Cover Image

Changes in glutathione redox potential are linked to Aβ42-induced neurotoxicity

Glutathione is the major low-molecular weight thiol of eukaryotic cells. It is central to one of the two major NADPH-dependent reducing systems and is likely to play a role in combating oxidative stress, a process suggested to play a key role in Alzheimer’s disease (AD). However, the nature and rele...

Full description

Saved in:
Bibliographic Details
Main Authors: Stapper, Zeenna A. (Author) , Jahn, Thomas R. (Author)
Format: Article (Journal)
Language:English
Published: 14 August 2018
In: Cell reports
Year: 2018, Volume: 24, Issue: 7, Pages: 1696-1703
ISSN:2211-1247
DOI:10.1016/j.celrep.2018.07.052
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.celrep.2018.07.052
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S2211124718311550
Get full text
Author Notes:Zeenna A. Stapper, Thomas R. Jahn

MARC

LEADER 00000caa a2200000 c 4500
001 1694280721
003 DE-627
005 20240405193213.0
007 cr uuu---uuuuu
008 200408s2018 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.celrep.2018.07.052  |2 doi 
035 |a (DE-627)1694280721 
035 |a (DE-599)KXP1694280721 
035 |a (OCoLC)1341314398 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Stapper, Zeenna A.  |e VerfasserIn  |0 (DE-588)1161014268  |0 (DE-627)1024423050  |0 (DE-576)506306941  |4 aut 
245 1 0 |a Changes in glutathione redox potential are linked to Aβ42-induced neurotoxicity  |c Zeenna A. Stapper, Thomas R. Jahn 
246 3 3 |a Changes in glutathione redox potential are linked to A[beta]42-induced neurotoxicity 
264 1 |c 14 August 2018 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 08.04.2020 
500 |a Im Titel ist "42" in Aβ42-induced tiefgestellt 
520 |a Glutathione is the major low-molecular weight thiol of eukaryotic cells. It is central to one of the two major NADPH-dependent reducing systems and is likely to play a role in combating oxidative stress, a process suggested to play a key role in Alzheimer’s disease (AD). However, the nature and relevance of redox changes in the onset and progression of AD are still uncertain. Here, we combine genetically encoded redox sensors with our Drosophila models of amyloid-beta (Aβ) aggregation. We find that changes in glutathione redox potential (EGSH) closely correlate with disease onset and progression. We observe this redox imbalance specifically in neurons, but not in glia cells. EGSH changes and Aβ42 deposition are also accompanied by increased JNK stress signaling. Furthermore, pharmacologic and genetic manipulation of glutathione synthesis modulates Aβ42-mediated neurotoxicity, suggesting a causal relationship between disturbed glutathione redox homeostasis and early AD pathology. 
650 4 |a Alzheimer’s disease 
650 4 |a amyloid-beta 
650 4 |a glutathione redox balance 
650 4 |a models 
650 4 |a redox sensors 
700 1 |a Jahn, Thomas R.  |e VerfasserIn  |0 (DE-588)116368953X  |0 (DE-627)1028067844  |0 (DE-576)508167027  |4 aut 
773 0 8 |i Enthalten in  |t Cell reports  |d Maryland Heights, MO : Cell Press, 2012  |g 24(2018), 7, Seite 1696-1703  |h Online-Ressource  |w (DE-627)684964562  |w (DE-600)2649101-1  |w (DE-576)358411572  |x 2211-1247  |7 nnas  |a Changes in glutathione redox potential are linked to Aβ42-induced neurotoxicity 
773 1 8 |g volume:24  |g year:2018  |g number:7  |g pages:1696-1703  |g extent:8  |a Changes in glutathione redox potential are linked to Aβ42-induced neurotoxicity 
856 4 0 |u https://doi.org/10.1016/j.celrep.2018.07.052  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S2211124718311550  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20200408 
993 |a Article 
994 |a 2018 
998 |g 116368953X  |a Jahn, Thomas R.  |m 116368953X:Jahn, Thomas R.  |d 50000  |e 50000PJ116368953X  |k 0/50000/ 
998 |g 1161014268  |a Stapper, Zeenna A.  |m 1161014268:Stapper, Zeenna A.  |d 140000  |e 140000PS1161014268  |k 0/140000/  |p 1  |x j 
999 |a KXP-PPN1694280721  |e 3620639019 
BIB |a Y 
SER |a journal 
JSO |a {"title":[{"title":"Changes in glutathione redox potential are linked to Aβ42-induced neurotoxicity","title_sort":"Changes in glutathione redox potential are linked to Aβ42-induced neurotoxicity"}],"person":[{"given":"Zeenna A.","family":"Stapper","role":"aut","roleDisplay":"VerfasserIn","display":"Stapper, Zeenna A."},{"roleDisplay":"VerfasserIn","display":"Jahn, Thomas R.","role":"aut","family":"Jahn","given":"Thomas R."}],"titleAlt":[{"title":"Changes in glutathione redox potential are linked to A[beta]42-induced neurotoxicity"}],"language":["eng"],"recId":"1694280721","type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 08.04.2020","Im Titel ist \"42\" in Aβ42-induced tiefgestellt"],"id":{"doi":["10.1016/j.celrep.2018.07.052"],"eki":["1694280721"]},"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"14 August 2018"}],"name":{"displayForm":["Zeenna A. Stapper, Thomas R. Jahn"]},"relHost":[{"recId":"684964562","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Changes in glutathione redox potential are linked to Aβ42-induced neurotoxicityCell reports","physDesc":[{"extent":"Online-Ressource"}],"part":{"extent":"8","text":"24(2018), 7, Seite 1696-1703","volume":"24","issue":"7","pages":"1696-1703","year":"2018"},"pubHistory":["1.2012 -"],"id":{"zdb":["2649101-1"],"eki":["684964562"],"issn":["2211-1247"]},"title":[{"title_sort":"Cell reports","title":"Cell reports"}],"origin":[{"dateIssuedDisp":"2012-","dateIssuedKey":"2012","publisher":"Cell Press ; Elsevier","publisherPlace":"Maryland Heights, MO ; [New York, NY]"}]}],"physDesc":[{"extent":"8 S."}]} 
SRT |a STAPPERZEECHANGESING1420 

Similar Items