Sandra Rother, Juliane Salbach-Hirsch, Heike Weidner, Vera Hintze, Graeme Campbell, Andreas Petzold, Regis Lemaitre, Ian Henry, Teresita Bellido, Igor Theurl, Sandro Altamura, Silvia Colucci, Martina U. Muckenthaler, Georg Schett, Davide S.K. Komla-Ebri, J.H. Duncan Bassett, Graham R. Williams, Uwe Platzbecker & Lorenz C. Hofbauer

MARC

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