Endothelial Notch signaling controls insulin transport in muscle
The role of the endothelium is not just limited to acting as an inert barrier for facilitating blood transport. Endothelial cells (ECs), through expression of a repertoire of angiocrine molecules, regulate metabolic demands in an organ-specific manner. Insulin flux across the endothelium to muscle c...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 March 2020
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| In: |
EMBO molecular medicine
Year: 2020, Volume: 12, Issue: 4 |
| ISSN: | 1757-4684 |
| DOI: | 10.15252/emmm.201809271 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.15252/emmm.201809271 Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.15252/emmm.201809271 
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| Author Notes: | Sana S Hasan, Markus Jabs, Jacqueline Taylor, Lena Wiedmann, Thomas Leibing, Viola Nordström, Giuseppina Federico, Leticia P Roma, Christopher Carlein, Gretchen Wolff, Bilgen Ekim-Üstünel, Maik Brune, Iris Moll, Fabian Tetzlaff, Hermann-Josef Gröne, Thomas Fleming, Cyrill Géraud, Stephan Herzig, Peter P Nawroth & Andreas Fischer |
MARC
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| 520 | |a The role of the endothelium is not just limited to acting as an inert barrier for facilitating blood transport. Endothelial cells (ECs), through expression of a repertoire of angiocrine molecules, regulate metabolic demands in an organ-specific manner. Insulin flux across the endothelium to muscle cells is a rate-limiting process influencing insulin-mediated lowering of blood glucose. Here, we demonstrate that Notch signaling in ECs regulates insulin transport to muscle. | ||
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